Grin2c
Gene Detail

Symbol Name ID

Grin2c glutamate receptor, ionotropic, NMDA2C (epsilon 3) MGI:95822

Synonyms

GluRepsilon3, NMDAR2C, NR2C

Feature Type

protein coding gene

Genetic Map

Chromosome 11

80.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:115249169-115265429 bp, - strand From VEGA annotation of GRCm38   16261 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:647  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Grin2c

Human homologs

Human Homolog		GRIN2C, glutamate receptor, ionotropic, N-methyl D-aspartate 2C
NCBI Gene ID		2905
neXtProt AC		NX_Q14957
Human Synonyms		GluN2C, NMDAR2C, NR2C
Human Chr (Location)		17q25; chr17:72838168-72856007 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(11)
 

Homozygotes for targeted null mutations exhibit deficits in motor coordination and reduced granule cell responses to N-methy-D-aspartate in brain slices.

 

Gene Ontology (GO) classifications

All GO classifications: (51 annotations)

Process	cation transport, directional locomotion, ...
Component	cell junction, cytoplasm, ...
Function	cation channel activity, extracellular-glutamate-gated ion channel activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (102)    Tissues (79)    Images (9)
Theiler Stages: 23, 26, 28

Assay Type	Results
RNA in situ	48
RT-PCR	54

cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(7) cDNA(19) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000003665 (Evidence)
Ensembl Gene Model	ENSMUSG00000020734 (Evidence)
Entrez Gene	14813 (Evidence)
UniGene	39090
DFCI	TC1584496, TC1731708
DoTS	DT.60103499, DT.97383943
NIA Mouse Gene Index	U033612
Consensus CDS Project	CCDS25624.1
International Mouse Knockout Project Status	Grin2c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003665	VEGA Gene Model | MGI Sequence Detail	16261	C57BL/6J
transcript	OTTMUST00000007921	VEGA | MGI Sequence Detail	4279	Not Applicable
polypeptide	OTTMUSP00000003841	VEGA | MGI Sequence Detail	1239	Not Applicable

All sequences(38) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(75 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR018884	Glutamate [NMDA] receptor, epsilon subunit, C-terminal
InterPro	IPR019594	Glutamate receptor, L-glutamate/glycine-binding
InterPro	IPR001320	Ionotropic glutamate receptor
InterPro	IPR001508	NMDA receptor
Protein Ontology	PR:000008248	glutamate [NMDA] receptor subunit epsilon-3

References

(Earliest) J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
(Latest) J:189692 Zhang Y, et al., NR2C in the thalamic reticular nucleus; effects of the NR2C knockout. PLoS One. 2012;7(7):e41908
All references(88)

Other accession IDs

MGD-MRK-10260