Gria4
Gene Detail

Symbol

Name
ID

Gria4
glutamate receptor, ionotropic, AMPA4 (alpha 4)
MGI:95811

Synonyms

Glur4, Glur-4, Gluralpha4, spkw1

Feature Type

protein coding gene

Genetic Map

Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr9:4417899-4796234 bp, - strand From Ensembl annotation of GRCm38   378336 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:20227  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Gria4

Human
homologs

Human Homolog		GRIA4, glutamate receptor, ionotropic, AMPA 4
NCBI Gene ID		2893
neXtProt AC		NX_P48058
Human Synonyms		GluA4, GLUR4, GLUR4C, GLURD
Human Chr (Location)		11q22; chr11:105609994-105982092 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(10) : QTL(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a targeted mutation display hyperactivity, decreased thermal nociception, and abnormal sensitivity to pharmacologically induced seizures.

 

Interactions

Gria4 interacts with 338 markers (Mir1b, Mir7-1, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (38 annotations)

Process	ionotropic glutamate receptor signaling pathway, ion transmembrane transport, ...
Component	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex, cell junction, ...
Function	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity, extracellular-glutamate-gated ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)

Data Summary: Results (329)    Tissues (149)    Images (34)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	259
In situ reporter (knock in)	32
RT-PCR	38

cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(36) Genomic(1) cDNA(34) Primer pair(1)
Microarray probesets(5)

Other database
links

Ensembl Gene Model	ENSMUSG00000025892 (Evidence)
Entrez Gene	14802 (Evidence)
UniGene	209263
DFCI	TC1580146, TC1587971, TC1596069
DoTS	DT.55178948, DT.91336086, DT.99848771
NIA Mouse Gene Index	U030434
Consensus CDS Project	CCDS22797.1, CCDS52715.1, CCDS52716.1
International Mouse Knockout Project Status	Gria4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000025892	Ensembl Gene Model | MGI Sequence Detail	378336	C57BL/6J
transcript	ENSMUST00000027020	Ensembl | MGI Sequence Detail	5441	Not Applicable
polypeptide	ENSMUSP00000027020	Ensembl | MGI Sequence Detail	902	Not Applicable

All sequences(58) RefSeq(20) UniProt(11)

Polymorphisms

RFLP(1) : SNPs within 2kb(1796 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1806)

Protein-related
information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR019594	Glutamate receptor, L-glutamate/glycine-binding
InterPro	IPR001320	Ionotropic glutamate receptor
InterPro	IPR001508	NMDA receptor
Protein Ontology	PR:000008236	glutamate receptor 4

References

(Earliest) J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
(Latest) J:208419 Basta JM, et al., Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58
All references(77)

Other
accession IDs

MGD-MRK-10143, MGD-MRK-10150, MGD-MRK-10249, MGI:3580137