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Gria3 Gene Detail
Summary
  • Symbol
    Gria3
  • Name
    glutamate receptor, ionotropic, AMPA3 (alpha 3)
  • Synonyms
    2900064I19Rik, Glur3, Glur-3, GluR3, Gluralpha3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95810
    NCBI Gene: 53623
  • Gene Overview
    MyGene.info: GRIA3
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:41401118-41678601 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 23.19 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    575 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95810
protein coding gene ChrX:41400854-41678601 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035672
protein coding gene ChrX:36431190-36719506 (+)
A/J MGP_AJ_G0035655
protein coding gene ChrX:36439386-36717908 (+)
AKR/J MGP_AKRJ_G0035575
protein coding gene ChrX:37309885-37578910 (+)
BALB/cJ MGP_BALBcJ_G0035641
protein coding gene ChrX:36121918-36394176 (+)
C3H/HeJ MGP_C3HHeJ_G0035345
protein coding gene ChrX:36783562-37060675 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036170
protein coding gene ChrX:37262905-37561118 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033022
protein coding gene ChrX:34582547-34847256 (+)
CAST/EiJ MGP_CASTEiJ_G0034636
protein coding gene ChrX:24634745-24912775 (+)
CBA/J MGP_CBAJ_G0035319
protein coding gene ChrX:38237138-38532130 (+)
DBA/2J MGP_DBA2J_G0035473
protein coding gene ChrX:36234358-36512809 (+)
FVB/NJ MGP_FVBNJ_G0035422
protein coding gene ChrX:35964085-36235889 (+)
LP/J MGP_LPJ_G0035561
protein coding gene ChrX:36793953-37073153 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035460
protein coding gene ChrX:38951040-39235863 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036188
protein coding gene ChrX:36420969-36690708 (+)
PWK/PhJ MGP_PWKPhJ_G0034335
protein coding gene ChrX:24208922-24474117 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034180
protein coding gene ChrX:25164726-25465927 (+)
WSB/EiJ MGP_WSBEiJ_G0034780
protein coding gene ChrX:36048853-36329567 (+)



Homology
more
  • Human Ortholog
    GRIA3, glutamate ionotropic receptor AMPA type subunit 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GRIA3, glutamate ionotropic receptor AMPA type subunit 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GluA3, GLUR3, GLURC, GLUR-C, GLUR-K3, MRX94
  • Links
    NCBI Gene ID: 2892
    neXtProt AC: NX_P42263
    UniProt: P42263

  • Chr Location
    Xq25; chrX:123184243-123490915 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human GRIA3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 5 alleles in 5 genetic backgrounds
    12 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice hemizygous for one allele display reduced fertility and enhanced long term potentiation. Male mice hemizygous for a second allele display decreased thermal nociception, resistance to drug induced seizures and a decreased startle reflex; and homozygous female mice have decreased body weight
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53623 NCBI Gene Model | MGI Sequence Detail 277484 C57BL/6J ±  kb
    transcript NM_001358361 RefSeq | MGI Sequence Detail 5389 C57BL/6  
    polypeptide Q9Z2W9 UniProt | EBI | MGI Sequence Detail 888 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • PDB
    • InterPro Domains
      IPR001320 Ionotropic glutamate receptor
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 1
      cDNA 43
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10142, MGD-MRK-10149, MGD-MRK-10248, MGI:1920286
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 24
      Gene Ontology 12
      Phenotypes 32
    • Earliest
      J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
    • Latest
      J:261481 Sheng N, et al., LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3948-3953

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory