Gdf6
Gene Detail

Symbol Name ID

Gdf6 growth differentiation factor 6 MGI:95689

Synonyms

BMP13

Feature Type

protein coding gene

Genetic Map

Chromosome 4

4.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:9844372-9862345 bp, + strand From VEGA annotation of GRCm38   17974 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee    (Mammalian Orthology)
Comparative Map (Mouse/Human Gdf6 ± 2 cM)

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Gdf6

Human ortholog

GDF6 growth differentiation factor 6 NCBI Gene ID 392255
Human Synonyms: BMP13, CDMP2, KFM, KFS, KFS1, KFSL, MCOP4, MCOPCB6, SCDO4, SGM1
Human Chr8:97154558-97173020 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human GDF6 (3)

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice show multiple joint and skeletal patterning defects affecting the extremities, inner ear, and skull.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	activin receptor signaling pathway, BMP signaling pathway, ...
Component	extracellular region, extracellular space
Function	cytokine activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (111)    Tissues (35)    Images (32)
Theiler Stages: 17, 19, 21, 22, 23, 24, 25, 26

Assay Type	Results
RNA in situ	107
RT-PCR	4

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(1) cDNA(9) Primer pair(3)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000004534 (Evidence)
Ensembl Gene Model	ENSMUSG00000051279 (Evidence)
Entrez Gene	242316 (Evidence)
UniGene	302555
DFCI	TC1587838
DoTS	DT.91335784
NIA Mouse Gene Index	U050612
Consensus CDS Project	CCDS17960.1
International Mouse Knockout Project Status	Gdf6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004534	VEGA Gene Model | MGI Sequence Detail	17974	C57BL/6J
transcript	OTTMUST00000010266	VEGA | MGI Sequence Detail	3532	Not Applicable
polypeptide	OTTMUSP00000004875	VEGA | MGI Sequence Detail	454	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(54 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002405	Inhibin, alpha subunit
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000007924	growth/differentiation factor 6

References

(Earliest) J:17582 Storm EE, et al., Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily [see comments]. Nature. 1994 Apr 14;368(6472):639-43
(Latest) J:187424 Clendenning DE, et al., The BMP ligand Gdf6 prevents differentiation of coronal suture mesenchyme in early cranial development. PLoS One. 2012;7(5):e36789
All references(38)

Other accession IDs

MGD-MRK-10042