About   Help   FAQ
Gnai2
Gene Detail
Symbol

Name
ID
Gnai2
guanine nucleotide binding protein (G protein), alpha inhibiting 2
MGI:95772
Synonyms
Galphai2, Gia, Gnai-2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
58.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr9:107614125-107635367 bp, - strand
From VEGA annotation of GRCm38

  21243 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GNAI2
Gene Tree: Gnai2

Human
homologs
GNAI2, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2771
neXtProt AC: NX_P04899

Human Synonyms: GIP, GNAI2B, H_LUCA15.1, H_LUCA16.1

Human Chr (Location): 3p21.31; chr3:50226688-50259354 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GNAI2

Mutations,
alleles, and
phenotypes
All mutations/alleles(55) : Gene trapped(44) Targeted(10) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice exhibit growth retardation, lethal ulcerative colitis, colon adenocarcinomas, granulocytosis, altered thymocyte maturation and function and enhanced production of pro-inflammatory cytokines, and may show alterations in leukocyte physiology and susceptibility to parasitic infection.
 
Human Diseases Modeled in Mice Using Gnai2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Gnai2 interacts with 201 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (24 records)
Data Summary: Results (251)    Tissues (139)    Images (67)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 229
RT-PCR 21
cDNA source data(469)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GNAI2 ; Xenbase gnai2 ; ZFIN gnai2a, gnai2b    NEW 
Molecular
reagents
All nucleic(480) Genomic(3) cDNA(472) Primer pair(3) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000050782 (Evidence)
Ensembl Gene Model ENSMUSG00000032562 (Evidence)
Entrez Gene 14678 (Evidence)
UniGene 196464
DFCI TC1573504, TC1576297, TC1587094, TC1775310
DoTS DT.101139342, DT.101381035, DT.102557701, DT.110630576, DT.87069923, DT.94397834, DT.97385830
NIA Mouse Gene Index U031319
Consensus CDS Project CCDS23502.1
International Mouse Phenotyping Consortium Status Gnai2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050782 VEGA Gene Model | MGI Sequence Detail 21243 C57BL/6J ±  kb
transcript OTTMUST00000128708 VEGA | MGI Sequence Detail 2215 Not Applicable 
polypeptide OTTMUSP00000069219 VEGA | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(4) UniProt(6)
Polymorphisms
RFLP(5) : SNPs within 2kb(209 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001408 G-protein alpha subunit, group I
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008086 guanine nucleotide-binding protein G(i) subunit alpha-2
References
(Earliest) J:8410 Sullivan KA, et al., Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91
(Latest) J:221651 Devanathan V, et al., Platelet Gi protein Galphai2 is an essential mediator of thrombo-inflammatory organ damage in mice. Proc Natl Acad Sci U S A. 2015 May 19;112(20):6491-6
All references(174)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-10075, MGD-MRK-10181, MGD-MRK-10184, MGI:2143377

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory