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Grik2
Gene Detail
 Symbol
Name
ID
Grik2
glutamate receptor, ionotropic, kainate 2 (beta 2)
MGI:95815
Synonyms Glur6, Glur-6, Glurbeta2
Feature Type protein coding gene
Genetic Map
Chromosome 10
24.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:49099460-49788766 bp, - strand
From VEGA annotation of GRCm38

  689307 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40717  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Grik2

Human
homologs
Human Homolog GRIK2, glutamate receptor, ionotropic, kainate 2
NCBI Gene ID 2898
neXtProt AC  NX_Q13002
Human Synonyms  EAA4, GLR6, GluK2, GLUK6, GLUR6, MRT6
Human Chr (Location)  6q16.3; chr6:101393708-102070083 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GRIK2
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit hippocampal neurons with reduced sensitivity to kainate and reduced susceptibility to the seizure-inducing effects of kainate administration.
 
Interactions
Grik2 interacts with 329 markers (Mir17, Mir18, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process behavioral fear response, cellular calcium ion homeostasis, ...
Component axon, cell, ...
Function extracellular-glutamate-gated ion channel activity, glutamate receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (250)    Tissues (94)    Images (26)
Theiler Stages: 21, 23, 26, 28
Assay TypeResults
RNA in situ 204
RT-PCR 46
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(2) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016255 (Evidence)
Ensembl Gene ModelENSMUSG00000056073 (Evidence)
Entrez Gene14806 (Evidence)
DFCITC1585400, TC1589585, TC1593867, TC1666100
DoTSDT.101150294, DT.101708686, DT.40139835, DT.55275289, DT.94232648
NIA Mouse Gene IndexU031764
Consensus CDS ProjectCCDS23830.1, CCDS48554.1
International Mouse Knockout Project StatusGrik2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016255 VEGA Gene Model | MGI Sequence Detail 689307 C57BL/6J ±  kb
transcript OTTMUST00000038976 VEGA | MGI Sequence Detail 4800 Not Applicable 
polypeptide OTTMUSP00000017420 VEGA | MGI Sequence Detail 908 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(16) UniProt(5)
Polymorphisms RFLP(2) : SNPs within 2kb(3152 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3158)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008241 glutamate receptor ionotropic, kainate 2
References (Earliest) J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
(Latest) J:210617 Fritsch B, et al., Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis. J Neurosci. 2014 Apr 23;34(17):5765-75
All references(94)
Other
accession IDs
MGD-MRK-10145, MGD-MRK-10152, MGD-MRK-10253, MGI:2143816

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory