About   Help   FAQ
Gbx2
Gene Detail
Symbol

Name
ID
Gbx2
gastrulation brain homeobox 2
MGI:95668
Synonyms
Gbx-2, MMoxA, Stra7
Feature Type
protein coding gene
Genetic Map
Chromosome 1
45.06 cM, cytoband C5-E1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:89927956-89931179 bp, - strand
From VEGA annotation of GRCm38

  3224 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1138  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: GBX2
Gene Tree: Gbx2

Human
homologs
GBX2, gastrulation brain homeobox 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2637
neXtProt AC: NX_P52951

Human Chr (Location): 2q37.2; chr2:236165236-236168009 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(2) Targeted(10)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality associated with vascular, neurological, skeletal, and craniofacial defects.
 
Interactions
Gbx2 interacts with 153 markers (Mir7-1, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process autonomic nervous system development, axon guidance, ...
Component nucleus
Function DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (179 records)
Data Summary: Results (547)    Tissues (293)    Images (155)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 491
RT-PCR 56
cDNA source data(18)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA GBX2 ; Xenbase gbx2, gbx2.2 ; ZFIN gbx2    NEW 
Molecular
reagents
All nucleic(38) Genomic(4) cDNA(19) Primer pair(4) Other(11)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037278 (Evidence)
Ensembl Gene Model ENSMUSG00000034486 (Evidence)
Entrez Gene 14472 (Evidence)
UniGene 204730
DFCI TC1589068
Consensus CDS Project CCDS15150.1
International Mouse Phenotyping Consortium Status Gbx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037278 VEGA Gene Model | MGI Sequence Detail 3224 C57BL/6J ±  kb
transcript OTTMUST00000096174 VEGA | MGI Sequence Detail 2135 Not Applicable 
polypeptide OTTMUSP00000053702 VEGA | MGI Sequence Detail 348 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000007882 homeobox protein GBX-2
References
(Earliest) J:2276 Murtha MT, et al., Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10711-5
(Latest) J:220860 Magnani D, et al., The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 2015 May 1;24(9):2578-93
All references(226)
Other
accession IDs
MGD-MRK-10011, MGD-MRK-10013, MGD-MRK-36498, MGI:107918

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory