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Grid2 Gene Detail
Summary
  • Symbol
    Grid2
  • Name
    glutamate receptor, ionotropic, delta 2
  • Synonyms
    B230104L07Rik, GluRdelta2, tpr
  • Feature Type
    protein coding gene
  • IDs
    MGI:95813
    NCBI Gene: 14804
  • Gene Overview
    MyGene.info: GRID2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:63255876-64704323 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1448448 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 29.77 cM
  • Mapping Data
    31 experiments
Homology
more
  • Human Ortholog
    GRID2, glutamate ionotropic receptor delta type subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRID2, glutamate ionotropic receptor delta type subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GluD2, SCAR18
  • Links
    NCBI Gene ID: 2895
    neXtProt AC: NX_O43424
    UniProt: O43424

  • Chr Location
    4q22.1-q22.2; chr4:92304249-93810330 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Grid2 mouse models; 1 with human GRID2 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    105 phenotypes from 29 alleles in 31 genetic backgrounds
    24 phenotypes from multigenic genotypes
    9 images
    208 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for multiple spontaneous and targeted null mutations exhibit ataxia and impaired locomotion associated with cerebellar Purkinje cell abnormalities and loss, and on some backgrounds, male infertility due to lack of zona penetration by sperm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034292 VEGA Gene Model | MGI Sequence Detail 1448448 C57BL/6J ±  kb
    transcript OTTMUST00000087192 VEGA | MGI Sequence Detail 5860 Not Applicable  
    polypeptide OTTMUSP00000047298 VEGA | MGI Sequence Detail 1007 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      8209 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008238 glutamate receptor ionotropic, delta-2
    • InterPro Domains
      IPR001320 Ionotropic glutamate receptor
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 14
      cDNA 16
      Primer pair 4
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10251, MGD-MRK-10810, MGD-MRK-11756, MGD-MRK-2116, MGI:1890672, MGI:2151352, MGI:2442634, MGI:3606121, MGI:96166, MGI:96754
    References
    more
    • Summaries
      All 287
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 17
      Phenotypes 208
    • Earliest
      J:289 Phillips RJS, "Lurcher", a new gene in linkage group XI of the house mouse. J Genet. 1960;57:35-42
    • Latest
      J:250846 Kotajima-Murakami H, et al., Involvement of GluD2 in Fear-Conditioned Bradycardia in Mice. PLoS One. 2016;11(11):e0166144

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory