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Grb2 Gene Detail
Summary
  • Symbol
    Grb2
  • Name
    growth factor receptor bound protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95805
    NCBI Gene: 14784
  • Gene Overview
    MyGene.info: GRB2
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115644045-115708597 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.91 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    241 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95805
protein coding gene Chr11:115644045-115708597 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019398
protein coding gene Chr11:119689746-119764087 (-)
A/J MGP_AJ_G0019367
protein coding gene Chr11:114465035-114534186 (-)
AKR/J MGP_AKRJ_G0019337
protein coding gene Chr11:117871370-117949341 (-)
BALB/cJ MGP_BALBcJ_G0019341
protein coding gene Chr11:114880107-114948501 (-)
C3H/HeJ MGP_C3HHeJ_G0019147
protein coding gene Chr11:118237403-118307206 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019791
protein coding gene Chr11:123343339-123419180 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017414
protein coding gene Chr11:111489787-111558655 (-)
CAST/EiJ MGP_CASTEiJ_G0018702
protein coding gene Chr11:119550692-119617158 (-)
CBA/J MGP_CBAJ_G0019119
protein coding gene Chr11:128233678-128318205 (-)
DBA/2J MGP_DBA2J_G0019230
protein coding gene Chr11:113896080-113961175 (-)
FVB/NJ MGP_FVBNJ_G0019222
protein coding gene Chr11:113381777-113448966 (-)
LP/J MGP_LPJ_G0019300
protein coding gene Chr11:120075342-120150503 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019255
protein coding gene Chr11:127366807-127439411 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019829
protein coding gene Chr11:118533105-118605904 (-)
PWK/PhJ MGP_PWKPhJ_G0018466
protein coding gene Chr11:115186254-115255935 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018259
protein coding gene Chr11:118281551-118350636 (-)
WSB/EiJ MGP_WSBEiJ_G0018754
protein coding gene Chr11:118495902-118569298 (-)



Homology
more
  • Human Ortholog
    GRB2, growth factor receptor bound protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GRB2, growth factor receptor bound protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2
  • Links
    NCBI Gene ID: 2885
    neXtProt AC: NX_P62993
    UniProt: P62993

  • Chr Location
    17q25.1; chr17:75318076-75405709 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1576
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: GRB2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 6 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a targeted null mutation lack expanded inner cell masses, show only a few endodermal cells, and die by embryonic day 7.5. Heterozygotes have defective T cell signaling and lack the cardiac hypertrophy response to pressure overload.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14784 NCBI Gene Model | MGI Sequence Detail 64553 C57BL/6J ±  kb
    transcript NM_008163 RefSeq | MGI Sequence Detail 2725 C57BL/6  
    polypeptide Q60631 UniProt | EBI | MGI Sequence Detail 217 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 27
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10242, MGI:2143976
    References
    more
    • Summaries
      All 169
      Developmental Gene Expression 12
      Gene Ontology 59
      Phenotypes 30
    • Earliest
      J:23345 Lowenstein EJ, et al., The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell. 1992 Aug 7;70(3):431-42
    • Latest
      J:272613 Koutelou E, et al., USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development. 2019 Feb 22;146(4)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/11/2019
    MGI 6.14
    The Jackson Laboratory