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Gdf5
Gene Detail
 Symbol
Name
ID
Gdf5
growth differentiation factor 5
MGI:95688
Synonyms bp, brp, cartilage-derived morphogenetic protein-1, CDMP-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
77.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr2:155941023-155945367 bp, - strand
From VEGA annotation of GRCm38

  4345 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:468  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Gdf5

Human
homologs
Human Homolog GDF5, growth differentiation factor 5
NCBI Gene ID 8200
neXtProt AC  NX_P43026
Human Synonyms  BDA1C, BMP14, CDMP1, LAP4, OS5, SYM1B, SYNS2
Human Chr (Location)  20q11.2; chr20:35433351-35438247 (-)  GRCh38
Disease Associations  (9) Diseases Associated with Human GDF5
Alleles
and
phenotypes
All alleles(12) : Targeted(2) Gene trapped(1) Spontaneous(7) Chemically induced(2)
 
Homozygotes for null mutations exhibit slightly shortened long bones of the limbs, and drastically shortened bones of the feet, with some complete or partial fusions.
 
Human Diseases Modeled Using Mouse Gdf5 (8)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cartilage development, chondrocyte differentiation, ...
Component extracellular region, extracellular space
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (91 records)
Data Summary: Results (167)    Tissues (101)    Images (69)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 165
RT-PCR 2
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(13) Primer pair(3) Other(9)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015989 (Evidence)
Ensembl Gene ModelENSMUSG00000038259 (Evidence)
Entrez Gene14563 (Evidence)
UniGene4744
DFCITC1594980, TC1611368, TC1658451, TC1668315
DoTSDT.97410795
NIA Mouse Gene IndexU023546, U369692
Consensus CDS ProjectCCDS16958.1
International Mouse Knockout Project StatusGdf5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015989 VEGA Gene Model | MGI Sequence Detail 4345 C57BL/6J ±  kb
transcript OTTMUST00000038081 VEGA | MGI Sequence Detail 2320 Not Applicable 
polypeptide OTTMUSP00000017076 VEGA | MGI Sequence Detail 495 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002405 Inhibin, alpha subunit
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000281 growth/differentiation factor 5
References (Earliest) J:19596 Landauer W, Brachypodism - A recessive mutation of house-mice. J Hered. 1952;43:293-8
(Latest) J:205042 Osorio C, et al., Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development. Development. 2013 Dec;140(23):4751-62
All references(159)
Other
accession IDs
MGD-MRK-10041, MGD-MRK-1609, MGD-MRK-1633, MGI:88193

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory