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Gria4 Gene Detail
Summary
  • Symbol
    Gria4
  • Name
    glutamate receptor, ionotropic, AMPA4 (alpha 4)
  • Synonyms
    Glur4, Glur-4, Gluralpha4, spkw1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95811
    NCBI Gene: 14802
  • Gene Overview
    MyGene.info: GRIA4
Location & Maps
more
  • Sequence Map
    Chr9:4417899-4796234 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      378336 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    GRIA4, glutamate ionotropic receptor AMPA type subunit 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GRIA4, glutamate ionotropic receptor AMPA type subunit 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GluA4, GLUR4, GLUR4C, GLURD
  • Links
    NCBI Gene ID: 2893
    neXtProt AC: NX_P48058

  • Chr Location
    11q22; chr11:105609994-105982092 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 6 alleles in 9 genetic backgrounds
    2 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation display hyperactivity, decreased thermal nociception, and abnormal sensitivity to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    31
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    329
  • Tissues
    149
  • cDNA Data
    30
  • Literature Summary
    12
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025892 Ensembl Gene Model | MGI Sequence Detail 378336 C57BL/6J ±  kb
transcript ENSMUST00000027020 Ensembl | MGI Sequence Detail 5441 Not Applicable  
polypeptide ENSMUSP00000027020 Ensembl | MGI Sequence Detail 902 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1758 from dbSNP Build 142
  • RFLP
    1
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000008236 glutamate receptor 4
  • InterPro Domains
    IPR001320 Ionotropic glutamate receptor
    IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    IPR001508 Ionotropic glutamate receptor, metazoa
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 36
    Genomic 1
    cDNA 34
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-10143, MGD-MRK-10150, MGD-MRK-10249, MGI:3580137
References
more
  • Summaries
    All 74
    Developmental Gene Expression 12
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
  • Latest
    J:231740 Yamasaki M, et al., TARP gamma-2 and gamma-8 Differentially Control AMPAR Density Across Schaffer Collateral/Commissural Synapses in the Hippocampal CA1 Area. J Neurosci. 2016 Apr 13;36(15):4296-312
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory