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Slc2a4
Gene Detail
 Symbol
Name
ID
Slc2a4
solute carrier family 2 (facilitated glucose transporter), member 4
MGI:95758
STS D11Mit15
Synonyms Glut4, Glut-4
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.93 cM, cytoband C-E1
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr11:69942539-69948188 bp, - strand
From VEGA annotation of GRCm38

  5650 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74381  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Slc2a4

Human
homologs
Human Homolog SLC2A4, solute carrier family 2 (facilitated glucose transporter), member 4
NCBI Gene ID 6517
neXtProt AC  NX_P14672
Human Synonyms  GLUT4
Human Chr (Location)  17p13; chr17:7281735-7288048 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC2A4
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene causes impaired glucose metabolism in skeletal muscle and adipose tissue. Mice homozygous for a knock-out allele show premature death associated with cardiac hypertrophy, growth retardation, insulin resistance, reduced adipose tissue deposits, and muscle fatigue.
 
Human Diseases Modeled Using Mouse Slc2a4 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process amylopectin biosynthetic process, brown fat cell differentiation, ...
Component cell surface, clathrin-coated vesicle, ...
Function D-glucose transmembrane transporter activity, glucose transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (206)    Tissues (150)    Images (6)
Theiler Stages: 11, 13, 15, 17, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 95
Northern blot 16
RT-PCR 95
cDNA source data(49)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(63) Genomic(2) cDNA(51) Primer pair(7) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006028 (Evidence)
Ensembl Gene ModelENSMUSG00000018566 (Evidence)
Entrez Gene20528 (Evidence)
UniGene10661
DFCITC1576122
DoTSDT.532441, DT.91335589, DT.91411894
NIA Mouse Gene IndexU158646
Consensus CDS ProjectCCDS36201.1
International Mouse Knockout Project StatusSlc2a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006028 VEGA Gene Model | MGI Sequence Detail 5650 C57BL/6J ±  kb
transcript OTTMUST00000013537 VEGA | MGI Sequence Detail 2524 Not Applicable 
polypeptide OTTMUSP00000006275 VEGA | MGI Sequence Detail 509 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(14) UniProt(6)
Polymorphisms PCR(3) : SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR002441 Glucose transporter, type 4 (GLUT4)
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR003663 Sugar/inositol transporter
InterPro IPR005829 Sugar transporter, conserved site
Protein Ontology PR:000015066 solute carrier family 2, facilitated glucose transporter member 4
References (Earliest) J:4901 Fan YS, et al., Assignment of genes encoding three human glucose transporter/transporter-like proteins (GLUT4, GLUT5 and GLUT6) to chromosomes 17, 1 and 5 respectively. Cytogenet Cell Genet. 1989;51:997
(Latest) J:209030 Guzman J, et al., Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy. Diabetes. 2014 Feb;63(2):701-14
All references(197)
Other
accession IDs
MGD-MRK-10158, MGD-MRK-10162

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory