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Gbx2 Gene Detail
Summary
  • Symbol
    Gbx2
  • Name
    gastrulation brain homeobox 2
  • Synonyms
    Gbx-2, MMoxA, Stra7
  • Feature Type
    protein coding gene
  • IDs
    MGI:95668
    NCBI Gene: 14472
  • Gene Overview
    MyGene.info: GBX2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:89927962-89931176 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 45.06 cM, cytoband C5-E1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95668
protein coding gene Chr1:89927956-89931179 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016291
protein coding gene Chr1:91393528-91396751 (-)
A/J MGP_AJ_G0016272
protein coding gene Chr1:88126227-88129438 (-)
AKR/J MGP_AKRJ_G0016233
protein coding gene Chr1:90726681-90729894 (-)
BALB/cJ MGP_BALBcJ_G0016228
protein coding gene Chr1:88284540-88287743 (-)
C3H/HeJ MGP_C3HHeJ_G0016057
protein coding gene Chr1:90943368-90946575 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016687
protein coding gene Chr1:94929916-94933127 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014405
protein coding gene Chr1:82406014-82409187 (-)
CAST/EiJ MGP_CASTEiJ_G0015642
protein coding gene Chr1:90267758-90270973 (-)
CBA/J MGP_CBAJ_G0016033
protein coding gene Chr1:97977100-97980307 (-)
DBA/2J MGP_DBA2J_G0016136
protein coding gene Chr1:87353217-87356426 (-)
FVB/NJ MGP_FVBNJ_G0016135
protein coding gene Chr1:86369786-86373321 (-)
LP/J MGP_LPJ_G0016207
protein coding gene Chr1:92527601-92530824 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016160
protein coding gene Chr1:101250219-101253430 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016727
protein coding gene Chr1:90754360-90757575 (-)
PWK/PhJ MGP_PWKPhJ_G0015426
protein coding gene Chr1:86745698-86748981 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015209
protein coding gene Chr1:89654396-89658986 (-)
WSB/EiJ MGP_WSBEiJ_G0015700
protein coding gene Chr1:90485640-90488853 (-)



Homology
more
  • Human Ortholog
    GBX2, gastrulation brain homeobox 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GBX2, gastrulation brain homeobox 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2637
    neXtProt AC: NX_P52951
    UniProt: P52951

  • Chr Location
    2q37.2; chr2:236165236-236168009 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1138
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GBX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    75 phenotypes from 5 alleles in 9 genetic backgrounds
    28 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality associated with vascular, neurological, skeletal, and craniofacial defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14472 NCBI Gene Model | MGI Sequence Detail 3215 C57BL/6J ±  kb
    transcript NM_010262 RefSeq | MGI Sequence Detail 2126 C57BL/6  
    polypeptide P48031 UniProt | EBI | MGI Sequence Detail 348 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 4
      cDNA 25
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10011, MGD-MRK-10013, MGD-MRK-36498, MGI:107918
    References
    more
    • Summaries
      All 278
      Developmental Gene Expression 212
      Gene Ontology 11
      Phenotypes 57
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:278245 Guo Q, et al., Defining developmental diversification of diencephalon neurons through single cell gene expression profiling. Development. 2019 Apr 1;146(12)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory