Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in middle ear morphogenesis and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including chordate embryonic development; negative regulation of Wnt signaling pathway; and signal transduction involved in regulation of gene expression. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; forebrain; genitourinary system; limb; and sensory organ. Orthologous to human GSC (goosecoid homeobox).