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Glud1
Gene Detail
Symbol

Name
ID
Glud1
glutamate dehydrogenase 1
MGI:95753
Synonyms
Gdh-X, Glud
Feature Type
protein coding gene
Genetic Map
Chromosome 14
20.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr14:34310727-34345144 bp, + strand
From VEGA annotation of GRCm38

  34418 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55885  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 2 zebrafish

Protein SuperFamily: glutamate dehydrogenase
Gene Tree: Glud1

Human
homologs
Human Homolog GLUD1, glutamate dehydrogenase 1
NCBI Gene ID 2746
neXtProt AC  NX_P00367
Human Synonyms  GDH, GDH1, GLUD
Human Chr (Location)  10q23.3; chr10:87050202-87095019 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GLUD1
Mutations,
alleles, and
phenotypes
All mutations/alleles(50) : Gene trapped(47) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a conditionally allele activated in beta cells exhibit reduced glucose-stimulated insulin secretion and disorganization of pancreatic islets.
 
Phenotype Images(2)
Interactions
Glud1 interacts with 259 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cellular amino acid metabolic process, glutamate biosynthetic process, ...
Component cytoplasm, mitochondrial inner membrane, ...
Function ADP binding, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (145)    Tissues (145)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 145
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(15) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030736 (Evidence)
Ensembl Gene ModelENSMUSG00000021794 (Evidence)
Entrez Gene14661 (Evidence)
DFCITC1592348, TC1646582
DoTSDT.101381154, DT.537323
EC1.4.1.3
Consensus CDS ProjectCCDS26935.1
International Mouse Knockout Project StatusGlud1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030736 VEGA Gene Model | MGI Sequence Detail 34418 C57BL/6J ±  kb
transcript OTTMUST00000076096 VEGA | MGI Sequence Detail 3269 Not Applicable 
polypeptide OTTMUSP00000039999 VEGA | MGI Sequence Detail 558 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(9) : SNPs within 2kb(225 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase
InterPro IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal
InterPro IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000008056 glutamate dehydrogenase 1, mitochondrial
References
(Earliest) J:8729 Banner C, et al., Isolation of a human brain cDNA for glutamate dehydrogenase. J Neurochem. 1987 Jul;49(1):246-52
(Latest) J:205028 Karaca M, et al., Development of Mice with Brain-Specific Deletion of Floxed Glud1 (Glutamate Dehydrogenase 1) Using Cre Recombinase Driven by the Nestin Promoter. Neurochem Res. 2013 Apr 18;
All references(66)
Other
accession IDs
MGD-MRK-10046, MGD-MRK-10136, MGD-MRK-10139, MGI:2145599

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory