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Gnai2 Gene Detail
Summary
  • Symbol
    Gnai2
  • Name
    guanine nucleotide binding protein (G protein), alpha inhibiting 2
  • Synonyms
    Galphai2, Gia, Gnai-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95772
    NCBI Gene: 14678
  • Gene Overview
    MyGene.info: GNAI2
Location & Maps
more
  • Sequence Map
    Chr9:107614125-107635367 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21243 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 58.43 cM
  • Mapping Data
    23 experiments
Homology
more
  • Human Ortholog
    GNAI2, G protein subunit alpha i2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GNAI2, G protein subunit alpha i2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GIP, GNAI2B, H_LUCA15.1, H_LUCA16.1
  • Links
    NCBI Gene ID: 2771
    neXtProt AC: NX_P04899

  • Chr Location
    3p21.31; chr3:50226688-50259354 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55539
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: GNAI2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Gnai2 mouse models; 1 with human GNAI2 associations

Human Disease Mouse Models
       Inflammatory Bowel Disease 12; IBD12   OMIM: 612241 View 3 models
       Ventricular Tachycardia, Familial   OMIM: 192605
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    65 phenotypes from 5 alleles in 11 genetic backgrounds
    19 phenotypes from multigenic genotypes
    2 images
    94 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    55
  • Gene trapped
    44
  • Targeted
    10
  • Transgenic
    1
  • Incidental Mutations
Nullizygous mice exhibit growth retardation, lethal ulcerative colitis, colon adenocarcinomas, granulocytosis, altered thymocyte maturation and function and enhanced production of pro-inflammatory cytokines, and may show alterations in leukocyte physiology and susceptibility to parasitic infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050782 VEGA Gene Model | MGI Sequence Detail 21243 C57BL/6J ±  kb
transcript OTTMUST00000128924 VEGA | MGI Sequence Detail 1777 Not Applicable  
polypeptide OTTMUSP00000069326 VEGA | MGI Sequence Detail 355 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    206 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000008086 guanine nucleotide-binding protein G(i) subunit alpha-2
  • InterPro Domains
    IPR001408 G-protein alpha subunit, group I
    IPR011025 G protein alpha subunit, helical insertion
    IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 480
    Genomic 3
    cDNA 472
    Primer pair 3
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10075, MGD-MRK-10181, MGD-MRK-10184, MGI:2143377
References
more
  • Summaries
    All 175
    Developmental Gene Expression 24
    Diseases 3
    Gene Ontology 12
    Phenotypes 94
  • Earliest
    J:8410 Sullivan KA, et al., Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91
  • Latest
    J:226437 Hillgruber C, et al., Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia. J Exp Med. 2015 Jul 27;212(8):1255-66

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory