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Grb2
Gene Detail
Symbol

Name
ID
Grb2
growth factor receptor bound protein 2
MGI:95805
Feature Type
protein coding gene
Genetic Map
Chromosome 11
80.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:115644045-115708597 bp, - strand
From VEGA annotation of GRCm38

  64553 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1576  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Grb2

Human
homologs
Human Homolog GRB2, growth factor receptor-bound protein 2
NCBI Gene ID 2885
neXtProt AC  NX_P62993
Human Synonyms  ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2
Human Chr (Location)  17q24-q25; chr17:75318076-75405709 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(60) : Gene trapped(52) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a targeted null mutation lack expanded inner cell masses, show only a few endodermal cells, and die by embryonic day 7.5. Heterozygotes have defective T cell signaling and lack the cardiac hypertrophy response to pressure overload.
 
Interactions
Grb2 interacts with 274 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process aging, anatomical structure formation involved in morphogenesis, ...
Component cell-cell junction, COP9 signalosome, ...
Function ephrin receptor binding, epidermal growth factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (183)    Tissues (106)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 71
Northern blot 13
Western blot 7
RT-PCR 92
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000003535 (Evidence)
Ensembl Gene ModelENSMUSG00000059923 (Evidence)
Entrez Gene14784 (Evidence)
DFCITC1572299, TC1735347
DoTSDT.101131742, DT.101301126, DT.110806633, DT.87069284, DT.97335710
PDB1GBQ, 1GBR, 2GBQ, 3GBQ, 4GBQ
Consensus CDS ProjectCCDS25645.1
International Mouse Knockout Project StatusGrb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003535 VEGA Gene Model | MGI Sequence Detail 64553 C57BL/6J ±  kb
transcript OTTMUST00000007575 VEGA | MGI Sequence Detail 2683 Not Applicable 
polypeptide OTTMUSP00000003660 VEGA | MGI Sequence Detail 217 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(2) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000008224 growth factor receptor-bound protein 2
References
(Earliest) J:23345 Lowenstein EJ, et al., The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell. 1992 Aug 7;70(3):431-42
(Latest) J:206901 Findlay GM, et al., Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. Cell. 2013 Feb 28;152(5):1008-20
All references(130)
Other
accession IDs
MGD-MRK-10242, MGI:2143976

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory