Glo1
Gene Detail

Symbol Name ID

Glo1 glyoxalase 1 MGI:95742

Synonyms

0610009E22Rik, 1110008E19Rik, 2510049H23Rik, Glo-1, Glo-1r, Glo1-r, Glo-1s, Glo1-s, Qglo

Feature Type

protein coding gene

Genetic Map

Chromosome 17

15.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(63)

Sequence Map

Chr17:30592866-30612659 bp, - strand From Ensembl annotation of GRCm38   19794 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4880  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Glo1

Human homologs

Human Homolog		GLO1, glyoxalase I
NCBI Gene ID		2739
neXtProt AC		NX_Q04760
Human Synonyms		GLOD1, GLYI
Human Chr (Location)		6p21.3-p21.1; chr6:38643701-38670952 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(74) : Targeted(4) Gene trapped(70)
 

This locus controls electrophoretic mobility and activity level of erythrocyte GLO1. The a allele produces a fast migrating band seen in AKR, CBA/H and C57BL/6; the b allele, a slow band, in MA/MyJ. At least 6 different activity-determining alleles, designated ra through rf, are found among strains.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	carbohydrate metabolic process, glutathione metabolic process, ...
Function	lactoylglutathione lyase activity, lyase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (141)    Tissues (124)    Images (17)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	141

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(17) Other(1)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000024026 (Evidence)
Entrez Gene	109801 (Evidence)
DFCI	TC1573552, TC1591628, TC1695801, TC1697568
DoTS	DT.101387967, DT.101713383, DT.110555530, DT.495459
NIA Mouse Gene Index	U001655, U037639
EC	4.4.1.5
PDB	2ZA0
Consensus CDS Project	CCDS28600.1
International Mouse Knockout Project Status	Glo1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024026	Ensembl Gene Model | MGI Sequence Detail	19794	C57BL/6J
transcript	ENSMUST00000024823	Ensembl | MGI Sequence Detail	1935	Not Applicable
polypeptide	ENSMUSP00000024823	Ensembl | MGI Sequence Detail	184	Not Applicable

All sequences(44) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(88 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004360	Glyoxalase/fosfomycin resistance/dioxygenase domain
InterPro	IPR004361	Glyoxalase I
InterPro	IPR018146	Glyoxalase I, conserved site
Protein Ontology	PR:000008038	lactoylglutathione lyase

References

(Earliest) J:5879 Meo T, et al., Glyoxalase I polymorphism in the mouse: a new genetic marker linked to H-2. Science. 1977 Oct 21;198(4314):311-3
(Latest) J:178902 Belanger M, et al., Role of the glyoxalase system in astrocyte-mediated neuroprotection. J Neurosci. 2011 Dec 14;31(50):18338-52
All references(84)

Other accession IDs

MGD-MRK-10120, MGD-MRK-10121, MGD-MRK-10122, MGD-MRK-10124, MGD-MRK-10125, MGD-MRK-10126, MGD-MRK-13737, MGI:1913383, MGI:1917563, MGI:1918922, MGI:2147081, MGI:95743, MGI:95744