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Gria4 Gene Detail
Summary
  • Symbol
    Gria4
  • Name
    glutamate receptor, ionotropic, AMPA4 (alpha 4)
  • Synonyms
    Glur-4, Glur4, Gluralpha4, spkw1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95811
    NCBI Gene: 14802
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:4417896-4796234 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    19112 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95811
 protein coding gene Chr9:4417893-4796250 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034311
 protein coding gene Chr9:1138264-1535750 (-)
A/J MGP_AJ_G0034288
 protein coding gene Chr9:1291638-1679365 (-)
AKR/J MGP_AKRJ_G0034218
 protein coding gene Chr9:1149261-1525161 (-)
BALB/cJ MGP_BALBcJ_G0034282
 protein coding gene Chr9:1080951-1467730 (-)
C3H/HeJ MGP_C3HHeJ_G0033994
 protein coding gene Chr9:1305716-1706781 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034804
 protein coding gene Chr9:1252724-1683823 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031742
 protein coding gene Chr9:901982-1275664 (-)
CAST/EiJ MGP_CASTEiJ_G0033321
 protein coding gene Chr9:1376894-1762801 (-)
CBA/J MGP_CBAJ_G0033966
 protein coding gene Chr9:1183807-1623210 (-)
DBA/2J MGP_DBA2J_G0034123
 protein coding gene Chr9:1249493-1629428 (-)
FVB/NJ MGP_FVBNJ_G0034068
 protein coding gene Chr9:1082946-1462225 (-)
LP/J MGP_LPJ_G0034210
 protein coding gene Chr9:1171050-1562212 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034112
 protein coding gene Chr9:1571026-2028439 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034823
 protein coding gene Chr9:1124902-1508454 (-)
PWK/PhJ MGP_PWKPhJ_G0033025
 protein coding gene Chr9:1382836-1754713 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032862
 protein coding gene Chr9:1402175-1778324 (-)
WSB/EiJ MGP_WSBEiJ_G0033437
 protein coding gene Chr9:1160287-1540672 (-)



Homology
more
  • Human Ortholog
    GRIA4, glutamate ionotropic receptor AMPA type subunit 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIA4, glutamate ionotropic receptor AMPA type subunit 4
  • Synonyms
    GluA4, GluA4-ATD, GLUR4, GLUR4C, GLURD, NEDSGA
  • Links
    NCBI Gene ID: 2893
    UniProt: P48058

  • Chr Location
    11q22.3; chr11:105609535-105982090 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GRIA4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 6 alleles in 10 genetic backgrounds
    4 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation display hyperactivity, decreased thermal nociception, and abnormal sensitivity to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1074
  • Tissues
    170
  • cDNA Data
    31
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025892 Ensembl Gene Model | MGI Sequence Detail 378339 C57BL/6J ±  kb
    transcript ENSMUST00000063508 Ensembl | MGI Sequence Detail 5352 Not Applicable  
    polypeptide ENSMUSP00000066980 Ensembl | MGI Sequence Detail 902 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000008236 glutamate receptor 4
      (term hierarchy)
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      Q9Z2W8 7 sites, 10 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 1
      cDNA 36
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10143, MGD-MRK-10150, MGD-MRK-10249, MGI:3580137
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 17
      Gene Ontology 15
      Phenotypes 31
    • Earliest
      J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
    • Latest
      J:360511 Wang X, et al., Restoration of nNOS Expression Rescues Autistic-Like Phenotypes Through Normalization of AMPA Receptor-Mediated Neurotransmission. Mol Neurobiol. 2024 Sep;61(9):6599-6612
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    03/25/2025
    MGI 6.24     		The Jackson Laboratory