Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables several functions, including enzyme binding activity; ephrin receptor binding activity; and guanyl-nucleotide exchange factor adaptor activity. Involved in cell surface receptor signaling pathway and nervous system development. Acts upstream of or within several processes, including embryonic morphogenesis; fibroblast growth factor receptor signaling pathway; and positive regulation of actin filament polymerization. Located in several cellular components, including cell-cell junction; plasma membrane; and vesicle membrane. Part of COP9 signalosome. Is active in cell cortex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2).