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Fst Gene Detail
Summary
  • Symbol
    Fst
  • Name
    follistatin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95586
    NCBI Gene: 14313
Location & Maps
more
  • Sequence Map
    Chr13:114452262-114458730 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6469 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FST, follistatin
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FST, follistatin
    Orthology source: HomoloGene
  • Synonyms
    FS
  • Links
    NCBI Gene ID: 10468
    neXtProt AC: NX_P19883

  • Chr Location
    5q11.2; chr5:53480341-53487134 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7324
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: FST
  • Protein SuperFamily
  • Gene Tree
    Fst
Human Diseases
more
  • Diseases
    1 with Fst mouse models

Human Disease Mouse Models
       Restrictive Dermopathy, Lethal   OMIM: 275210 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    64 phenotypes from 8 alleles in 6 genetic backgrounds
    15 phenotypes from multigenic genotypes
    1 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Targeted
    5
  • Transgenic
    6
  • Incidental Mutations
Homozygous null mice show retarded growth, reduced diaphragm and intercostal muscle mass that lead to neonatal respiratory failure, shiny tight skin, defects of the hard palate and thirteenth ribs, and abnormal whiskers and teeth. Some conditional mutations produce female reproductive defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021765 Ensembl Gene Model | MGI Sequence Detail 6469 C57BL/6J ±  kb
transcript ENSMUST00000022287 Ensembl | MGI Sequence Detail 2337 Not Applicable  
polypeptide ENSMUSP00000022287 Ensembl | MGI Sequence Detail 343 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    51 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    cDNA 32
    Primer pair 5
    Other 5

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-9880
References
more
  • Summaries
    All 144
    Developmental Gene Expression 93
    Diseases 1
    Gene Ontology 9
    Phenotypes 35
  • Earliest
    J:16356 Nakamura T, et al., Activin-binding protein from rat ovary is follistatin. Science. 1990 Feb 16;247(4944):836-8
  • Latest
    J:220472 Zhao L, et al., Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1. Development. 2015 Mar 15;142(6):1083-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory