About   Help   FAQ
Gria2 Gene Detail
Summary
  • Symbol
    Gria2
  • Name
    glutamate receptor, ionotropic, AMPA2 (alpha 2)
  • Synonyms
    GluA2, Glur2, Glur-2, GluR2, GluR-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:95809
    NCBI Gene: 14800
  • Gene Overview
    MyGene.info: GRIA2
Location & Maps
more
  • Sequence Map
    Chr3:80681450-80802835 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      121386 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 35.50 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    GRIA2, glutamate ionotropic receptor AMPA type subunit 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GRIA2, glutamate ionotropic receptor AMPA type subunit 2
    Orthology source: HomoloGene
  • Synonyms
    GluA2, GLUR2, GLURB, GluR-K2, HBGR2
  • Links
    NCBI Gene ID: 2891
    neXtProt AC: NX_P42262

  • Chr Location
    4q32.1; chr4:157220584-157366075 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    72 phenotypes from 14 alleles in 16 genetic backgrounds
    20 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    16
  • Transgenic
    1
  • Genomic Mutations
    2 involving Gria2
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit epilepsy, deficient dendritic architecture, altered exploratory behavior, impaired motor and learning performance, and increased mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051468 VEGA Gene Model | MGI Sequence Detail 121386 C57BL/6J ±  kb
transcript OTTMUST00000130045 VEGA | MGI Sequence Detail 10371 Not Applicable  
polypeptide OTTMUSP00000069772 VEGA | MGI Sequence Detail 883 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    706 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000008234 glutamate receptor 2
  • InterPro Domains
    IPR001320 Ionotropic glutamate receptor
    IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    IPR001508 Ionotropic glutamate receptor, metazoa
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
less
  • All nucleic 27
    Genomic 6
    cDNA 20
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-10141, MGD-MRK-10148, MGD-MRK-10247
References
more
  • Summaries
    All 173
    Developmental Gene Expression 34
    Gene Ontology 22
    Phenotypes 59
  • Earliest
    J:10801 Sakimura K, et al., Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Lett. 1990 Oct 15;272(1-2):73-80
  • Latest
    J:231740 Yamasaki M, et al., TARP gamma-2 and gamma-8 Differentially Control AMPAR Density Across Schaffer Collateral/Commissural Synapses in the Hippocampal CA1 Area. J Neurosci. 2016 Apr 13;36(15):4296-312

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory