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Gabra3 Gene Detail
Summary
  • Symbol
    Gabra3
  • Name
    gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
  • Synonyms
    Gabra-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95615
    NCBI Gene: 14396
  • Gene Overview
    MyGene.info: GABRA3
Location & Maps
more
  • Sequence Map
    ChrX:72432681-72656848 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      224168 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.24 cM
  • Mapping Data
    22 experiments
Homology
more
  • Human Ortholog
    GABRA3, gamma-aminobutyric acid type A receptor alpha3 subunit
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GABRA3, gamma-aminobutyric acid type A receptor alpha3 subunit
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 2556
    neXtProt AC: NX_P34903

  • Chr Location
    Xq28; chrX:152166234-152451359 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    4
  • Incidental Mutations
    APF , CvDC
Hemizygous males exhibit hyperactivity and an increased startle response with impaired prepulse inhibition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017849 VEGA Gene Model | MGI Sequence Detail 224168 C57BL/6J ±  kb
transcript OTTMUST00000043201 VEGA | MGI Sequence Detail 1790 Not Applicable  
polypeptide OTTMUSP00000019433 VEGA | MGI Sequence Detail 533 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    540 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007768 gamma-aminobutyric acid receptor subunit alpha-3
  • InterPro Domains
    IPR005433 Gamma-aminobutyric-acid A receptor, alpha 3 subunit
    IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Molecular
Reagents
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  • All nucleic 21
    Genomic 9
    cDNA 10
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9924, MGD-MRK-9929
References
more
  • Summaries
    All 71
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:12515 Barnard PJ, et al., Localization of the GABA-A receptor alpha-3 subunit gene on the mouse X Chromosome. Cytogenet Cell Genet. 1989;51:958
  • Latest
    J:222724 Ralvenius WT, et al., Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype. Nat Commun. 2015;6:6803

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory