Gas5 Gene Detail

Summary

• Symbol
  Gas5
• Name
  growth arrest specific 5
• Synonyms
  Gas-5, Snhg2

• Feature Type
  lncRNA gene
• IDs
  MGI:95659
  NCBI Gene: 14455
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr1:160862171-160866109 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 69.75 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  112 from dbSNP Build 142
• Strain Annotations
  18
• PCR
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95659	lncRNA gene	Chr1:160861992-160866116 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015120	unclassified non-coding RNA gene	Chr1:166285523-166289640 (+)
A/J	MGP_AJ_G0015094	unclassified non-coding RNA gene	Chr1:159517871-159521985 (+)
AKR/J	MGP_AKRJ_G0015057	unclassified non-coding RNA gene	Chr1:164386196-164390313 (+)
BALB/cJ	MGP_BALBcJ_G0015057	unclassified non-coding RNA gene	Chr1:160059536-160063644 (+)
C3H/HeJ	MGP_C3HHeJ_G0014880	unclassified non-coding RNA gene	Chr1:164587385-164591502 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0015513	unclassified non-coding RNA gene	Chr1:171932009-171936126 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013259	unclassified non-coding RNA gene	Chr1:151635810-151640057 (+)
CAST/EiJ	MGP_CASTEiJ_G0014434	unclassified non-coding RNA gene	Chr1:164196426-164200543 (+)
CBA/J	MGP_CBAJ_G0014859	unclassified non-coding RNA gene	Chr1:178013871-178017988 (+)
DBA/2J	MGP_DBA2J_G0014952	unclassified non-coding RNA gene	Chr1:158497256-158501364 (+)
FVB/NJ	MGP_FVBNJ_G0014963	unclassified non-coding RNA gene	Chr1:156906392-156910509 (+)
LP/J	MGP_LPJ_G0015034	unclassified non-coding RNA gene	Chr1:167375338-167379455 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0014990	unclassified non-coding RNA gene	Chr1:185587357-185591474 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0015552	unclassified non-coding RNA gene	Chr1:164204900-164209017 (+)
PWK/PhJ	MGP_PWKPhJ_G0014226	unclassified non-coding RNA gene	Chr1:157653285-157657388 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014014	unclassified non-coding RNA gene	Chr1:163100303-163104435 (+)
WSB/EiJ	MGP_WSBEiJ_G0014537	unclassified non-coding RNA gene	Chr1:164395134-164400127 (+)

Homology

• Human Ortholog
  GAS5, growth arrest specific 5

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  GAS5, growth arrest specific 5
  
• Synonyms
  NCRNA00030, SNHG2
• Links
  HGNC:16355

  NCBI Gene ID: 60674

  
  
• Chr Location
  1q25.1; chr1:173858559-173869045 (-)  GRCh38

---

• MGI Vertebrate Homology
  Gas5 stringent orthology
  1 human;1 mouse;1 zebrafish
  
• HCOP
  vertebrate homology predictions: GAS5
• Gene Tree
  Gas5
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotypes from 1 allele in 1 genetic background
  13 phenotype references
  

• All Mutations and Alleles
  167
• Chemically induced (other)
  2
• Endonuclease-mediated
  7
• Gene trapped
  158
• Genomic Mutations
  2 involving Gas5
• Find Mice (IMSR)
  63 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a null allele die during the embryonic period. Heterozygous mice develop osteoporosis and have impaired bone repair capacity.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  833
• Tissues
  120
• cDNA Data
  14
• Literature Summary
  11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  194
• RefSeq
  8
• UniProt
  2

• Ensembl
  ENSMUSG00000053332 (Evidence)
• NCBI Gene
  14455

Representative Sequences			Length	Strain/Species
genomic	14455	NCBI Gene Model | MGI Sequence Detail	3939	C57BL/6J
transcript	NR_166052	RefSeq | MGI Sequence Detail	550	C57BL/6
polypeptide	V9H1D0	UniProt | EBI | MGI Sequence Detail	41	Not Applicable

Protein
Information

• UniProt
  2 Sequences

Molecular
Reagents

• All nucleic 21

  cDNA 14

  Primer pair 6

  Other 1

  
  

  Microarray probesets 6

Other
Accession IDs

MGD-MRK-9990, MGD-MRK-9996

References

• Summaries
  All 51

  Developmental Gene Expression 11

  Gene Ontology 1

  Phenotypes 13
• Earliest
  J:9302 Schneider C, et al., Genes specifically expressed at growth arrest of mammalian cells. Cell. 1988 Sep 9;54(6):787-93
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Gas5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9671	Chr1:160862151-160862184 (+)	-3 bp
Tssr9672	Chr1:160862473-160862491 (+)	311 bp