About   Help   FAQ
Gbx2
Gene Detail
 Symbol
Name
ID
Gbx2
gastrulation brain homeobox 2
MGI:95668
Synonyms Gbx-2, MMoxA, Stra7
Feature Type protein coding gene
Genetic Map
Chromosome 1
45.06 cM, cytoband C5-E1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:89927956-89931179 bp, - strand
From VEGA annotation of GRCm38

  3224 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1138  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Gene Tree: Gbx2

Human
homologs
Human Homolog GBX2, gastrulation brain homeobox 2
NCBI Gene ID 2637
neXtProt AC  NX_P52951
Human Chr (Location)  2q37.2; chr2:236165664-236168009 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(2) Targeted(10)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality associated with vascular, neurological, skeletal, and craniofacial defects.
 
Interactions
Gbx2 interacts with 153 markers (Mir7-1, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process autonomic nervous system development, axon guidance, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (171 records)
Data Summary: Results (547)    Tissues (293)    Images (155)
Theiler Stages: 2, 3, 4, 5, 11, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 27, 28
Assay TypeResults
RNA in situ 491
RT-PCR 56
cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(4) cDNA(19) Primer pair(4) Other(11)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037278 (Evidence)
Ensembl Gene ModelENSMUSG00000034486 (Evidence)
Entrez Gene14472 (Evidence)
UniGene204730
DFCITC1589068
Consensus CDS ProjectCCDS15150.1
International Mouse Knockout Project StatusGbx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037278 VEGA Gene Model | MGI Sequence Detail 3224 C57BL/6J ±  kb
transcript OTTMUST00000096174 VEGA | MGI Sequence Detail 2135 Not Applicable 
polypeptide OTTMUSP00000053702 VEGA | MGI Sequence Detail 348 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000007882 homeobox protein GBX-2
References (Earliest) J:2276 Murtha MT, et al., Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10711-5
(Latest) J:206591 Di Giovannantonio LG, et al., Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity. Development. 2014 Jan;141(2):377-88
All references(219)
Other
accession IDs
MGD-MRK-10011, MGD-MRK-10013, MGD-MRK-36498, MGI:107918

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory