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Gbx2 Gene Detail
Summary
  • Symbol
    Gbx2
  • Name
    gastrulation brain homeobox 2
  • Synonyms
    Gbx-2, MMoxA, Stra7
  • Feature Type
    protein coding gene
  • IDs
    MGI:95668
    NCBI Gene: 14472
  • Gene Overview
    MyGene.info: GBX2
Location & Maps
more
  • Sequence Map
    Chr1:89927956-89931179 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3224 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 45.06 cM, cytoband C5-E1
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    GBX2, gastrulation brain homeobox 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GBX2, gastrulation brain homeobox 2
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 2637
    neXtProt AC: NX_P52951

  • Chr Location
    2q37.2; chr2:236165236-236168009 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1138
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GBX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    74 phenotypes from 5 alleles in 9 genetic backgrounds
    28 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    10
  • Genomic Mutations
    2 involving Gbx2
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit neonatal lethality associated with vascular, neurological, skeletal, and craniofacial defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037278 VEGA Gene Model | MGI Sequence Detail 3224 C57BL/6J ±  kb
transcript OTTMUST00000096174 VEGA | MGI Sequence Detail 2135 Not Applicable  
polypeptide OTTMUSP00000053702 VEGA | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    Genomic 4
    cDNA 19
    Primer pair 4
    Other 11

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10011, MGD-MRK-10013, MGD-MRK-36498, MGI:107918
References
more
  • Summaries
    All 236
    Developmental Gene Expression 188
    Gene Ontology 10
    Phenotypes 43
  • Earliest
    J:2276 Murtha MT, et al., Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10711-5
  • Latest
    J:229950 Fujita M, et al., Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor. Mech Dev. 2016 Feb;139:65-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory