Gbx2 MGI Mouse Gene Detail - MGI:95668 - gastrulation brain homeobox 2

About Help FAQ

Gbx2 Gene Detail

Symbol

Gbx2
Name

gastrulation brain homeobox 2
Synonyms

Gbx-2, MMoxA, Stra7

Feature Type

protein coding gene
IDs

MGI:95668
NCBI Gene: 14472
Alliance

genome feature page
Transcription Start Sites

3 TSS
Regulated by

Rr602 (1 regulatory region)
Candidate for QTL

2 QTL

more

Sequence Map

Chr1:89855684-89858898 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 45.06 cM, cytoband C5-E1
Mapping Data

6 experiments

more

SNPs within 2kb

100 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_95668	protein coding gene	Chr1:89855678-89858901 (-)
129S1/SvImJ	ENSMUSG00200037323	protein coding gene	Chr1:87079608-87082831 (-)
A/J	ENSMUSG00195028450	protein coding gene	Chr1:86640615-86643840 (-)
AKR/J	ENSMUSG00220042322	protein coding gene	Chr1:86788819-86792042 (-)
BALB/cJ	ENSMUSG00180016098	protein coding gene	Chr1:86952245-86955470 (-)
C3H/HeJ	ENSMUSG00175001009	protein coding gene	Chr1:86824258-86827483 (-)
C57BL/6NJ	ENSMUSG00215025332	protein coding gene	Chr1:86755058-86758285 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014405	protein coding gene	Chr1:82406014-82409187 (-)
CAST/EiJ	ENSTCUG00005007247	protein coding gene	Chr1:86401329-86404560 (-)
CBA/J	ENSMUSG00210011779	protein coding gene	Chr1:86669595-86672818 (-)
DBA/2J	ENSMUSG00185016665	protein coding gene	Chr1:91131405-91134630 (-)
FVB/NJ	ENSMUSG00205025076	protein coding gene	Chr1:86071599-86074818 (-)
JF1/MsJ	ENSUMUG00000009241	protein coding gene	Chr1:89890622-89893861 (-)
LP/J	ENSMUSG00230015099	protein coding gene	Chr1:90415827-90419054 (-)
NOD/ShiLtJ	ENSMUSG00190030506	protein coding gene	Chr1:86714837-86718062 (-)
NZO/HlLtJ	ENSMUSG00225001830	protein coding gene	Chr1:94311974-94315199 (-)
PWK/PhJ	ENSLUMG00010036746	protein coding gene	Chr1:86289119-86292293 (-)
SPRET/EiJ	ENSMSPG00010045666	protein coding gene	Chr1:88310150-88313371 (-)
WSB/EiJ	ENSIUOG00005034419	protein coding gene	Chr1:86383973-86387202 (-)

more

Human Ortholog

GBX2, gastrulation brain homeobox 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GBX2, gastrulation brain homeobox 2
Links

HGNC:4186

NCBI Gene ID: 2637

UniProt: P52951
Chr Location

2q37.2; chr2:236161340-236168386 (-) GRCh38

MGI Vertebrate Homology

Gbx2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GBX2
Gene Tree

Gbx2

less

Phenotype Summary

75 phenotypes from 5 alleles in 9 genetic backgrounds
28 phenotypes from multigenic genotypes
79 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

1
Targeted

10
Genomic Mutations

2 involving Gbx2
Incidental Mutations

APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit neonatal lethality associated with vascular, neurological, skeletal, and craniofacial defects.

less

All GO Annotations

33
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1443
Tissues

368
cDNA Data

26
Literature Summary

251

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GBX2

Xenbase gbx2, gbx2.2

ZFIN gbx2

less

All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS15150.1

Ensembl

ENSMUSG00000034486 (Evidence)
NCBI Gene

14472

Representative Sequences				Length	Strain/Species	Flank
	genomic	14472	NCBI Gene Model \| MGI Sequence Detail	3215	C57BL/6J	± kb
	transcript	NM_010262	RefSeq \| MGI Sequence Detail	2126	ZRU/MplStud
	polypeptide	P48031	UniProt \| EBI \| MGI Sequence Detail	348	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000007882 homeobox protein GBX-2

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR042982 Homeobox protein GBX-1/2

IPR001356 Homeodomain

IPR009057 Homeodomain-like superfamily

IPR020479 Homeodomain, metazoa

less

All nucleic 85

Genomic 5

cDNA 31

Primer pair 10

Other 39

Antibodies 1

Microarray probesets 3

less

MGD-MRK-10011, MGD-MRK-10013, MGD-MRK-36498, MGI:107918

more

Summaries

All 342

Developmental Gene Expression 251

Gene Ontology 13

Phenotypes 79
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:377967 Roome RB, et al., Ontogeny of the spinal cord dorsal horn. Science. 2026 Jan 8;391(6781):eadx5781

Gbx2 expression regulated by:

Feature	Feature Type	Location	Reference
Rr602, regulatory region 602	enhancer	Chr1:89641474-89642633	J:317994

TSS for Gbx2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12904	Chr1:89858903-89858920 (-)	-14 bp
Tssr12903	Chr1:89858875-89858890 (-)	15 bp
Tssr12902	Chr1:89858405-89858430 (-)	480 bp

Gbx2 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Alcw1	Chr1, 80.33 cM	Chr1:170868354-171966357	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 1, several candidate genes were identified for Ap1q at 60 cM andAlcw1 at 95.8 cM. Candidate genes for Ap1q are Akp3 (51.7 cM), Gbx2 (65 cM), and Pam (57.5 cM). Candidate genes for Alcw1 are Adss, 2810484M10Rik, and Mark1.
Ap1q	Chr1, 63.28 cM	Chr1:146908199-167586222	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 1, several candidate genes were identified for Ap1q at 60 cM andAlcw1 at 95.8 cM. Candidate genes for Ap1q are Akp3 (51.7 cM), Gbx2 (65 cM), and Pam (57.5 cM). Candidate genes for Alcw1 are Adss, 2810484M10Rik, and Mark1.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24