Gene Expression Literature Summary

• Symbol: Fst
• Name: follistatin
• ID: MGI:95586

137 matching records from 137 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4	E4.5	E5.5	E6	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E19	E19.5	E	P
Immunohistochemistry (section)																			2		2		2		1		4		1		2		1	6		1		5
In situ RNA (section)						1				1	2	2		3	3	4	1	4	4		6	2	13	1	10		15	2	4		13	1	3	4	1	1	2	15
In situ RNA (whole mount)												1	1	3	6	6	4	4	4		2	2	7		7		4		3								2
Northern blot																												1		1		1
RT-PCR	1	2	1	1	1	2	4	2	1	1		1		3	1			2	5	2	9	3	17	3	17	4	13		5		2		3	1			2	16
cDNA clones																							1														1	2
RNase protection																1		1	2		1		2		1		2				1			1				2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fst  follistatin
Results	Reference
2	J:231522 Ahlfeld SK, Wang J, Gao Y, Snider P, Conway SJ, Initial Suppression of Transforming Growth Factor-beta Signaling and Loss of TGFBI Causes Early Alveolar Structural Defects Resulting in Bronchopulmonary Dysplasia. Am J Pathol. 2016 Apr;186(4):777-93
19*	J:17693 Albano RM, Arkell R, Beddington RS, Smith JC, Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain. Development. 1994 Apr;120(4):803-13
6*	J:105237 Albano RM, Smith JC, Follistatin expression in ES and F9 cells and in preimplantation mouse embryos. Int J Dev Biol. 1994 Sep;38(3):543-7
1	J:307093 Amato CM, Yao HH, Developmental and sexual dimorphic atlas of the prenatal mouse external genitalia at the single-cell level. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2103856118
6	J:128363 Arai KY, Nishiyama T, Developmental Changes in Extracellular Matrix Messenger RNAs in the Mouse Placenta During the Second Half of Pregnancy: Possible Factors Involved in the Regulation of Placental Extracellular Matrix Expression. Biol Reprod. 2007 Dec;77(6):923-33
1	J:130928 Bagheri-Fam S, Sim H, Bernard P, Jayakody I, Taketo MM, Scherer G, Harley VR, Loss of Fgfr2 leads to partial XY sex reversal. Dev Biol. 2008 Feb 1;314(1):71-83
2*	J:60095 Barrow JR, Stadler HS, Capecchi MR, Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse. Development. 2000 Mar;127(5):933-44
1	J:147876 Barsoum IB, Bingham NC, Parker KL, Jorgensen JS, Yao HH, Activation of the Hedgehog pathway in the mouse fetal ovary leads to ectopic appearance of fetal Leydig cells and female pseudohermaphroditism. Dev Biol. 2009 May 1;329(1):96-103
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
5	J:149988 Beites CL, Hollenbeck PL, Kim J, Lovell-Badge R, Lander AD, Calof AL, Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue. Development. 2009 Jul;136(13):2187-97
3*	J:264256 Bernardo AS, Jouneau A, Marks H, Kensche P, Kobolak J, Freude K, Hall V, Feher A, Polgar Z, Sartori C, Bock I, Louet C, Faial T, Kerstens HHD, Bouissou C, Parsonage G, Mashayekhi K, Smith JC, Lazzari G, Hyttel P, Stunnenberg HG, Huynen M, Pedersen RA, Dinnyes A, Mammalian embryo comparison identifies novel pluripotency genes associated with the naive or primed state. Biol Open. 2018 Aug 17;7(8):bio033282
6	J:219394 Boroviak T, Loos R, Bertone P, Smith A, Nichols J, The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
1	J:317270 Bottasso Arias N, Leesman L, Burra K, Snowball J, Shah RM, Mohanakrishnan M, Xu Y, Sinner D, BMP4 and WNT signaling interact to promote mouse tracheal mesenchyme morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2021 Dec 1;
3	J:98922 Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM, Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. Development. 2005 Jul;132(13):3045-54
7*	J:93500 Bouma GJ, Hart GT, Washburn LL, Recknagel AK, Eicher EM, Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development. Gene Expr Patterns. 2004 Nov;5(1):141-9
2*	J:156788 Bouma GJ, Hudson QJ, Washburn LL, Eicher EM, New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation. Biol Reprod. 2010 Feb;82(2):380-9
1	J:125196 Bouma GJ, Washburn LL, Albrecht KH, Eicher EM, Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14994-9
1*	J:271281 Bowles J, Feng CW, Ineson J, Miles K, Spiller CM, Harley VR, Sinclair AH, Koopman P, Retinoic Acid Antagonizes Testis Development in Mice. Cell Rep. 2018 Jul 31;24(5):1330-1341
1	J:150743 Buaas FW, Val P, Swain A, The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet. 2009 Aug 15;18(16):2989-3001
2	J:144095 Cassano M, Biressi S, Finan A, Benedetti L, Omes C, Boratto R, Martin F, Allegretti M, Broccoli V, Cusella De Angelis G, Comoglio PM, Basilico C, Torrente Y, Michieli P, Cossu G, Sampaolesi M, Magic-factor 1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis. PLoS One. 2008;3(9):e3223
3	J:292639 Cen C, Chen M, Zhou J, Zhang L, Duo S, Jiang L, Hou X, Gao F, Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development. Biol Reprod. 2020 Jun 23;103(1):60-69
2	J:133933 Chassot AA, Ranc F, Gregoire EP, Roepers-Gajadien HL, Taketo MM, Camerino G, de Rooij DG, Schedl A, Chaboissier MC, Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary. Hum Mol Genet. 2008 May 1;17(9):1264-77
1*	J:189715 Chen H, Palmer JS, Thiagarajan RD, Dinger ME, Lesieur E, Chiu H, Schulz A, Spiller C, Grimmond SM, Little MH, Koopman P, Wilhelm D, Identification of novel markers of mouse fetal ovary development. PLoS One. 2012;7(7):e41683
1	J:100352 Clotman F, Jacquemin P, Plumb-Rudewiez N, Pierreux CE, Van der Smissen P, Dietz HC, Courtoy PJ, Rousseau GG, Lemaigre FP, Control of liver cell fate decision by a gradient of TGFbeta signaling modulated by Onecut transcription factors. Genes Dev. 2005 Aug 15;19(16):1849-54
2*	J:177793 Combes AN, Bowles J, Feng CW, Chiu HS, Khoo PL, Jackson A, Little MH, Tam PP, Koopman P, Expression and functional analysis of Dkk1 during early gonadal development. Sex Dev. 2011;5(3):124-30
3*	J:183829 Correa SM, Washburn LL, Kahlon RS, Musson MC, Bouma GJ, Eicher EM, Albrecht KH, Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet. 2012 Apr;8(4):e1002569
1	J:92051 Cui S, Ross A, Stallings N, Parker KL, Capel B, Quaggin SE, Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. Development. 2004 Aug;131(16):4095-105
4	J:237421 Cunningham TJ, Colas A, Duester G, Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors. Biol Open. 2016 Dec 15;5(12):1821-1833
10	J:63374 De Groot E, Feijen A, Eib D, Zwijsen A, Sugino H, Martens G, Van Den Eijnden-Van Raaij AJ, Expression patterns of follistatin and two follistatin-related proteins during mouse development. Int J Dev Biol. 2000 Apr;44(3):327-30
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:107426 Dinapoli L, Batchvarov J, Capel B, FGF9 promotes survival of germ cells in the fetal testis. Development. 2006 Apr;133(8):1519-27
2	J:309996 Dumas S, Wallen-Mackenzie A, Developmental Co-expression of Vglut2 and Nurr1 in a Mes-Di-Encephalic Continuum Preceeds Dopamine and Glutamate Neuron Specification. Front Cell Dev Biol. 2019;7:307
2*	J:310178 Efimenko E, Padua MB, Manuylov NL, Fox SC, Morse DA, Tevosian SG, The transcription factor GATA4 is required for follicular development and normal ovarian function. Dev Biol. 2013 Sep 1;381(1):144-58
1*	J:86841 Elms P, Siggers P, Napper D, Greenfield A, Arkell R, Zic2 is required for neural crest formation and hindbrain patterning during mouse development. Dev Biol. 2003 Dec 15;264(2):391-406
1	J:68833 Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D, Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature. 2001 Apr 12;410(6830):825-30
1	J:77444 Faber SC, Robinson ML, Makarenkova HP, Lang RA, Bmp signaling is required for development of primary lens fiber cells. Development. 2002 Aug;129(15):3727-37
9*	J:21942 Feijen A, Goumans MJ, van den Eijnden-van Raaij AJ, Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins. Development. 1994 Dec;120(12):3621-37
4	J:49552 Ferguson CA, Tucker AS, Christensen L, Lau AL, Matzuk MM, Sharpe PT, Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition. Genes Dev. 1998 Aug 15;12(16):2636-49
1	J:71679 Freiman RN, Albright SR, Zheng S, Sha WC, Hammer RE, Tjian R, Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development. Science. 2001 Sep 14;293(5537):2084-7
1	J:204550 Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R, Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development. Dev Cell. 2013 Aug 26;26(4):416-30
2	J:238230 Furlan A, La Manno G, Lubke M, Haring M, Abdo H, Hochgerner H, Kupari J, Usoskin D, Airaksinen MS, Oliver G, Linnarsson S, Ernfors P, Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. Nat Neurosci. 2016 Oct;19(10):1331-40
1	J:152858 Garcia-Ortiz JE, Pelosi E, Omari S, Nedorezov T, Piao Y, Karmazin J, Uda M, Cao A, Cole SW, Forabosco A, Schlessinger D, Ottolenghi C, Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. BMC Dev Biol. 2009;9:36
2	J:139005 Geske MJ, Zhang X, Patel KK, Ornitz DM, Stappenbeck TS, Fgf9 signaling regulates small intestinal elongation and mesenchymal development. Development. 2008 Sep;135(17):2959-68
5	J:191095 Gierl MS, Gruhn WH, von Seggern A, Maltry N, Niehrs C, GADD45G functions in male sex determination by promoting p38 signaling and Sry expression. Dev Cell. 2012 Nov 13;23(5):1032-42
2	J:176045 Gokoffski KK, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof AL, Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development. 2011 Oct;138(19):4131-42
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1	J:316107 Han XH, Jin YR, Tan L, Kosciuk T, Lee JS, Yoon JK, Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/beta-catenin pathway in skeletal myogenesis. Mol Cell Biol. 2014 Feb;34(4):752-64
11	J:46029 Heikinheimo K, Begue-Kirn C, Ritvos O, Tuuri T, Ruch JV, The activin-binding protein follistatin is expressed in developing murine molar and induces odontoblast-like cell differentiation in vitro. J Dent Res. 1997 Oct;76(10):1625-36
2	J:344559 Hughes CHK, Smith OE, Meinsohn MC, Brunelle M, Gevry N, Murphy BD, Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2220849120
2	J:303384 Ikeda Y, Tagami A, Maekawa M, Nagai A, The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation. Sci Rep. 2021 Feb 24;11(1):4486
3	J:138181 Ikeda Y, Tanaka H, Esaki M, Effects of gestational diethylstilbestrol treatment on male and female gonads during early embryonic development. Endocrinology. 2008 Aug;149(8):3970-9
2	J:254511 Inoue K, Hirose M, Inoue H, Hatanaka Y, Honda A, Hasegawa A, Mochida K, Ogura A, The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is Imprinted and Essential for Placental Development. Cell Rep. 2017 May 2;19(5):949-956
1	J:101263 Ivins S, Lammerts van Beuren K, Roberts C, James C, Lindsay E, Baldini A, Ataliotis P, Scambler PJ, Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1. Dev Biol. 2005 Sep 15;285(2):554-69
1	J:327415 Jing J, Feng J, Yuan Y, Guo T, Lei J, Pei F, Ho TV, Chai Y, Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat Commun. 2022 Aug 16;13(1):4803
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3*	J:199186 Juuri E, Saito K, Lefebvre S, Michon F, Establishment of crown-root domain borders in mouse incisor. Gene Expr Patterns. 2013 Oct;13(7):255-64
8*	J:168597 Kashimada K, Pelosi E, Chen H, Schlessinger D, Wilhelm D, Koopman P, FOXL2 and BMP2 act cooperatively to regulate follistatin gene expression during ovarian development. Endocrinology. 2011 Jan;152(1):272-80
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6	J:336410 Koo HY, Kim MA, Min H, Hwang JY, Prajapati-DiNubila M, Kim KS, Matzuk MM, Park JW, Doetzlhofer A, Kim UK, Bok J, Follistatin regulates the specification of the apical cochlea responsible for low-frequency hearing in mammals. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2213099120
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2	J:246806 Li Y, Zhang L, Hu Y, Chen M, Han F, Qin Y, Chen M, Cui X, Duo S, Tang F, Gao F, beta-Catenin directs the transformation of testis Sertoli cells to ovarian granulosa-like cells by inducing Foxl2 expression. J Biol Chem. 2017 Oct 27;292(43):17577-17586
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2	J:309378 Naveau A, Zhang B, Meng B, Sutherland MT, Prochazkova M, Wen T, Marangoni P, Jones KB, Cox TC, Ganss B, Jheon AH, Klein OD, Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor. J Bone Miner Res. 2017 Nov;32(11):2219-2231
2	J:281436 Nicol B, Grimm SA, Chalmel F, Lecluze E, Pannetier M, Pailhoux E, Dupin-De-Beyssat E, Guiguen Y, Capel B, Yao HH, RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2. Nat Commun. 2019 Nov 11;10(1):5116
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1	J:99790 Ottolenghi C, Omari S, Garcia-Ortiz JE, Uda M, Crisponi L, Forabosco A, Pilia G, Schlessinger D, Foxl2 is required for commitment to ovary differentiation. Hum Mol Genet. 2005 Jul 15;14(14):2053-62
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3	J:276801 Prajapati-DiNubila M, Benito-Gonzalez A, Golden EJ, Zhang S, Doetzlhofer A, A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea. Elife. 2019 Jun 12;8:e47613
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