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Grik2 Gene Detail
Summary
  • Symbol
    Grik2
  • Name
    glutamate receptor, ionotropic, kainate 2 (beta 2)
  • Synonyms
    Glur6, Glur-6, Glurbeta2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95815
    NCBI Gene: 14806
  • Gene Overview
    MyGene.info: GRIK2
Location & Maps
more
  • Sequence Map
    Chr10:49099460-49788766 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      689307 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 24.87 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GRIK2, glutamate ionotropic receptor kainate type subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRIK2, glutamate ionotropic receptor kainate type subunit 2
    Orthology source: HomoloGene
  • Synonyms
    EAA4, GLR6, GluK2, GLUK6, GLUR6, MRT6
  • Links
    NCBI Gene ID: 2898
    neXtProt AC: NX_Q13002

  • Chr Location
    6q16.3; chr6:101393708-102070083 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GRIK2 associations

Human Disease Mouse Models
       Mental Retardation, Autosomal Recessive 6; MRT6   OMIM: 611092
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Grik2
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit hippocampal neurons with reduced sensitivity to kainate and reduced susceptibility to the seizure-inducing effects of kainate administration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016255 VEGA Gene Model | MGI Sequence Detail 689307 C57BL/6J ±  kb
transcript OTTMUST00000038976 VEGA | MGI Sequence Detail 4800 Not Applicable  
polypeptide OTTMUSP00000017420 VEGA | MGI Sequence Detail 908 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3122 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000008241 glutamate receptor ionotropic, kainate 2
  • InterPro Domains
    IPR001320 Ionotropic glutamate receptor
    IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    IPR001508 Ionotropic glutamate receptor, metazoa
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 15
    Genomic 2
    cDNA 11
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-10145, MGD-MRK-10152, MGD-MRK-10253, MGI:2143816
References
more
  • Summaries
    All 91
    Developmental Gene Expression 15
    Gene Ontology 32
    Phenotypes 41
  • Earliest
    J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
  • Latest
    J:219340 Molyneaux BJ, et al., DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Neuron. 2015 Jan 21;85(2):275-88

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory