Grik2 MGI Mouse Gene Detail - MGI:95815 - glutamate receptor, ionotropic, kainate 2 (beta 2)

Symbol

Grik2
Name

glutamate receptor, ionotropic, kainate 2 (beta 2)
Synonyms

C130030K03Rik, Glur-6, Glur6, Glurbeta2

Feature Type

protein coding gene
IDs

MGI:95815
NCBI Gene: 14806
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr10:48970929-49664862 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 24.87 cM
Mapping Data

4 experiments

SNPs within 2kb

20057 from dbSNP Build 142
Strain Annotations

19
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95815	protein coding gene	Chr10:48969776-49666523 (-)
129S1/SvImJ	ENSMUSG00200006704	protein coding gene	Chr10:45863872-46552682 (-)
A/J	ENSMUSG00195002873	protein coding gene	Chr10:46141618-46830465 (-)
AKR/J	ENSMUSG00220005709	protein coding gene	Chr10:45822840-46512632 (-)
BALB/cJ	ENSMUSG00180011771	protein coding gene	Chr10:46246255-46958534 (-)
C3H/HeJ	ENSMUSG00175009743	protein coding gene	Chr10:46012824-46701583 (-)
C57BL/6NJ	ENSMUSG00215002000	protein coding gene	Chr10:45768305-46457125 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015301	protein coding gene	Chr10:44296487-44973031 (-)
CAST/EiJ	ENSTCUG00005008173	protein coding gene	Chr10:46019087-46700510 (-)
CBA/J	ENSMUSG00210007935	protein coding gene	Chr10:45915916-46604712 (-)
DBA/2J	ENSMUSG00185003114	protein coding gene	Chr10:46072084-46760904 (-)
FVB/NJ	ENSMUSG00205004885	protein coding gene	Chr10:45976943-46665575 (-)
JF1/MsJ	ENSUMUG00000017417	protein coding gene	Chr10:45765355-46461932 (-)
LP/J	ENSMUSG00230005154	protein coding gene	Chr10:47873832-48562578 (-)
NOD/ShiLtJ	ENSMUSG00190005444	protein coding gene	Chr10:46226845-46915604 (-)
NZO/HlLtJ	ENSMUSG00225022467	protein coding gene	Chr10:52154773-52843510 (-)
PWK/PhJ	ENSLUMG00010004520	protein coding gene	Chr10:45876684-46577942 (-)
SPRET/EiJ	ENSMSPG00010012701	protein coding gene	Chr10:47023479-47732476 (-)
WSB/EiJ	ENSIUOG00005014549	protein coding gene	Chr10:45832165-46526252 (-)

Human Ortholog

GRIK2, glutamate ionotropic receptor kainate type subunit 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRIK2, glutamate ionotropic receptor kainate type subunit 2
Synonyms

EAA4, GLR6, GluK2, GLUK6, GLUR6, MRT6, NEDLAS
Links

HGNC:4580

NCBI Gene ID: 2898

UniProt: Q13002
Chr Location

6q16.3; chr6:100962701-102081622 (+) GRCh38

MGI Vertebrate Homology

Grik2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GRIK2
Gene Tree

Grik2

Diseases

2 with human GRIK2 associations

				Human Disease	Mouse Models
				autosomal recessive intellectual developmental disorder 6 IDs autosomal recessive intellectual developmental disorder 6 DOID:0081182 OMIM:611092
				Huntington's disease IDs Huntington's disease DOID:12858 ICD10CM:G10 ICD9CM_2006:333.4 ICD9CM:333.4 KEGG:05016 MESH:D006816 NCI:C82342 OMIM:143100 UMLS_CUI:C0020179

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
64 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

1
Endonuclease-mediated

8
Gene trapped

1
Radiation induced

1
Targeted

9
Genomic Mutations

2 involving Grik2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

66 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit hippocampal neurons with reduced sensitivity to kainate and reduced susceptibility to the seizure-inducing effects of kainate administration.

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All GO Annotations

158
GO References

44

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

893
Tissues

118
cDNA Data

14
Literature Summary

23

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN grik2

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All Sequences

100
RefSeq

34
UniProt

8
CCDS

CCDS23830.1, CCDS48554.1

Ensembl

ENSMUSG00000056073 (Evidence)
NCBI Gene

14806

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056073	Ensembl Gene Model \| MGI Sequence Detail	693934	C57BL/6J	± kb
transcript	ENSMUST00000105484	Ensembl \| MGI Sequence Detail	3992	Not Applicable
polypeptide	ENSMUSP00000101124	Ensembl \| MGI Sequence Detail	908	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000008241 glutamate receptor ionotropic, kainate 2

(term hierarchy)
InterPro Domains

IPR015683 Ionotropic glutamate receptor

IPR001320 Ionotropic glutamate receptor, C-terminal

IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain

IPR001508 Ionotropic glutamate receptor, metazoa

IPR028082 Periplasmic binding protein-like I

IPR001828 Receptor, ligand binding region
GlyGen

P39087 10 sites, 12 N-linked glycans (8 sites), 1 O-linked glycan (1 site)

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All nucleic 26

Genomic 2

cDNA 17

Primer pair 4

Other 3

Antibodies 1

Microarray probesets 7

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MGD-MRK-10145, MGD-MRK-10152, MGD-MRK-10253, MGI:2143816, MGI:2444432

Summaries

All 151

Developmental Gene Expression 23

Gene Ontology 44

Phenotypes 64
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:374537 Cai W, et al., The kainate receptor GluK2 mediates cold sensing in mice. Nat Neurosci. 2024 Apr;27(4):679-688

TSS for Grik2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97545	Chr10:49664839-49664865 (-)	10 bp
Tssr97544	Chr10:49659769-49659823 (-)	5,066 bp
Tssr97543	Chr10:49659586-49659678 (-)	5,230 bp
Tssr97542	Chr10:49599148-49599160 (-)	65,708 bp
Tssr97541	Chr10:49586729-49586735 (-)	78,130 bp
Tssr97540	Chr10:49410194-49410200 (-)	254,665 bp
Tssr97539	Chr10:49240521-49240546 (-)	424,328 bp
Tssr97538	Chr10:49148904-49148929 (-)	515,945 bp
Tssr97537	Chr10:49107986-49107993 (-)	556,872 bp
Tssr97535	Chr10:49094469-49094472 (-)	570,391 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24