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Gata2 Gene Detail
Summary
  • Symbol
    Gata2
  • Name
    GATA binding protein 2
  • Synonyms
    Gata-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95662
    NCBI Gene: 14461
  • Gene Overview
    MyGene.info: GATA2
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:88193891-88207032 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 39.20 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95662
protein coding gene Chr6:88193437-88207032 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031007
protein coding gene Chr6:89578982-89594141 (+)
A/J MGP_AJ_G0030973
protein coding gene Chr6:86127541-86140790 (+)
AKR/J MGP_AKRJ_G0030904
protein coding gene Chr6:88615001-88628141 (+)
BALB/cJ MGP_BALBcJ_G0030986
protein coding gene Chr6:86125738-86138876 (+)
C3H/HeJ MGP_C3HHeJ_G0030724
protein coding gene Chr6:95832739-95847048 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031443
protein coding gene Chr6:91972700-91988142 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028625
protein coding gene Chr6:84297524-84306225 (+)
CAST/EiJ MGP_CASTEiJ_G0030095
protein coding gene Chr6:88702864-88715999 (+)
CBA/J MGP_CBAJ_G0030670
protein coding gene Chr6:95540986-95554170 (+)
DBA/2J MGP_DBA2J_G0030826
protein coding gene Chr6:85422075-85435220 (+)
FVB/NJ MGP_FVBNJ_G0030779
protein coding gene Chr6:84612756-84626619 (+)
LP/J MGP_LPJ_G0030903
protein coding gene Chr6:89614367-89628247 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030812
protein coding gene Chr6:99652961-99667075 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031470
protein coding gene Chr6:88464754-88477891 (+)
PWK/PhJ MGP_PWKPhJ_G0029810
protein coding gene Chr6:84393654-84406823 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029638
protein coding gene Chr6:87278585-87291733 (+)
WSB/EiJ MGP_WSBEiJ_G0030176
protein coding gene Chr6:88918448-88932780 (+)



Homology
more
  • Human Ortholog
    GATA2, GATA binding protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GATA2, GATA binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DCML, IMD21, MONOMAC, NFE1B
  • Links
    NCBI Gene ID: 2624
    neXtProt AC: NX_P23769
    UniProt: P23769

  • Chr Location
    3q21.3; chr3:128479422-128493187 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human GATA2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 14 alleles in 13 genetic backgrounds
    4 phenotypes from multigenic genotypes
    3 images
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants show reduced placental secretion of angiogenic factors, hematopoietic defects, enlarged pericardial sacs, reduced numbers of V2-expressing interneurons of ventral spinal cord, and die by embryonic day 11.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015053 Ensembl Gene Model | MGI Sequence Detail 13142 C57BL/6J ±  kb
    transcript ENSMUST00000015197 Ensembl | MGI Sequence Detail 3571 Not Applicable  
    polypeptide ENSMUSP00000015197 Ensembl | MGI Sequence Detail 480 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 6
      cDNA 28
      Primer pair 15
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10003, MGD-MRK-9999
    References
    more
    • Summaries
      All 291
      Developmental Gene Expression 161
      Gene Ontology 34
      Phenotypes 75
    • Earliest
      J:699 Zon LI, et al., GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 5;266(34):22948-53
    • Latest
      J:265807 Martin Gonzalez J, et al., A new genetic tool to improve immune-compromised mouse models: Derivation and CRISPR/Cas9-mediated targeting of NRG embryonic stem cell lines. Genesis. 2018 Sep;56(9):e23238

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory