Gria3
Gene Detail

Symbol Name ID

Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3) MGI:95810

Synonyms

2900064I19Rik, Glur3, Glur-3, GluR3, Gluralpha3

Feature Type

protein coding gene

Genetic Map

Chromosome X

23.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

ChrX:41400854-41678601 bp, + strand From VEGA annotation of GRCm38   277748 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37353  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Gria3

Human homologs

Human Homolog		GRIA3, glutamate receptor, ionotropic, AMPA 3
NCBI Gene ID		2892
neXtProt AC		NX_P42263
Human Synonyms		GluA3, GLUR3, GLURC, GLUR-C, GLUR-K3, MRX94
Human Chr (Location)		Xq25; chrX:122318096-122624766 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GRIA3

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Male mice hemizygous for one allele display reduced fertility and enhanced long term potentiation. Male mice hemizygous for a second allele display decreased thermal nociception, resistance to drug induced seizures and a decreased startle reflex; and homozygous female mice have decreased body weight

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	ionotropic glutamate receptor signaling pathway, ion transport, ...
Component	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex, asymmetric synapse, ...
Function	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity, extracellular-glutamate-gated ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (130)    Tissues (85)    Images (48)
Theiler Stages: 23, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	24
In situ reporter (knock in)	62
Western blot	1
RT-PCR	38

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) Genomic(1) cDNA(42) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000017323 (Evidence)
Ensembl Gene Model	ENSMUSG00000001986 (Evidence)
Entrez Gene	53623 (Evidence)
UniGene	327681
DFCI	TC1585934, TC1613408, TC1632104, TC1650057, TC1661534
DoTS	DT.101321209, DT.101342209, DT.111020311, DT.40181800, DT.60117399, DT.91594209, DT.91596227
NIA Mouse Gene Index	U043754
PDB	3LSW
Consensus CDS Project	CCDS30097.1
International Mouse Knockout Project Status	Gria3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017323	VEGA Gene Model | MGI Sequence Detail	277748	C57BL/6J
transcript	OTTMUST00000077886	VEGA | MGI Sequence Detail	5192	Not Applicable
polypeptide	OTTMUSP00000041290	VEGA | MGI Sequence Detail	888	Not Applicable

All sequences(77) RefSeq(2) UniProt(11)

Polymorphisms

RFLP(1) : SNPs(541 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR019594	Glutamate receptor, L-glutamate/glycine-binding
InterPro	IPR001320	Ionotropic glutamate receptor
InterPro	IPR001508	NMDA receptor
Protein Ontology	PR:000008235	glutamate receptor 3

References

(Earliest) J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
(Latest) J:191674 Miyamoto M, et al., Involvement of AMPA receptor GluR2 and GluR3 trafficking in trigeminal spinal subnucleus caudalis and C1/C2 neurons in acute-facial inflammatory pain. PLoS One. 2012;7(8):e44055
All references(93)

Other accession IDs

MGD-MRK-10142, MGD-MRK-10149, MGD-MRK-10248, MGI:1920286