Grb2
Gene Detail

Symbol Name ID

Grb2 growth factor receptor bound protein 2 MGI:95805

Feature Type

protein coding gene

Genetic Map

Chromosome 11

80.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr11:115644045-115708597 bp, - strand From VEGA annotation of GRCm38   64553 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1576  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Grb2

Human homologs

Human Homolog		GRB2, growth factor receptor-bound protein 2
NCBI Gene ID		2885
neXtProt AC		NX_P62993
Human Synonyms		ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2
Human Chr (Location)		17q24-q25; chr17:73314157-73401790 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(58) : Targeted(6) Gene trapped(52)
 

Embryos homozygous for a targeted null mutation lack expanded inner cell masses, show only a few endodermal cells, and die by embryonic day 7.5. Heterozygotes have defective T cell signaling and lack the cardiac hypertrophy response to pressure overload.

 

Gene Ontology (GO) classifications

All GO classifications: (59 annotations)

Process	aging, anatomical structure formation involved in morphogenesis, ...
Component	cytoplasm, endosome, ...
Function	ephrin receptor binding, epidermal growth factor receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (183)    Tissues (99)    Images (4)
Theiler Stages: 13, 15, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	71
Northern blot	13
Western blot	7
RT-PCR	92

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000003535 (Evidence)
Ensembl Gene Model	ENSMUSG00000059923 (Evidence)
Entrez Gene	14784 (Evidence)
DFCI	TC1572299, TC1735347
DoTS	DT.101131742, DT.101301126, DT.110806633, DT.87069284, DT.97335710
PDB	1GBQ, 1GBR, 2GBQ, 3GBQ, 4GBQ
Consensus CDS Project	CCDS25645.1
International Mouse Knockout Project Status	Grb2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003535	VEGA Gene Model | MGI Sequence Detail	64553	C57BL/6J
transcript	OTTMUST00000007575	VEGA | MGI Sequence Detail	2683	Not Applicable
polypeptide	OTTMUSP00000003660	VEGA | MGI Sequence Detail	217	Not Applicable

All sequences(73) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(163 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000108	Neutrophil cytosol factor 2 p67phox
InterPro	IPR000980	SH2 domain
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR011511	Variant SH3
Protein Ontology	PR:000008224	growth factor receptor-bound protein 2

References

(Earliest) J:23345 Lowenstein EJ, et al., The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell. 1992 Aug 7;70(3):431-42
(Latest) J:189787 Lesourne R, et al., Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function. J Immunol. 2012 Aug 1;189(3):1154-61
All references(108)

Other accession IDs

MGD-MRK-10242, MGI:2143976