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Gata2
Gene Detail
Symbol

Name
ID
Gata2
GATA binding protein 2
MGI:95662
Synonyms
Gata-2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
39.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr6:88193891-88207030 bp, + strand
From Ensembl annotation of GRCm38

  13140 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32030  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor, GATA-1/2/3 types
Gene Tree: Gata2

Human
homologs
Human Homolog GATA2, GATA binding protein 2
NCBI Gene ID 2624
neXtProt AC  NX_P23769
Human Synonyms  DCML, IMD21, MONOMAC, NFE1B
Human Chr (Location)  3q21.3; chr3:128479422-128493187 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human GATA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(1) Targeted(13)
 
Homozygous mutant show reduced placental secretion of angiogenic factors, hematopoietic defects, enlarged pericardial sacs, reduced numbers of V2-expressing interneurons of ventral spinal cord, and die by embryonic day 11.5.
 
Phenotype Images(3)
Interactions
Gata2 interacts with 210 markers (Mir16-1, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process cell differentiation, cell differentiation in hindbrain, ...
Component cytosol, mast cell granule, ...
Function C2H2 zinc finger domain binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (123 records)
Data Summary: Results (707)    Tissues (465)    Images (95)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 545
In situ reporter (knock in) 17
Northern blot 4
RT-PCR 139
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) Genomic(6) cDNA(25) Primer pair(13) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000015053 (Evidence)
Entrez Gene14461 (Evidence)
DFCITC1576139
DoTSDT.87072635, DT.94157556
NIA Mouse Gene IndexU007146
Consensus CDS ProjectCCDS20333.1
International Mouse Knockout Project StatusGata2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015053 Ensembl Gene Model | MGI Sequence Detail 13140 C57BL/6J ±  kb
transcript ENSMUST00000170089 Ensembl | MGI Sequence Detail 3133 Not Applicable 
polypeptide ENSMUSP00000128198 Ensembl | MGI Sequence Detail 480 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(9)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016374 Transcription factor, GATA-1/2/3
InterPro IPR000679 Zinc finger, GATA-type
InterPro IPR013088 Zinc finger, NHR/GATA-type
Protein Ontology PR:000007858 endothelial transcription factor GATA-2
References
(Earliest) J:699 Zon LI, et al., GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 5;266(34):22948-53
(Latest) J:213664 Ohneda K, et al., Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice. Mol Cell Biol. 2014 May;34(10):1812-26
All references(202)
Other
accession IDs
MGD-MRK-10003, MGD-MRK-9999

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory