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Slc2a4 Gene Detail
Summary
  • Symbol
    Slc2a4
  • Name
    solute carrier family 2 (facilitated glucose transporter), member 4
  • Synonyms
    Glut4, Glut-4, twgy
  • Feature Type
    protein coding gene
  • IDs
    MGI:95758
    NCBI Gene: 20528
  • Gene Overview
    MyGene.info: SLC2A4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69942539-69948188 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.93 cM, cytoband C-E1
  • Mapping Data
    11 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95758
protein coding gene Chr11:69942286-69948217 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018571
protein coding gene Chr11:70431076-70436713 (-)
A/J MGP_AJ_G0018539
protein coding gene Chr11:67764217-67769853 (-)
AKR/J MGP_AKRJ_G0018508
protein coding gene Chr11:69786550-69792184 (-)
BALB/cJ MGP_BALBcJ_G0018511
protein coding gene Chr11:68096183-68101819 (-)
C3H/HeJ MGP_C3HHeJ_G0018324
protein coding gene Chr11:69823901-69829537 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018962
protein coding gene Chr11:72557771-72563407 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016607
protein coding gene Chr11:64692939-64698577 (-)
CAST/EiJ MGP_CASTEiJ_G0017879
protein coding gene Chr11:70066712-70072358 (-)
CBA/J MGP_CBAJ_G0018296
protein coding gene Chr11:75810322-75816217 (-)
DBA/2J MGP_DBA2J_G0018406
protein coding gene Chr11:67350244-67355892 (-)
FVB/NJ MGP_FVBNJ_G0018396
protein coding gene Chr11:66995831-67001464 (-)
LP/J MGP_LPJ_G0018476
protein coding gene Chr11:71014090-71019727 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018419
protein coding gene Chr11:76400830-76406466 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019004
protein coding gene Chr11:70059747-70065383 (-)
PWK/PhJ MGP_PWKPhJ_G0017653
protein coding gene Chr11:68002344-68008065 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017443
protein coding gene Chr11:69875742-69881383 (-)
WSB/EiJ MGP_WSBEiJ_G0017933
protein coding gene Chr11:69723847-69729490 (-)



Homology
more
  • Human Ortholog
    SLC2A4, solute carrier family 2 member 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC2A4, solute carrier family 2 member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLUT4
  • Links
    NCBI Gene ID: 6517
    neXtProt AC: NX_P14672
    UniProt: P14672

  • Chr Location
    17p13.1; chr17:7281735-7288048 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Slc2a4 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 3 alleles in 11 genetic backgrounds
    5 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes impaired glucose metabolism in skeletal muscle and adipose tissue. Mice homozygous for a knock-out allele show premature death associated with cardiac hypertrophy, growth retardation, insulin resistance, reduced adipose tissue deposits, and muscle fatigue.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018566 Ensembl Gene Model | MGI Sequence Detail 5650 C57BL/6J ±  kb
    transcript ENSMUST00000018710 Ensembl | MGI Sequence Detail 2524 Not Applicable  
    polypeptide ENSMUSP00000018710 Ensembl | MGI Sequence Detail 509 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000015066 solute carrier family 2, facilitated glucose transporter member 4
    • InterPro Domains
      IPR002441 Glucose transporter, type 4 (GLUT4)
      IPR005828 Major facilitator, sugar transporter-like
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
      IPR003663 Sugar/inositol transporter
      IPR005829 Sugar transporter, conserved site
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 2
      cDNA 52
      Primer pair 7
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10158, MGD-MRK-10162, MGI:3588496
    References
    more
    • Summaries
      All 309
      Developmental Gene Expression 27
      Diseases 1
      Gene Ontology 36
      Phenotypes 67
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:267065 Shin BC, et al., Neural Deletion of Glucose Transporter Isoform 3 Creates Distinct Postnatal and Adult Neurobehavioral Phenotypes. J Neurosci. 2018 Oct 31;38(44):9579-9599

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory