Gria4 MGI Mouse Gene Detail - MGI:95811 - glutamate receptor, ionotropic, AMPA4 (alpha 4)

Gria4 Gene Detail

Symbol

Gria4
Name

glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms

Glur4, Glur-4, Gluralpha4, spkw1

Feature Type

protein coding gene
IDs

MGI:95811
NCBI Gene: 14802
Gene Overview

MyGene.info: GRIA4

Sequence Map

Chr9:4417896-4796234 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

378339 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 2.46 cM
Mapping Data

9 experiments

Human Ortholog

GRIA4, glutamate ionotropic receptor AMPA type subunit 4

Vertebrate Orthologs

7

Human Ortholog

GRIA4, glutamate ionotropic receptor AMPA type subunit 4
Orthology source: HomoloGene, HGNC
Synonyms

GluA4, GLUR4, GLUR4C, GLURD
Links

HGNC:4574

NCBI Gene ID: 2893

neXtProt AC: NX_P48058

UniProt: P48058
Chr Location

11q22.3; chr11:105609994-105982092 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20227
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 macaque, rhesus
HCOP

human homology predictions: GRIA4
Protein SuperFamily

ionotropic glutamate receptor, AMPA/kainate types
Gene Tree

Gria4

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Phenotype Summary

30 phenotypes from 6 alleles in 10 genetic backgrounds
4 phenotypes from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
QTL

1
Targeted

9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available

Mice homozygous for a targeted mutation display hyperactivity, decreased thermal nociception, and abnormal sensitivity to pharmacologically induced seizures.

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All GO Annotations

33
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

329
Tissues

149
cDNA Data

30
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN gria4a

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Gria4 interacts with 338 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

61
RefSeq

26
UniProt

6
CCDS

CCDS22797.1, CCDS52715.1, CCDS52716.1
UniGene

209263

			Length	Strain/Species	Flank
genomic	OTTMUSG00000061694	VEGA Gene Model \| MGI Sequence Detail	378339	C57BL/6J	± kb
transcript	OTTMUST00000150538	VEGA \| MGI Sequence Detail	5352	Not Applicable
polypeptide	OTTMUSP00000078043	VEGA \| MGI Sequence Detail	902	Not Applicable

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SNPs within 2kb

1758 from dbSNP Build 142

RFLP

1

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UniProt

6 Sequences
Protein Ontology

PR:000008236 glutamate receptor 4

(term hierarchy)
InterPro Domains

IPR001320 Ionotropic glutamate receptor

IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain

IPR001508 Ionotropic glutamate receptor, metazoa

IPR028082 Periplasmic binding protein-like I

IPR001828 Receptor, ligand binding region

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All nucleic 36

Genomic 1

cDNA 34

Primer pair 1

Microarray probesets 5

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MGD-MRK-10143, MGD-MRK-10150, MGD-MRK-10249, MGI:3580137

Summaries

All 77

Developmental Gene Expression 12

Gene Ontology 7

Phenotypes 18
Earliest

J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
Latest

J:238439 Sarowar T, et al., Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2. Mol Brain. 2016 Mar 11;9:28

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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