About   Help   FAQ
Gata2 Gene Detail
Summary
  • Symbol
    Gata2
  • Name
    GATA binding protein 2
  • Synonyms
    Gata-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95662
    NCBI Gene: 14461
  • Gene Overview
    MyGene.info: GATA2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:88193891-88207032 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13142 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 39.20 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    GATA2, GATA binding protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GATA2, GATA binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DCML, IMD21, MONOMAC, NFE1B
  • Links
    NCBI Gene ID: 2624
    neXtProt AC: NX_P23769
    UniProt: P23769

  • Chr Location
    3q21.3; chr3:128479422-128493187 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human GATA2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 14 alleles in 13 genetic backgrounds
    4 phenotypes from multigenic genotypes
    3 images
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants show reduced placental secretion of angiogenic factors, hematopoietic defects, enlarged pericardial sacs, reduced numbers of V2-expressing interneurons of ventral spinal cord, and die by embryonic day 11.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000057342 VEGA Gene Model | MGI Sequence Detail 13142 C57BL/6J ±  kb
    transcript OTTMUST00000141093 VEGA | MGI Sequence Detail 3571 Not Applicable  
    polypeptide OTTMUSP00000073783 VEGA | MGI Sequence Detail 480 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 6
      cDNA 28
      Primer pair 15
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10003, MGD-MRK-9999
    References
    more
    • Summaries
      All 289
      Developmental Gene Expression 160
      Gene Ontology 33
      Phenotypes 73
    • Earliest
      J:699 Zon LI, et al., GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 5;266(34):22948-53
    • Latest
      J:265280 Tolkachov A, et al., Loss of the hematopoietic stem cell factor GATA2 in the osteogenic lineage impairs trabecularization and mechanical strength of bone. Mol Cell Biol. 2018 Mar 26;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory