Gata2
Gene Detail

Symbol Name ID

Gata2 GATA binding protein 2 MGI:95662

Synonyms

Gata-2

Feature Type

protein coding gene

Genetic Map

Chromosome 6

39.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr6:88198664-88207032 bp, + strand From NCBI annotation of GRCm38   8369 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32030  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor, GATA-1/2/3 types
Gene Tree: Gata2

Human homologs

Human Homolog		GATA2, GATA binding protein 2
NCBI Gene ID		2624
neXtProt AC		NX_P23769
Human Synonyms		DCML, MONOMAC, NFE1B
Human Chr (Location)		3q21.3; chr3:128198265-128212030 (-)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human GATA2

Alleles and phenotypes

All alleles(13) : Targeted(13)
 

Homozygous mutant show reduced placental secretion of angiogenic factors, hematopoietic defects, enlarged pericardial sacs, reduced numbers of V2-expressing interneurons of ventral spinal cord, and die by embryonic day 11.5.

 

Gene Ontology (GO) classifications

All GO classifications: (59 annotations)

Process	cell differentiation, cell differentiation in hindbrain, ...
Component	nucleus, protein complex
Function	C2H2 zinc finger domain binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (109 records)
Data Summary: Results (413)    Tissues (261)    Images (74)
Theiler Stages: 2, 3, 4, 5, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	261
Northern blot	4
RT-PCR	146

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(6) cDNA(22) Primer pair(13) Other(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000015053 (Evidence)
Entrez Gene	14461 (Evidence)
DFCI	TC1576139
DoTS	DT.87072635, DT.94157556
NIA Mouse Gene Index	U007146
Consensus CDS Project	CCDS20333.1
International Mouse Knockout Project Status	Gata2

Sequences

Length	Strain/Species
genomic	14461	NCBI Gene Model | MGI Sequence Detail	8369	C57BL/6J
transcript	NM_008090	RefSeq | MGI Sequence Detail	3258	C57BL/6
polypeptide	O09100	UniProt | EBI | MGI Sequence Detail	480	Not Applicable

All sequences(31) RefSeq(2) UniProt(5)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016374	Transcription factor, GATA-1/2/3
InterPro	IPR000679	Zinc finger, GATA-type
InterPro	IPR013088	Zinc finger, NHR/GATA-type
Protein Ontology	PR:000007858	endothelial transcription factor GATA-2

Graphical View of Protein Domain Structure

References

(Earliest) J:699 Zon LI, et al., GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 5;266(34):22948-53
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(184)

Other accession IDs

MGD-MRK-10003, MGD-MRK-9999