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Grid2 Gene Detail
Summary
  • Symbol
    Grid2
  • Name
    glutamate receptor, ionotropic, delta 2
  • Synonyms
    B230104L07Rik, GluRdelta2, tpr
  • Feature Type
    protein coding gene
  • IDs
    MGI:95813
    NCBI Gene: 14804
  • Gene Overview
    MyGene.info: GRID2
Location & Maps
more
  • Sequence Map
    Chr6:63255876-64704323 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1448448 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 29.77 cM
  • Mapping Data
    31 experiments
Homology
more
  • Human Ortholog
    GRID2, glutamate ionotropic receptor delta type subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRID2, glutamate ionotropic receptor delta type subunit 2
    Orthology source: HomoloGene
  • Synonyms
    GluD2, SCAR18
  • Links
    NCBI Gene ID: 2895
    neXtProt AC: NX_O43424

  • Chr Location
    4q22; chr4:92304399-93774556 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Grid2 mouse models; 1 with human GRID2 associations

Human Disease Mouse Models
       Spinocerebellar Ataxia, Autosomal Recessive 18; SCAR18   OMIM: 616204 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    105 phenotypes from 29 alleles in 31 genetic backgrounds
    24 phenotypes from multigenic genotypes
    9 images
    206 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    34
  • Chemically induced (ENU)
    2
  • Gene trapped
    2
  • Spontaneous
    22
  • Targeted
    6
  • Transgenic
    2
  • Incidental Mutations
Homozygotes for multiple spontaneous and targeted null mutations exhibit ataxia and impaired locomotion associated with cerebellar Purkinje cell abnormalities and loss, and on some backgrounds, male infertility due to lack of zona penetration by sperm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034292 VEGA Gene Model | MGI Sequence Detail 1448448 C57BL/6J ±  kb
transcript OTTMUST00000087192 VEGA | MGI Sequence Detail 5860 Not Applicable  
polypeptide OTTMUSP00000047298 VEGA | MGI Sequence Detail 1007 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    8209 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008238 glutamate receptor ionotropic, delta-2
  • InterPro Domains
    IPR001320 Ionotropic glutamate receptor
    IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    IPR001508 Ionotropic glutamate receptor, metazoa
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 34
    Genomic 14
    cDNA 15
    Primer pair 4
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-10251, MGD-MRK-10810, MGD-MRK-11756, MGD-MRK-2116, MGI:1890672, MGI:2151352, MGI:2442634, MGI:3606121, MGI:96166, MGI:96754
References
more
  • Summaries
    All 273
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 14
    Phenotypes 206
  • Earliest
    J:289 Phillips RJS, "Lurcher", a new gene in linkage group XI of the house mouse. J Genet. 1960;57:35-42
  • Latest
    J:231814 Ichikawa R, et al., GluD2 Endows Parallel Fiber-Purkinje Cell Synapses with a High Regenerative Capacity. J Neurosci. 2016 Apr 27;36(17):4846-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory