Slc2a4
Gene Detail

Symbol Name ID

Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 MGI:95758

STS

D11Mit15

Synonyms

Glut4, Glut-4

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.93 cM, cytoband C-E1
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr11:69942539-69948188 bp, - strand From VEGA annotation of GRCm38   5650 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74381  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Slc2a4

Human homologs

Human Homolog		SLC2A4, solute carrier family 2 (facilitated glucose transporter), member 4
NCBI Gene ID		6517
neXtProt AC		NX_P14672
Human Synonyms		GLUT4
Human Chr (Location)		17p13; chr17:7185054-7191367 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC2A4

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous inactivation of this gene causes impaired glucose metabolism in skeletal muscle and adipose tissue. Mice homozygous for a knock-out allele show premature death associated with cardiac hypertrophy, growth retardation, insulin resistance, reduced adipose tissue deposits, and muscle fatigue.

 
Human Diseases Modeled Using Mouse Slc2a4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (55 annotations)

Process	amylopectin biosynthetic process, brown fat cell differentiation, ...
Component	clathrin-coated vesicle, coated pit, ...
Function	D-glucose transmembrane transporter activity, glucose transmembrane transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (206)    Tissues (150)    Images (6)
Theiler Stages: 11, 13, 15, 17, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	95
Northern blot	16
RT-PCR	95

cDNA source data(48)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(62) Genomic(2) cDNA(50) Primer pair(7) Other(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006028 (Evidence)
Ensembl Gene Model	ENSMUSG00000018566 (Evidence)
Entrez Gene	20528 (Evidence)
UniGene	10661
DFCI	TC1576122
DoTS	DT.532441, DT.91335589, DT.91411894
NIA Mouse Gene Index	U158646
Consensus CDS Project	CCDS36201.1
International Mouse Knockout Project Status	Slc2a4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006028	VEGA Gene Model | MGI Sequence Detail	5650	C57BL/6J
transcript	OTTMUST00000013537	VEGA | MGI Sequence Detail	2524	Not Applicable
polypeptide	OTTMUSP00000006275	VEGA | MGI Sequence Detail	509	Not Applicable

All sequences(55) RefSeq(2) UniProt(6)

Polymorphisms

PCR(3) : SNPs(38 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005828	General substrate transporter
InterPro	IPR002441	Glucose transporter, type 4 (GLUT4)
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
InterPro	IPR003663	Sugar/inositol transporter
InterPro	IPR005829	Sugar transporter, conserved site
Protein Ontology	PR:000015066	solute carrier family 2, facilitated glucose transporter member 4

References

(Earliest) J:4901 Fan YS, et al., Assignment of genes encoding three human glucose transporter/transporter-like proteins (GLUT4, GLUT5 and GLUT6) to chromosomes 17, 1 and 5 respectively. Cytogenet Cell Genet. 1989;51:997
(Latest) J:192039 Waller AP, et al., GLUT12 functions as a basal and insulin-independent glucose transporter in the heart. Biochim Biophys Acta. 2013 Jan;1832(1):121-7
All references(190)

Other accession IDs

MGD-MRK-10158, MGD-MRK-10162