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Gata2
Gene Detail
Symbol

Name
ID
Gata2
GATA binding protein 2
MGI:95662
Synonyms
Gata-2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
39.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr6:88193891-88207030 bp, + strand
From Ensembl annotation of GRCm38

  13140 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32030  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GATA2
Protein SuperFamily: transcription factor, GATA-1/2/3 types
Gene Tree: Gata2

Human
homologs
GATA2, GATA binding protein 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2624
neXtProt AC: NX_P23769

Human Synonyms: DCML, IMD21, MONOMAC, NFE1B

Human Chr (Location): 3q21.3; chr3:128479422-128493187 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human GATA2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(1) Spontaneous(1) Targeted(17)
Genomic Mutations involving Gata2 (1)
 
Homozygous mutant show reduced placental secretion of angiogenic factors, hematopoietic defects, enlarged pericardial sacs, reduced numbers of V2-expressing interneurons of ventral spinal cord, and die by embryonic day 11.5.
 
Phenotype Images(3)
Interactions
Gata2 interacts with 209 markers (Mir16-1, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (79 annotations)
Process cell differentiation, cell differentiation in hindbrain, ...
Component cytosol, mast cell granule, ...
Function C2H2 zinc finger domain binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (132 records)
Data Summary: Results (708)    Tissues (462)    Images (97)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 545
In situ reporter (knock in) 17
Northern blot 4
RT-PCR 139
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GATA2 ; Xenbase gata2 ; ZFIN gata2a, gata2b    NEW 
Molecular
reagents
All nucleic(47) Genomic(6) cDNA(25) Primer pair(13) Other(3)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000015053 (Evidence)
Entrez Gene 14461 (Evidence)
DFCI TC1576139
DoTS DT.87072635, DT.94157556
NIA Mouse Gene Index U007146
Consensus CDS Project CCDS20333.1
International Mouse Phenotyping Consortium Status Gata2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015053 Ensembl Gene Model | MGI Sequence Detail 13140 C57BL/6J ±  kb
transcript ENSMUST00000015197 Ensembl | MGI Sequence Detail 3241 Not Applicable 
polypeptide ENSMUSP00000015197 Ensembl | MGI Sequence Detail 480 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(5)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029522 Transcription factor GATA-2
InterPro IPR016374 Transcription factor, GATA-2/3
InterPro IPR000679 Zinc finger, GATA-type
InterPro IPR013088 Zinc finger, NHR/GATA-type
Protein Ontology PR:000007858 endothelial transcription factor GATA-2
References
(Earliest) J:699 Zon LI, et al., GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 5;266(34):22948-53
(Latest) J:222625 Ohmori S, et al., GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow. Blood. 2015 May 21;125(21):3306-15
All references(219)
Other
accession IDs
MGD-MRK-10003, MGD-MRK-9999

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory