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Gria3 Gene Detail
Summary
  • Symbol
    Gria3
  • Name
    glutamate receptor, ionotropic, AMPA3 (alpha 3)
  • Synonyms
    2900064I19Rik, Glur3, Glur-3, GluR3, Gluralpha3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95810
    NCBI Gene: 53623
  • Gene Overview
    MyGene.info: GRIA3
Location & Maps
more
  • Sequence Map
    ChrX:41400854-41678601 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      277748 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 23.19 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    GRIA3, glutamate ionotropic receptor AMPA type subunit 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GRIA3, glutamate ionotropic receptor AMPA type subunit 3
    Orthology source: HomoloGene
  • Synonyms
    GluA3, GLUR3, GLURC, GLUR-C, GLUR-K3, MRX94
  • Links
    NCBI Gene ID: 2892
    neXtProt AC: NX_P42263

  • Chr Location
    Xq25; chrX:123184243-123490915 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GRIA3 associations

Human Disease Mouse Models
       Mental Retardation, X-Linked, Syndromic, Wu Type; MRXSW   OMIM: 300699
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 5 alleles in 5 genetic backgrounds
    12 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Targeted
    8
  • Incidental Mutations
    APF , CvDC
Male mice hemizygous for one allele display reduced fertility and enhanced long term potentiation. Male mice hemizygous for a second allele display decreased thermal nociception, resistance to drug induced seizures and a decreased startle reflex; and homozygous female mice have decreased body weight
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017323 VEGA Gene Model | MGI Sequence Detail 277748 C57BL/6J ±  kb
transcript OTTMUST00000077889 VEGA | MGI Sequence Detail 3081 Not Applicable  
polypeptide OTTMUSP00000041292 VEGA | MGI Sequence Detail 888 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    575 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000008235 glutamate receptor 3
  • PDB
  • InterPro Domains
    IPR001320 Ionotropic glutamate receptor
    IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    IPR001508 Ionotropic glutamate receptor, metazoa
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 44
    Genomic 1
    cDNA 42
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10142, MGD-MRK-10149, MGD-MRK-10248, MGI:1920286
References
more
  • Summaries
    All 92
    Developmental Gene Expression 21
    Gene Ontology 9
    Phenotypes 20
  • Earliest
    J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
  • Latest
    J:231740 Yamasaki M, et al., TARP gamma-2 and gamma-8 Differentially Control AMPAR Density Across Schaffer Collateral/Commissural Synapses in the Hippocampal CA1 Area. J Neurosci. 2016 Apr 13;36(15):4296-312

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory