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Slc2a4
Gene Detail
Symbol

Name
ID
Slc2a4
solute carrier family 2 (facilitated glucose transporter), member 4
MGI:95758
STS
Synonyms
Glut4, Glut-4
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.93 cM, cytoband C-E1
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr11:69942539-69948188 bp, - strand
From VEGA annotation of GRCm38

  5650 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74381  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SLC2A4
Gene Tree: Slc2a4

Human
homologs
SLC2A4, solute carrier family 2 (facilitated glucose transporter), member 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6517
neXtProt AC: NX_P14672

Human Synonyms: GLUT4

Human Chr (Location): 17p13; chr17:7281735-7288048 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Slc2a4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene causes impaired glucose metabolism in skeletal muscle and adipose tissue. Mice homozygous for a knock-out allele show premature death associated with cardiac hypertrophy, growth retardation, insulin resistance, reduced adipose tissue deposits, and muscle fatigue.
 
Human Diseases Modeled in Mice Using Slc2a4 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Slc2a4 interacts with 175 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (19 records)
Data Summary: Results (206)    Tissues (150)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 95
Northern blot 16
RT-PCR 95
cDNA source data(49)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(63) Genomic(2) cDNA(51) Primer pair(7) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006028 (Evidence)
Ensembl Gene Model ENSMUSG00000018566 (Evidence)
Entrez Gene 20528 (Evidence)
UniGene 10661
DFCI TC1576122
DoTS DT.532441, DT.91335589, DT.91411894
NIA Mouse Gene Index U158646
Consensus CDS Project CCDS36201.1
International Mouse Phenotyping Consortium Status Slc2a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006028 VEGA Gene Model | MGI Sequence Detail 5650 C57BL/6J ±  kb
transcript OTTMUST00000013537 VEGA | MGI Sequence Detail 2524 Not Applicable 
polypeptide OTTMUSP00000006275 VEGA | MGI Sequence Detail 509 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(18) UniProt(7)
Polymorphisms
PCR(3) : SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002441 Glucose transporter, type 4 (GLUT4)
InterPro IPR005828 Major facilitator, sugar transporter-like
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR003663 Sugar/inositol transporter
InterPro IPR005829 Sugar transporter, conserved site
Protein Ontology PR:000015066 solute carrier family 2, facilitated glucose transporter member 4
References
(Earliest) J:4901 Fan YS, et al., Assignment of genes encoding three human glucose transporter/transporter-like proteins (GLUT4, GLUT5 and GLUT6) to chromosomes 17, 1 and 5 respectively. Cytogenet Cell Genet. 1989;51:997
(Latest) J:222913 Lorenzo DN, et al., Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic beta cell insufficiency. J Clin Invest. 2015 Aug 3;125(8):3087-3102
All references(202)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10158, MGD-MRK-10162

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory