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Fst
Gene Detail
Symbol

Name
ID
Fst
follistatin
MGI:95586
Feature Type
protein coding gene
Genetic Map
Chromosome 13
64.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:114452262-114458730 bp, - strand
From Ensembl annotation of GRCm38

  6469 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7324  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: FST
Protein SuperFamily: follistatin
Gene Tree: Fst

Human
homologs
FST, follistatin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10468
neXtProt AC: NX_P19883

Human Synonyms: FS

Human Chr (Location): 5q11.2; chr5:53480341-53487134 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show retarded growth, reduced diaphragm and intercostal muscle mass that lead to neonatal respiratory failure, shiny tight skin, defects of the hard palate and thirteenth ribs, and abnormal whiskers and teeth. Some conditional mutations produce female reproductive defects.
 
Human Diseases Modeled in Mice Using Fst (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Fst interacts with 279 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process BMP signaling pathway, female gonad development, ...
Component cytoplasm, extracellular region, ...
Function activin binding, heparan sulfate proteoglycan binding
External Resources: FuncBase
Expression
Literature Summary: (93 records)
Data Summary: Results (637)    Tissues (297)    Images (126)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 529
Northern blot 12
RT-PCR 89
RNase protection 7
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FST ; Xenbase fst ; ZFIN fsta, fstb    NEW 
Molecular
reagents
All nucleic(42) cDNA(32) Primer pair(5) Other(5)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000021765 (Evidence)
Entrez Gene 14313 (Evidence)
UniGene 4913
DFCI TC1589268, TC1603892, TC1643878
DoTS DT.101725614, DT.40173377
NIA Mouse Gene Index U035199
Consensus CDS Project CCDS36787.1
International Mouse Phenotyping Consortium Status Fst
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021765 Ensembl Gene Model | MGI Sequence Detail 6469 C57BL/6J ±  kb
transcript ENSMUST00000022287 Ensembl | MGI Sequence Detail 2337 Not Applicable 
polypeptide ENSMUSP00000022287 Ensembl | MGI Sequence Detail 343 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003645 Follistatin-like, N-terminal
InterPro IPR015369 Follistatin/Osteonectin EGF domain
InterPro IPR002350 Kazal domain
InterPro IPR017878 TB domain
Protein Ontology PR:000000015 follistatin
References
(Earliest) J:16356 Nakamura T, et al., Activin-binding protein from rat ovary is follistatin. Science. 1990 Feb 16;247(4944):836-8
(Latest) J:220472 Zhao L, et al., Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1. Development. 2015 Mar 15;142(6):1083-8
All references(148)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-9880

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory