Gbx2
Gene Detail

Symbol Name ID

Gbx2 gastrulation brain homeobox 2 MGI:95668

Synonyms

Gbx-2, MMoxA, Stra7

Feature Type

protein coding gene

Genetic Map

Chromosome 1

45.06 cM, cytoband C5-E1
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr1:89927962-89933290 bp, - strand From VEGA annotation of GRCm38   5329 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1138  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gbx2

Human homologs

Human Homolog		GBX2, gastrulation brain homeobox 2
NCBI Gene ID		2637
neXtProt AC		NX_P52951
Human Chr (Location)		2q37.2; chr2:237074307-237076652 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(9) Gene trapped(2)
 

Mice homozygous for a knock-out allele exhibit neonatal lethality associated with vascular, neurological, skeletal, and craniofacial defects.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	autonomic nervous system development, axon guidance, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (162 records)
Data Summary: Results (490)    Tissues (273)    Images (136)
Theiler Stages: 2, 3, 4, 5, 11, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	427
RT-PCR	63

cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(36) Genomic(4) cDNA(18) Primer pair(4) Other(10)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037278 (Evidence)
Ensembl Gene Model	ENSMUSG00000034486 (Evidence)
Entrez Gene	14472 (Evidence)
UniGene	204730
DFCI	TC1589068
Consensus CDS Project	CCDS15150.1
International Mouse Knockout Project Status	Gbx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037278	VEGA Gene Model | MGI Sequence Detail	5329	C57BL/6J
transcript	OTTMUST00000096174	VEGA | MGI Sequence Detail	4240	Not Applicable
polypeptide	OTTMUSP00000053702	VEGA | MGI Sequence Detail	348	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000007882	homeobox protein GBX-2

References

(Earliest) J:2276 Murtha MT, et al., Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10711-5
(Latest) J:192097 Li K, et al., Gbx2 plays an essential but transient role in the formation of thalamic nuclei. PLoS One. 2012;7(10):e47111
All references(207)

Other accession IDs

MGD-MRK-10011, MGD-MRK-10013, MGD-MRK-36498, MGI:107918