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Gnai2
Gene Detail
 Symbol
Name
ID
Gnai2
guanine nucleotide binding protein (G protein), alpha inhibiting 2
MGI:95772
Synonyms Galphai2, Gia, Gnai-2
Feature Type protein coding gene
Genetic Map
Chromosome 9
58.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr9:107614138-107635342 bp, - strand
From NCBI annotation of GRCm38

  21205 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gnai2

Human
homologs
Human Homolog GNAI2, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
NCBI Gene ID 2771
neXtProt AC  NX_P04899
Human Synonyms  GIP, GNAI2B, H_LUCA15.1, H_LUCA16.1
Human Chr (Location)  3p21.31; chr3:50226688-50259354 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GNAI2
Mutations,
alleles, and
phenotypes
All mutations/alleles(52) : Gene trapped(44) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice exhibit growth retardation, lethal ulcerative colitis, colon adenocarcinomas, granulocytosis, altered thymocyte maturation and function and enhanced production of pro-inflammatory cytokines, and may show alterations in leukocyte physiology and susceptibility to parasitic infection.
 
Human Diseases Modeled Using Mouse Gnai2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Gnai2 interacts with 201 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process activation of MAPKK activity, adenosine receptor signaling pathway, ...
Component centrosome, cytoplasm, ...
Function G-protein beta/gamma-subunit complex binding, G-protein coupled receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (250)    Tissues (138)    Images (67)
Theiler Stages: 1, 2, 3, 4, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 229
RT-PCR 21
cDNA source data(469)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(480) Genomic(3) cDNA(472) Primer pair(3) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000032562 (Evidence)
Entrez Gene14678 (Evidence)
UniGene196464
DFCITC1573504, TC1576297, TC1587094, TC1775310
DoTSDT.101139342, DT.101381035, DT.102557701, DT.110630576, DT.87069923, DT.94397834, DT.97385830
NIA Mouse Gene IndexU031319
Consensus CDS ProjectCCDS23502.1
International Mouse Knockout Project StatusGnai2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14678 NCBI Gene Model | MGI Sequence Detail 21205 C57BL/6J ±  kb
transcript NM_008138 RefSeq | MGI Sequence Detail 2177 C57BL/6 
polypeptide P08752 UniProt | EBI | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(4) UniProt(3)
Polymorphisms RFLP(5) : SNPs within 2kb(209 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001408 G-protein alpha subunit, group I
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008086 guanine nucleotide-binding protein G(i) subunit alpha-2
Graphical View of Protein Domain Structure
References (Earliest) J:8410 Sullivan KA, et al., Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91
(Latest) J:209809 Diehl SA, et al., G proteins Galphai1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization. Infect Immun. 2014 Feb;82(2):773-82
All references(167)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-10075, MGD-MRK-10181, MGD-MRK-10184, MGI:2143377

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory