Glud1
Gene Detail

Symbol Name ID

Glud1 glutamate dehydrogenase 1 MGI:95753

Synonyms

Gdh-X, Glud

Feature Type

protein coding gene

Genetic Map

Chromosome 14

20.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)

Sequence Map

Chr14:34310727-34345144 bp, + strand From VEGA annotation of GRCm38   34418 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55885  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: glutamate dehydrogenase
Gene Tree: Glud1

Human homologs

Human Homolog		GLUD1, glutamate dehydrogenase 1
NCBI Gene ID		2746
neXtProt AC		NX_P00367
Human Synonyms		GDH, GDH1, GLUD
Human Chr (Location)		10q23.3; chr10:88809959-88854776 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GLUD1

Alleles and phenotypes

All alleles(50) : Targeted(3) Gene trapped(47)
 

Mice homozygous for a conditionally allele activated in beta cells exhibit reduced glucose-stimulated insulin secretion and disorganization of pancreatic islets.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	cellular amino acid metabolic process, glutamate biosynthetic process, ...
Component	cytoplasm, mitochondrial inner membrane, ...
Function	ADP binding, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (122)    Tissues (122)    Images (22)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	122

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(1) cDNA(15) Primer pair(1) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000030736 (Evidence)
Ensembl Gene Model	ENSMUSG00000021794 (Evidence)
Entrez Gene	14661 (Evidence)
DFCI	TC1592348, TC1646582
DoTS	DT.101381154, DT.537323
EC	1.4.1.3
Consensus CDS Project	CCDS26935.1
International Mouse Knockout Project Status	Glud1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030736	VEGA Gene Model | MGI Sequence Detail	34418	C57BL/6J
transcript	OTTMUST00000076096	VEGA | MGI Sequence Detail	3269	Not Applicable
polypeptide	OTTMUSP00000039999	VEGA | MGI Sequence Detail	558	Not Applicable

All sequences(48) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(9) : SNPs(169 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006095	Glutamate/phenylalanine/leucine/valine dehydrogenase
InterPro	IPR006096	Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal
InterPro	IPR006097	Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000008056	glutamate dehydrogenase 1, mitochondrial

References

(Earliest) J:8729 Banner C, et al., Isolation of a human brain cDNA for glutamate dehydrogenase. J Neurochem. 1987 Jul;49(1):246-52
(Latest) J:190560 Frigerio F, et al., Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission. J Neurochem. 2012 Nov;123(3):342-8
All references(59)

Other accession IDs

MGD-MRK-10046, MGD-MRK-10136, MGD-MRK-10139, MGI:2145599