About   Help   FAQ
Fst
Gene Detail
 Symbol
Name
ID
Fst
follistatin
MGI:95586
Feature Type protein coding gene
Genetic Map
Chromosome 13
64.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:114452262-114458730 bp, - strand
From NCBI annotation of GRCm38

  6469 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7324  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: follistatin
Gene Tree: Fst

Human
homologs
Human Homolog FST, follistatin
NCBI Gene ID 10468
neXtProt AC  NX_P19883
Human Synonyms  FS
Human Chr (Location)  5q11.2; chr5:53480355-53487134 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show retarded growth, reduced diaphragm and intercostal muscle mass that lead to neonatal respiratory failure, shiny tight skin, defects of the hard palate and thirteenth ribs, and abnormal whiskers and teeth. Some conditional mutations produce female reproductive defects.
 
Human Diseases Modeled Using Mouse Fst (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Fst interacts with 279 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process BMP signaling pathway, female gonad development, ...
Component cytoplasm, extracellular region, ...
Function activin binding, heparan sulfate proteoglycan binding
External Resources: FuncBase
Expression
Literature Summary: (86 records)
Data Summary: Results (601)    Tissues (290)    Images (126)
Theiler Stages: 4, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 527
Northern blot 12
RT-PCR 55
RNase protection 7
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(32) Primer pair(4) Other(4)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000021765 (Evidence)
Entrez Gene14313 (Evidence)
UniGene4913
DFCITC1589268, TC1603892, TC1643878
DoTSDT.101725614, DT.40173377
NIA Mouse Gene IndexU035199
Consensus CDS ProjectCCDS36787.1
International Mouse Knockout Project StatusFst
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14313 NCBI Gene Model | MGI Sequence Detail 6469 C57BL/6J ±  kb
transcript NM_008046 RefSeq | MGI Sequence Detail 2337 Not Specified 
polypeptide P47931 UniProt | EBI | MGI Sequence Detail 344 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003645 Follistatin-like, N-terminal
InterPro IPR015369 Follistatin/Osteonectin EGF domain
InterPro IPR002350 Kazal domain
InterPro IPR017878 TB domain
Protein Ontology PR:000000015 follistatin
Graphical View of Protein Domain Structure
References (Earliest) J:16356 Nakamura T, et al., Activin-binding protein from rat ovary is follistatin. Science. 1990 Feb 16;247(4944):836-8
(Latest) J:208789 Braga M, et al., Follistatin promotes adipocyte differentiation, browning, and energy metabolism. J Lipid Res. 2014 Mar;55(3):375-84
All references(144)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-9880

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory