About   Help   FAQ
Glud1 Gene Detail
Summary
  • Symbol
    Glud1
  • Name
    glutamate dehydrogenase 1
  • Synonyms
    Gdh-X, Glud
  • Feature Type
    protein coding gene
  • IDs
    MGI:95753
    NCBI Gene: 14661
  • Gene Overview
    MyGene.info: GLUD1
Location & Maps
more
  • Sequence Map
    Chr14:34310727-34345144 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34418 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 20.80 cM
  • Mapping Data
    19 experiments
Homology
more
  • Human Ortholog
    GLUD1, glutamate dehydrogenase 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    GLUD1, glutamate dehydrogenase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GDH, GDH1, GLUD
  • Links
    NCBI Gene ID: 2746
    neXtProt AC: NX_P00367

  • Chr Location
    10q23.3; chr10:87050202-87095019 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GLUD1 associations

Human Disease Mouse Models
       Hyperinsulinemic Hypoglycemia, Familial, 6; HHF6   OMIM: 606762
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    2 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    50
  • Gene trapped
    47
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a conditionally allele activated in beta cells exhibit reduced glucose-stimulated insulin secretion and disorganization of pancreatic islets.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030736 VEGA Gene Model | MGI Sequence Detail 34418 C57BL/6J ±  kb
transcript OTTMUST00000076096 VEGA | MGI Sequence Detail 3269 Not Applicable  
polypeptide OTTMUSP00000039999 VEGA | MGI Sequence Detail 558 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    224 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008056 glutamate dehydrogenase 1, mitochondrial
  • EC
  • InterPro Domains
    IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase
    IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal
    IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain
    IPR016040 NAD(P)-binding domain
Molecular
Reagents
less
  • All nucleic 18
    Genomic 1
    cDNA 15
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10046, MGD-MRK-10136, MGD-MRK-10139, MGI:2145599
References
more
  • Summaries
    All 62
    Developmental Gene Expression 4
    Gene Ontology 12
    Phenotypes 11
  • Earliest
    J:8729 Banner C, et al., Isolation of a human brain cDNA for glutamate dehydrogenase. J Neurochem. 1987 Jul;49(1):246-52
  • Latest
    J:205028 Karaca M, et al., Development of Mice with Brain-Specific Deletion of Floxed Glud1 (Glutamate Dehydrogenase 1) Using Cre Recombinase Driven by the Nestin Promoter. Neurochem Res. 2013 Apr 18;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/15/2016
MGI 6.04
The Jackson Laboratory