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Grik2 Gene Detail
Summary
  • Symbol
    Grik2
  • Name
    glutamate receptor, ionotropic, kainate 2 (beta 2)
  • Synonyms
    Glur6, Glur-6, Glurbeta2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95815
    NCBI Gene: 14806
  • Gene Overview
    MyGene.info: GRIK2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:49099460-49788766 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      689307 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 24.87 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GRIK2, glutamate ionotropic receptor kainate type subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRIK2, glutamate ionotropic receptor kainate type subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EAA4, GLR6, GluK2, GLUK6, GLUR6, MRT6
  • Links
    NCBI Gene ID: 2898
    neXtProt AC: NX_Q13002
    UniProt: Q13002

  • Chr Location
    6q16.3; chr6:101393708-102070083 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human GRIK2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit hippocampal neurons with reduced sensitivity to kainate and reduced susceptibility to the seizure-inducing effects of kainate administration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016255 VEGA Gene Model | MGI Sequence Detail 689307 C57BL/6J ±  kb
    transcript OTTMUST00000038976 VEGA | MGI Sequence Detail 4800 Not Applicable  
    polypeptide OTTMUSP00000017420 VEGA | MGI Sequence Detail 908 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      3122 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000008241 glutamate receptor ionotropic, kainate 2
    • InterPro Domains
      IPR001320 Ionotropic glutamate receptor
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 2
      cDNA 13
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10145, MGD-MRK-10152, MGD-MRK-10253, MGI:2143816
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 18
      Gene Ontology 34
      Phenotypes 44
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:262943 Grosenbaugh DK, et al., The Role of Kainate Receptors in the Pathophysiology of Hypoxia-Induced Seizures in the Neonatal Mouse. Sci Rep. 2018 May 4;8(1):7035

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory