About   Help   FAQ
Glo1
Gene Detail
 Symbol
Name
ID
Glo1
glyoxalase 1
MGI:95742
Synonyms 0610009E22Rik, 1110008E19Rik, 2510049H23Rik, Glo-1, Glo-1r, Glo1-r, Glo-1s, Glo1-s, Qglo
Feature Type protein coding gene
Genetic Map
Chromosome 17
15.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(63)
Sequence Map
Chr17:30592866-30612659 bp, - strand
From Ensembl annotation of GRCm38

  19794 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4880  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Glo1

Human
homologs
Human Homolog GLO1, glyoxalase I
NCBI Gene ID 2739
neXtProt AC  NX_Q04760
Human Synonyms  GLOD1, GLYI, HEL-S-74
Human Chr (Location)  6p21.3-p21.1; chr6:38675925-38703176 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(74) : Gene trapped(70) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
This locus controls electrophoretic mobility and activity level of erythrocyte GLO1. The a allele produces a fast migrating band seen in AKR, CBA/H and C57BL/6; the b allele, a slow band, in MA/MyJ. At least 6 different activity-determining alleles, designated ra through rf, are found among strains.
 
Interactions
Glo1 interacts with 181 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process carbohydrate metabolic process, glutathione metabolic process, ...
Component extracellular vesicular exosome
Function lactoylglutathione lyase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (141)    Tissues (124)    Images (17)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 141
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(17) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000024026 (Evidence)
Entrez Gene109801 (Evidence)
DFCITC1573552, TC1591628, TC1695801, TC1697568
DoTSDT.101387967, DT.101713383, DT.110555530, DT.495459
NIA Mouse Gene IndexU001655, U037639
EC4.4.1.5
PDB4KYH, 4KYK, 2ZA0
Consensus CDS ProjectCCDS28600.1
International Mouse Knockout Project StatusGlo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024026 Ensembl Gene Model | MGI Sequence Detail 19794 C57BL/6J ±  kb
transcript ENSMUST00000167624 Ensembl | MGI Sequence Detail 895 Not Applicable 
polypeptide ENSMUSP00000126586 Ensembl | MGI Sequence Detail 184 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
InterPro IPR004361 Glyoxalase I
InterPro IPR018146 Glyoxalase I, conserved site
Protein Ontology PR:000008038 lactoylglutathione lyase
References (Earliest) J:5879 Meo T, et al., Glyoxalase I polymorphism in the mouse: a new genetic marker linked to H-2. Science. 1977 Oct 21;198(4314):311-3
(Latest) J:208917 Giacco F, et al., Knockdown of glyoxalase 1 mimics diabetic nephropathy in nondiabetic mice. Diabetes. 2014 Jan;63(1):291-9
All references(87)
Other
accession IDs
MGD-MRK-10120, MGD-MRK-10121, MGD-MRK-10122, MGD-MRK-10124, MGD-MRK-10125, MGD-MRK-10126, MGD-MRK-13737, MGI:1913383, MGI:1917563, MGI:1918922, MGI:2147081, MGI:95743, MGI:95744

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory