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Gabra3
Gene Detail
Symbol

Name
ID
Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
MGI:95615
Synonyms
Gabra-3
Feature Type
protein coding gene
Genetic Map
Chromosome X
37.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
ChrX:72432681-72656848 bp, - strand
From VEGA annotation of GRCm38

  224168 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20218  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: GABRA3
Gene Tree: Gabra3

Human
homologs
GABRA3, gamma-aminobutyric acid (GABA) A receptor, alpha 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2556
neXtProt AC: NX_P34903

Human Chr (Location): Xq28; chrX:152166234-152451359 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF , CvDC )
 
Hemizygous males exhibit hyperactivity and an increased startle response with impaired prepulse inhibition.
 
Interactions
Gabra3 interacts with 296 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (98)    Tissues (53)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 51
RT-PCR 47
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GABRA3 ; Xenbase gabra6    NEW 
Molecular
reagents
All nucleic(21) Genomic(9) cDNA(10) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017849 (Evidence)
Ensembl Gene Model ENSMUSG00000031343 (Evidence)
Entrez Gene 14396 (Evidence)
DFCI TC1586082, TC1618518
DoTS DT.40183803, DT.91348041
NIA Mouse Gene Index U039444, U065279
Consensus CDS Project CCDS30187.1
International Mouse Phenotyping Consortium Status Gabra3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017849 VEGA Gene Model | MGI Sequence Detail 224168 C57BL/6J ±  kb
transcript OTTMUST00000043201 VEGA | MGI Sequence Detail 1790 Not Applicable 
polypeptide OTTMUSP00000019433 VEGA | MGI Sequence Detail 533 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(6) : SNPs within 2kb(548 from dbSNP Build 137)    SNPs within 2kb including multiple locations(550)
Protein-related
information
ResourceIDDescription
InterPro IPR006028 Gamma-aminobutyric acid A receptor
InterPro IPR005433 Gamma-aminobutyric-acid A receptor, alpha 3 subunit
InterPro IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology PR:000007768 gamma-aminobutyric acid receptor subunit alpha-3
References
(Earliest) J:12515 Barnard PJ, et al., Localization of the GABA-A receptor alpha-3 subunit gene on the mouse X Chromosome. Cytogenet Cell Genet. 1989;51:958
(Latest) J:205197 Christian CA, et al., Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20278-83
All references(70)
Other
accession IDs
MGD-MRK-9924, MGD-MRK-9929

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory