Sequence Detail

ID/Version

P26443 Q8C273 (UniProt | EBI)

Last sequence update: 1992-08-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Glutamate dehydrogenase 1, mitochondrial; Short=GDH 1; EC=1.4.1.3 {ECO:0000269|PubMed:20670938};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 558 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Glud1	glutamate dehydrogenase 1	40	101	5	46

Sequence references in MGI

J:11265 Tzimagiorgis G, et al., Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA. Biochim Biophys Acta. 1991 Jun 13;1089(2):250-3
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:129427 Haigis MC, et al., SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 2006 Sep 8;126(5):941-54
J:166803 Li C, et al., Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. J Biol Chem. 2010 Oct 8;285(41):31806-18
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6
J:198927 Csibi A, et al., The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 2013 May 9;153(4):840-54
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89