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Glo1
Gene Detail
Symbol

Name
ID
Glo1
glyoxalase 1
MGI:95742
Synonyms
0610009E22Rik, 1110008E19Rik, 2510049H23Rik, Glo-1, Glo-1r, Glo1-r, Glo-1s, Glo1-s, Qglo
Feature Type
protein coding gene
Genetic Map
Chromosome 17
15.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(64)
Sequence Map
Chr17:30592866-30612659 bp, - strand
From Ensembl annotation of GRCm38

  19794 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4880  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GLO1
Gene Tree: Glo1

Human
homologs
GLO1, glyoxalase I
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2739
neXtProt AC: NX_Q04760

Human Synonyms: GLOD1, GLYI, HEL-S-74

Human Chr (Location): 6p21.3-p21.1; chr6:38675925-38703176 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(74) : Gene trapped(70) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
This locus controls electrophoretic mobility and activity level of erythrocyte GLO1. The a allele produces a fast migrating band seen in AKR, CBA/H and C57BL/6; the b allele, a slow band, in MA/MyJ. At least 6 different activity-determining alleles, designated ra through rf, are found among strains.
 
Interactions
Glo1 interacts with 181 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process carbohydrate metabolic process, glutathione metabolic process, ...
Component extracellular exosome
Function lactoylglutathione lyase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (141)    Tissues (124)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 141
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase glo1 ; ZFIN glo1    NEW 
Molecular
reagents
All nucleic(18) cDNA(17) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000024026 (Evidence)
Entrez Gene 109801 (Evidence)
DFCI TC1573552, TC1591628, TC1695801, TC1697568
DoTS DT.101387967, DT.101713383, DT.110555530, DT.495459
NIA Mouse Gene Index U001655, U037639
EC 4.4.1.5
PDB 4KYH, 4KYK, 4OPN, 2ZA0, 4PV5
Consensus CDS Project CCDS28600.1
International Mouse Phenotyping Consortium Status Glo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024026 Ensembl Gene Model | MGI Sequence Detail 19794 C57BL/6J ±  kb
transcript ENSMUST00000024823 Ensembl | MGI Sequence Detail 1935 Not Applicable 
polypeptide ENSMUSP00000024823 Ensembl | MGI Sequence Detail 184 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
InterPro IPR004361 Glyoxalase I
InterPro IPR018146 Glyoxalase I, conserved site
Protein Ontology PR:000008038 lactoylglutathione lyase
References
(Earliest) J:5879 Meo T, et al., Glyoxalase I polymorphism in the mouse: a new genetic marker linked to H-2. Science. 1977 Oct 21;198(4314):311-3
(Latest) J:217461 Yang G, et al., An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Neuron. 2014 Nov 19;84(4):723-39
All references(84)
Other
accession IDs
MGD-MRK-10120, MGD-MRK-10121, MGD-MRK-10122, MGD-MRK-10124, MGD-MRK-10125, MGD-MRK-10126, MGD-MRK-13737, MGI:1913383, MGI:1917563, MGI:1918922, MGI:2147081, MGI:95743, MGI:95744

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory