About   Help   FAQ
Grin2c
Gene Detail
Symbol

Name
ID
Grin2c
glutamate receptor, ionotropic, NMDA2C (epsilon 3)
MGI:95822
Synonyms
GluRepsilon3, NMDAR2C, NR2C
Feature Type
protein coding gene
Genetic Map
Chromosome 11
80.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:115249169-115265429 bp, - strand
From VEGA annotation of GRCm38

  16261 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:647  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GRIN2C
Gene Tree: Grin2c

Human
homologs
GRIN2C, glutamate receptor, ionotropic, N-methyl D-aspartate 2C
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2905
neXtProt AC: NX_Q14957

Human Synonyms: GluN2C, NMDAR2C, NR2C

Human Chr (Location): 17q25.1; chr17:74842021-74861514 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit deficits in motor coordination and reduced granule cell responses to N-methy-D-aspartate in brain slices.
 
Interactions
Grin2c interacts with 53 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process cation transmembrane transport, cation transport, ...
Component cell junction, dendrite, ...
Function cation channel activity, extracellular-glutamate-gated ion channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (102)    Tissues (80)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 48
RT-PCR 54
cDNA source data(19)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase grin2c    NEW 
Molecular
reagents
All nucleic(29) Genomic(7) cDNA(19) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000003665 (Evidence)
Ensembl Gene Model ENSMUSG00000020734 (Evidence)
Entrez Gene 14813 (Evidence)
UniGene 39090
DFCI TC1584496, TC1731708
DoTS DT.60103499, DT.97383943
NIA Mouse Gene Index U033612
Consensus CDS Project CCDS25624.1
International Mouse Phenotyping Consortium Status Grin2c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003665 VEGA Gene Model | MGI Sequence Detail 16261 C57BL/6J ±  kb
transcript OTTMUST00000007921 VEGA | MGI Sequence Detail 4279 Not Applicable 
polypeptide OTTMUSP00000003841 VEGA | MGI Sequence Detail 1239 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(20) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008248 glutamate receptor ionotropic, NMDA 2C
References
(Earliest) J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
(Latest) J:201986 Sun M, et al., Crybb2 coding for betaB2-crystallin affects sensorimotor gating and hippocampal function. Mamm Genome. 2013 Oct;24(9-10):333-48
All references(87)
Other
accession IDs
MGD-MRK-10260

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory