Gabra3
Gene Detail

Symbol Name ID

Gabra3 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 MGI:95615

Synonyms

Gabra-3

Feature Type

protein coding gene

Genetic Map

Chromosome X

37.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)

Sequence Map

ChrX:72432681-72656848 bp, - strand From VEGA annotation of GRCm38   224168 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Gabra3 ± 2 cM)

Gene Tree: Gabra3

Human ortholog

GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 NCBI Gene ID 2556
Human ChrX:151335634-151619831 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Hemizygous males exhibit hyperactivity and an increased startle response with impaired prepulse inhibition.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	chloride transport, gamma-aminobutyric acid signaling pathway, ...
Component	cell junction, chloride channel complex, ...
Function	chloride channel activity, extracellular ligand-gated ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (98)    Tissues (52)    Images (21)
Theiler Stages: 22, 23, 24, 25, 28

Assay Type	Results
In situ reporter (knock in)	51
RT-PCR	47

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(9) cDNA(10) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000017849 (Evidence)
Ensembl Gene Model	ENSMUSG00000031343 (Evidence)
Entrez Gene	14396 (Evidence)
DFCI	TC1586082, TC1618518
DoTS	DT.40183803, DT.91348041
NIA Mouse Gene Index	U039444, U065279
Consensus CDS Project	CCDS30187.1
International Mouse Knockout Project Status	Gabra3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017849	VEGA Gene Model | MGI Sequence Detail	224168	C57BL/6J
transcript	OTTMUST00000043201	VEGA | MGI Sequence Detail	1790	Not Applicable
polypeptide	OTTMUSP00000019433	VEGA | MGI Sequence Detail	533	Not Applicable

All sequences(32) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(6) : SNPs(445 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006028	Gamma-aminobutyric acid A receptor
InterPro	IPR005433	Gamma-aminobutyric-acid A receptor, alpha 3 subunit
InterPro	IPR001390	Gamma-aminobutyric-acid A receptor, alpha subunit
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology	PR:000007768	gamma-aminobutyric acid receptor subunit alpha-3

References

(Earliest) J:12515 Barnard PJ, et al., Localization of the GABA-A receptor alpha-3 subunit gene on the mouse X Chromosome. Cytogenet Cell Genet. 1989;51:958
(Latest) J:190498 Telegdy G, et al., Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice. Behav Brain Res. 2012 Jul 15;233(1):232-6
All references(70)

Other accession IDs

MGD-MRK-9924, MGD-MRK-9929