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Glud1 Gene Detail
Summary
  • Symbol
    Glud1
  • Name
    glutamate dehydrogenase 1
  • Synonyms
    Gdh-X, Glud
  • Feature Type
    protein coding gene
  • IDs
    MGI:95753
    NCBI Gene: 14661
  • Gene Overview
    MyGene.info: GLUD1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:34310727-34345144 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34418 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 20.80 cM
  • Mapping Data
    19 experiments
Homology
more
  • Human Ortholog
    GLUD1, glutamate dehydrogenase 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    GLUD1, glutamate dehydrogenase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GDH, GDH1, GLUD
  • Links
    NCBI Gene ID: 2746
    neXtProt AC: NX_P00367
    UniProt: P00367

  • Chr Location
    10q23.2; chr10:87050202-87095047 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human GLUD1 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    2 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditionally allele activated in beta cells exhibit reduced glucose-stimulated insulin secretion and disorganization of pancreatic islets.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030736 VEGA Gene Model | MGI Sequence Detail 34418 C57BL/6J ±  kb
    transcript OTTMUST00000076096 VEGA | MGI Sequence Detail 3269 Not Applicable  
    polypeptide OTTMUSP00000039999 VEGA | MGI Sequence Detail 558 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      224 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008056 glutamate dehydrogenase 1, mitochondrial
    • EC
    • InterPro Domains
      IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase
      IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal
      IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain
      IPR033524 Leu/Phe/Val dehydrogenases active site
      IPR033922 NAD(P) binding domain of glutamate dehydrogenase
      IPR036291 NAD(P)-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 15
      Primer pair 1
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10046, MGD-MRK-10136, MGD-MRK-10139, MGI:2145599
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 13
      Phenotypes 15
    • Earliest
      J:8729 Banner C, et al., Isolation of a human brain cDNA for glutamate dehydrogenase. J Neurochem. 1987 Jul;49(1):246-52
    • Latest
      J:258277 Andersson LE, et al., Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase. Diabetes. 2018 Mar;67(3):372-384

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory