Gria2 MGI Mouse Gene Detail - MGI:95809 - glutamate receptor, ionotropic, AMPA2 (alpha 2)

Symbol

Gria2
Name

glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms

GluA2, Glur-2, Glur2, GluR2, GluR-B

Feature Type

protein coding gene
IDs

MGI:95809
NCBI Gene: 14800
Alliance

genome feature page
Transcription Start Sites

17 TSS

Sequence Map

Chr3:80588757-80710142 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 35.50 cM
Mapping Data

5 experiments

SNPs within 2kb

3400 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95809	protein coding gene	Chr3:80588757-80711534 (-)
129S1/SvImJ	ENSMUSG00200019023	protein coding gene	Chr3:77428659-77543453 (-)
A/J	ENSMUSG00195011575	protein coding gene	Chr3:77435937-77550730 (-)
AKR/J	ENSMUSG00220001339	protein coding gene	Chr3:77445278-77568743 (-)
BALB/cJ	ENSMUSG00180001762	protein coding gene	Chr3:77533399-77654827 (-)
C3H/HeJ	ENSMUSG00175007245	protein coding gene	Chr3:77366813-77481619 (-)
C57BL/6NJ	ENSMUSG00215001953	protein coding gene	Chr3:77828553-77949958 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025091	protein coding gene	Chr3:73603768-73722255 (-)
CAST/EiJ	ENSTCUG00005001559	protein coding gene	Chr3:76938719-77054840 (-)
CBA/J	ENSMUSG00210025467	protein coding gene	Chr3:77473521-77588320 (-)
DBA/2J	ENSMUSG00185012389	protein coding gene	Chr3:77618107-77739532 (-)
FVB/NJ	ENSMUSG00205005924	protein coding gene	Chr3:76448806-76568339 (-)
JF1/MsJ	ENSUMUG00000000969	protein coding gene	Chr3:77194265-77309519 (-)
LP/J	ENSMUSG00230008728	protein coding gene	Chr3:79641132-79755934 (-)
NOD/ShiLtJ	ENSMUSG00190002658	protein coding gene	Chr3:77894786-78016163 (-)
NZO/HlLtJ	ENSMUSG00225006704	protein coding gene	Chr3:82342336-82457078 (-)
PWK/PhJ	ENSLUMG00010006132	protein coding gene	Chr3:77259035-77374090 (-)
SPRET/EiJ	ENSMSPG00010016234	protein coding gene	Chr3:78016774-78125740 (-)
WSB/EiJ	ENSIUOG00005002986	protein coding gene	Chr3:77857400-77972203 (-)

Human Ortholog

GRIA2, glutamate ionotropic receptor AMPA type subunit 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRIA2, glutamate ionotropic receptor AMPA type subunit 2
Synonyms

GluA2, gluR-2, GLUR2, gluR-B, GLURB, GluR-K2, HBGR2, NEDLIB
Links

HGNC:4572

NCBI Gene ID: 2891

UniProt: P42262
Chr Location

4q32.1; chr4:157204182-157387146 (+) GRCh38

MGI Vertebrate Homology

Gria2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GRIA2
Gene Tree

Gria2

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References

1 with disease annotations

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Phenotype Summary

76 phenotypes from 15 alleles in 17 genetic backgrounds
20 phenotypes from multigenic genotypes
128 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (other)

1
Endonuclease-mediated

8
Radiation induced

1
Targeted

19
Transgenic

1
Genomic Mutations

2 involving Gria2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

78 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit epilepsy, deficient dendritic architecture, altered exploratory behavior, impaired motor and learning performance, and increased mortality.

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All GO Annotations

147
GO References

35

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

848
Tissues

110
cDNA Data

21
Literature Summary

81

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gria2

ZFIN gria2a, gria2b

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All Sequences

110
RefSeq

41
UniProt

9
CCDS

CCDS17423.1, CCDS38459.1

Ensembl

ENSMUSG00000033981 (Evidence)
NCBI Gene

14800

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033981	Ensembl Gene Model \| MGI Sequence Detail	121386	C57BL/6J	± kb
transcript	ENSMUST00000075316	Ensembl \| MGI Sequence Detail	10371	Not Applicable
polypeptide	ENSMUSP00000074787	Ensembl \| MGI Sequence Detail	883	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000008234 glutamate receptor 2

(term hierarchy)
PDB

7LDD, 7LDE, 7LEP, 9Z6U, 9Z6V, 9Z6W
InterPro Domains

IPR015683 Ionotropic glutamate receptor

IPR001320 Ionotropic glutamate receptor, C-terminal

IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain

IPR001508 Ionotropic glutamate receptor, metazoa

IPR028082 Periplasmic binding protein-like I

IPR001828 Receptor, ligand binding region
GlyGen

P23819 5 sites, 13 N-linked glycans (4 sites), 1 O-linked glycan (1 site)

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All nucleic 36

Genomic 6

cDNA 24

Primer pair 4

Other 2

Antibodies 14

Microarray probesets 8

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MGD-MRK-10141, MGD-MRK-10148, MGD-MRK-10247

Summaries

All 347

Developmental Gene Expression 81

Diseases 1

Gene Ontology 35

Phenotypes 128
Earliest

J:10801 Sakimura K, et al., Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Lett. 1990 Oct 15;272(1-2):73-80
Latest

J:390257 Gao S, et al., Mll5 haploinsufficiency attenuates microglial phagocytosis through dysregulated TREM2-SGK3-GSK3beta signaling and recapitulates ASD-like behaviors in mice. Nat Commun. 2026 Apr 17;17(1)

TSS for Gria2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr33771	Chr3:80710096-80710147 (-)	20 bp
Tssr33770	Chr3:80710052-80710077 (-)	77 bp
Tssr33769	Chr3:80709986-80710037 (-)	130 bp
Tssr33768	Chr3:80709958-80709979 (-)	173 bp
Tssr33767	Chr3:80709940-80709951 (-)	196 bp
Tssr33766	Chr3:80709911-80709924 (-)	224 bp
Tssr33765	Chr3:80709897-80709908 (-)	239 bp
Tssr33764	Chr3:80705287-80705303 (-)	4,847 bp
Tssr33763	Chr3:80624795-80624797 (-)	85,346 bp
Tssr33762	Chr3:80598444-80598453 (-)	111,693 bp
Tssr33761	Chr3:80595781-80595795 (-)	114,354 bp
Tssr33760	Chr3:80595752-80595773 (-)	114,379 bp
Tssr33759	Chr3:80595644-80595672 (-)	114,484 bp
Tssr33758	Chr3:80595626-80595641 (-)	114,508 bp
Tssr33757	Chr3:80595575-80595612 (-)	114,548 bp
Tssr33756	Chr3:80595442-80595453 (-)	114,694 bp
Tssr33755	Chr3:80595423-80595437 (-)	114,712 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24