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Gria3
Gene Detail
Symbol

Name
ID
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
MGI:95810
Synonyms
2900064I19Rik, Glur3, Glur-3, GluR3, Gluralpha3
Feature Type
protein coding gene
Genetic Map
Chromosome X
23.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:41400854-41678601 bp, + strand
From VEGA annotation of GRCm38

  277748 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37353  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GRIA3
Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Gria3

Human
homologs
GRIA3, glutamate receptor, ionotropic, AMPA 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2892
neXtProt AC: NX_P42263

Human Synonyms: GluA3, GLUR3, GLURC, GLUR-C, GLUR-K3, MRX94

Human Chr (Location): Xq25; chrX:123184243-123490915 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GRIA3

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from APF , CvDC )
 
Male mice hemizygous for one allele display reduced fertility and enhanced long term potentiation. Male mice hemizygous for a second allele display decreased thermal nociception, resistance to drug induced seizures and a decreased startle reflex; and homozygous female mice have decreased body weight
 
Interactions
Gria3 interacts with 443 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (20 records)
Data Summary: Results (130)    Tissues (85)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 24
In situ reporter (knock in) 62
Western blot 1
RT-PCR 38
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gria3    NEW 
Molecular
reagents
All nucleic(44) Genomic(1) cDNA(42) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000017323 (Evidence)
Ensembl Gene Model ENSMUSG00000001986 (Evidence)
Entrez Gene 53623 (Evidence)
UniGene 327681
DFCI TC1585934, TC1613408, TC1632104, TC1650057, TC1661534
DoTS DT.101321209, DT.101342209, DT.111020311, DT.40181800, DT.60117399, DT.91594209, DT.91596227
NIA Mouse Gene Index U043754
PDB 3LSW, 3LSX
Consensus CDS Project CCDS30097.1, CCDS72370.1
International Mouse Phenotyping Consortium Status Gria3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017323 VEGA Gene Model | MGI Sequence Detail 277748 C57BL/6J ±  kb
transcript OTTMUST00000077886 VEGA | MGI Sequence Detail 5192 Not Applicable 
polypeptide OTTMUSP00000041290 VEGA | MGI Sequence Detail 888 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(11) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(582 from dbSNP Build 137)    SNPs within 2kb including multiple locations(584)
Protein-related
information
ResourceIDDescription
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
InterPro IPR001508 Ionotropic glutamate receptor, metazoa
InterPro IPR028082 Periplasmic binding protein-like I
InterPro IPR001828 Receptor, ligand binding region
Protein Ontology PR:000008235 glutamate receptor 3
References
(Earliest) J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
(Latest) J:208015 Xiang J, et al., Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting. J Clin Invest. 2014 Jan 2;124(1):85-98
All references(93)
Other
accession IDs
MGD-MRK-10142, MGD-MRK-10149, MGD-MRK-10248, MGI:1920286

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory