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Gata2 Gene Detail
Summary
  • Symbol
    Gata2
  • Name
    GATA binding protein 2
  • Synonyms
    Gata-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95662
    NCBI Gene: 14461
  • Gene Overview
    MyGene.info: GATA2
Location & Maps
more
  • Sequence Map
    Chr6:88193891-88207032 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13142 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 39.20 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    GATA2, GATA binding protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GATA2, GATA binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DCML, IMD21, MONOMAC, NFE1B
  • Links
    NCBI Gene ID: 2624
    neXtProt AC: NX_P23769

  • Chr Location
    3q21.3; chr3:128479422-128493187 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human GATA2 associations

Human Disease Mouse Models
       Immunodeficiency 21; IMD21   OMIM: 614172
Lymphedema, Primary, with Myelodysplasia   OMIM: 614038
Myelodysplastic Syndrome; MDS   OMIM: 614286
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 14 alleles in 13 genetic backgrounds
    4 phenotypes from multigenic genotypes
    3 images
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    17
  • Genomic Mutations
    1 involving Gata2
Homozygous mutant show reduced placental secretion of angiogenic factors, hematopoietic defects, enlarged pericardial sacs, reduced numbers of V2-expressing interneurons of ventral spinal cord, and die by embryonic day 11.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057342 VEGA Gene Model | MGI Sequence Detail 13142 C57BL/6J ±  kb
transcript OTTMUST00000141091 VEGA | MGI Sequence Detail 3135 Not Applicable  
polypeptide OTTMUSP00000073781 VEGA | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000007858 endothelial transcription factor GATA-2
  • InterPro Domains
    IPR029522 Transcription factor GATA-2
    IPR016374 Transcription factor, GATA-2/3
    IPR000679 Zinc finger, GATA-type
    IPR013088 Zinc finger, NHR/GATA-type
Molecular
Reagents
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  • All nucleic 47
    Genomic 6
    cDNA 25
    Primer pair 13
    Other 3

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-10003, MGD-MRK-9999
References
more
  • Summaries
    All 233
    Developmental Gene Expression 139
    Gene Ontology 33
    Phenotypes 57
  • Earliest
    J:699 Zon LI, et al., GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 5;266(34):22948-53
  • Latest
    J:233899 Li X, et al., Gata2 Is a Rheostat for Mesenchymal Stem Cell Fate in Male Mice. Endocrinology. 2016 Mar;157(3):1021-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory