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Grin2c
Gene Detail
 Symbol
Name
ID
Grin2c
glutamate receptor, ionotropic, NMDA2C (epsilon 3)
MGI:95822
Synonyms GluRepsilon3, NMDAR2C, NR2C
Feature Type protein coding gene
Genetic Map
Chromosome 11
80.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:115249169-115265429 bp, - strand
From VEGA annotation of GRCm38

  16261 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:647  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Grin2c

Human
homologs
Human Homolog GRIN2C, glutamate receptor, ionotropic, N-methyl D-aspartate 2C
NCBI Gene ID 2905
neXtProt AC  NX_Q14957
Human Synonyms  GluN2C, NMDAR2C, NR2C
Human Chr (Location)  17q25.1; chr17:74842023-74860843 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit deficits in motor coordination and reduced granule cell responses to N-methy-D-aspartate in brain slices.
 
Interactions
Grin2c interacts with 53 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process cation transmembrane transport, cation transport, ...
Component cell junction, dendrite, ...
Function cation channel activity, extracellular-glutamate-gated ion channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (102)    Tissues (80)    Images (9)
Theiler Stages: 23, 26, 27, 28
Assay TypeResults
RNA in situ 48
RT-PCR 54
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(7) cDNA(19) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000003665 (Evidence)
Ensembl Gene ModelENSMUSG00000020734 (Evidence)
Entrez Gene14813 (Evidence)
UniGene39090
DFCITC1584496, TC1731708
DoTSDT.60103499, DT.97383943
NIA Mouse Gene IndexU033612
Consensus CDS ProjectCCDS25624.1
International Mouse Knockout Project StatusGrin2c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003665 VEGA Gene Model | MGI Sequence Detail 16261 C57BL/6J ±  kb
transcript OTTMUST00000007921 VEGA | MGI Sequence Detail 4279 Not Applicable 
polypeptide OTTMUSP00000003841 VEGA | MGI Sequence Detail 1239 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(19) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008248 glutamate receptor ionotropic, NMDA 2C
References (Earliest) J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
(Latest) J:201986 Sun M, et al., Crybb2 coding for betaB2-crystallin affects sensorimotor gating and hippocampal function. Mamm Genome. 2013 Oct;24(9-10):333-48
All references(89)
Other
accession IDs
MGD-MRK-10260

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory