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Gria4 Gene Detail
Summary
  • Symbol
    Gria4
  • Name
    glutamate receptor, ionotropic, AMPA4 (alpha 4)
  • Synonyms
    Glur4, Glur-4, Gluralpha4, spkw1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95811
    NCBI Gene: 14802
  • Gene Overview
    MyGene.info: GRIA4
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr9:4417896-4796234 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      378339 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    GRIA4, glutamate ionotropic receptor AMPA type subunit 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GRIA4, glutamate ionotropic receptor AMPA type subunit 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GluA4, GLUR4, GLUR4C, GLURD, NEDSGA
  • Links
    NCBI Gene ID: 2893
    neXtProt AC: NX_P48058
    UniProt: P48058

  • Chr Location
    11q22.3; chr11:105609994-105982092 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 6 alleles in 10 genetic backgrounds
    4 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation display hyperactivity, decreased thermal nociception, and abnormal sensitivity to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    344
  • Tissues
    153
  • cDNA Data
    31
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000061694 VEGA Gene Model | MGI Sequence Detail 378339 C57BL/6J ±  kb
    transcript OTTMUST00000150538 VEGA | MGI Sequence Detail 5352 Not Applicable  
    polypeptide OTTMUSP00000078043 VEGA | MGI Sequence Detail 902 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1758 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 1
      cDNA 35
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10143, MGD-MRK-10150, MGD-MRK-10249, MGI:3580137
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 15
      Gene Ontology 8
      Phenotypes 23
    • Earliest
      J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
    • Latest
      J:257523 Stroh S, et al., Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells. J Neurosci. 2018 Feb 21;38(8):2015-2028
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    09/11/2018
    MGI 6.12     		The Jackson Laboratory