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Gria3
Gene Detail
 Symbol
Name
ID
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
MGI:95810
Synonyms 2900064I19Rik, Glur3, Glur-3, GluR3, Gluralpha3
Feature Type protein coding gene
Genetic Map
Chromosome X
23.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:41400854-41678601 bp, + strand
From VEGA annotation of GRCm38

  277748 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37353  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Gria3

Human
homologs
Human Homolog GRIA3, glutamate receptor, ionotropic, AMPA 3
NCBI Gene ID 2892
neXtProt AC  NX_P42263
Human Synonyms  GluA3, GLUR3, GLURC, GLUR-C, GLUR-K3, MRX94
Human Chr (Location)  Xq25; chrX:123184243-123490915 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GRIA3
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from APF )
 
Male mice hemizygous for one allele display reduced fertility and enhanced long term potentiation. Male mice hemizygous for a second allele display decreased thermal nociception, resistance to drug induced seizures and a decreased startle reflex; and homozygous female mice have decreased body weight
 
Interactions
Gria3 interacts with 444 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process ionotropic glutamate receptor signaling pathway, ion transmembrane transport, ...
Component alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex, asymmetric synapse, ...
Function alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity, extracellular-glutamate-gated ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (130)    Tissues (85)    Images (48)
Theiler Stages: 23, 26, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 24
In situ reporter (knock in) 62
Western blot 1
RT-PCR 38
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) Genomic(1) cDNA(42) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017323 (Evidence)
Ensembl Gene ModelENSMUSG00000001986 (Evidence)
Entrez Gene53623 (Evidence)
UniGene327681
DFCITC1585934, TC1613408, TC1632104, TC1650057, TC1661534
DoTSDT.101321209, DT.101342209, DT.111020311, DT.40181800, DT.60117399, DT.91594209, DT.91596227
NIA Mouse Gene IndexU043754
PDB3LSW, 3LSX
Consensus CDS ProjectCCDS30097.1, CCDS72370.1
International Mouse Knockout Project StatusGria3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017323 VEGA Gene Model | MGI Sequence Detail 277748 C57BL/6J ±  kb
transcript OTTMUST00000077889 VEGA | MGI Sequence Detail 3081 Not Applicable 
polypeptide OTTMUSP00000041292 VEGA | MGI Sequence Detail 888 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(9) UniProt(11)
Polymorphisms RFLP(1) : SNPs within 2kb(582 from dbSNP Build 137)    SNPs within 2kb including multiple locations(584)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008235 glutamate receptor 3
References (Earliest) J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
(Latest) J:208015 Xiang J, et al., Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting. J Clin Invest. 2014 Jan 2;124(1):85-98
All references(96)
Other
accession IDs
MGD-MRK-10142, MGD-MRK-10149, MGD-MRK-10248, MGI:1920286

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory