Fn1
Gene Detail

Symbol Name ID

Fn1 fibronectin 1 MGI:95566

Synonyms

Fn, Fn-1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

36.05 cM, cytoband C1-C5
Detailed Genetic Map ± 1 cM


Mapping data(41)

Sequence Map

Chr1:71585523-71653171 bp, - strand From NCBI annotation of GRCm38   67649 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Gene Tree: Fn1

Human homologs

Human Homolog		FN1, fibronectin 1
NCBI Gene ID		2335
neXtProt AC		NX_P02751
Human Synonyms		CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF
Human Chr (Location)		2q34; chr2:216225177-216300791 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human FN1

Alleles and phenotypes

All alleles(64) : Targeted(12) Gene trapped(52)
 

Mutants are defective in mesodermal function. Null mutants are embryonic lethal with major patterning and organizational defects. Conditional mutants live and show increased neuronal apoptosis and susceptibility to induced cerebral ischemia.

 

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	acute-phase response, angiogenesis, ...
Component	apical plasma membrane, basement membrane, ...
Function	heparin binding, mercury ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (197 records)
Data Summary: Results (188)    Tissues (93)    Images (70)
Theiler Stages: 11, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	91
RNA in situ	47
Northern blot	6
Western blot	10
RT-PCR	34

cDNA source data(952)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(973) Genomic(3) cDNA(959) Primer pair(6) Other(5)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000026193 (Evidence)
Entrez Gene	14268 (Evidence)
UniGene	193099
DoTS	DT.101157358, DT.101248764, DT.101398469, DT.101710166, DT.110890753, DT.110890869, DT.55107293, DT.55118698, DT.87032318, DT.91338052, DT.94279475, DT.94279531, DT.94302894, DT.97340806
NIA Mouse Gene Index	U021455
PDB	1MFN, 2MFN
Consensus CDS Project	CCDS15031.1
International Mouse Knockout Project Status	Fn1

Sequences

Length	Strain/Species
genomic	14268	NCBI Gene Model | MGI Sequence Detail	67649	C57BL/6J
transcript	NM_010233	RefSeq | MGI Sequence Detail	8425	C57BL/6
polypeptide	P11276	UniProt | EBI | MGI Sequence Detail	2477	Not Applicable

All sequences(97) RefSeq(14) UniProt(14)

Polymorphisms

RFLP(11) : SNPs within 2kb(601 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000083	Fibronectin, type I
InterPro	IPR000562	Fibronectin, type II, collagen-binding
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR013806	Kringle-like fold
Protein Ontology	PR:000007581	fibronectin

Graphical View of Protein Domain Structure

References

(Earliest) J:37302 Kimata K, et al., Participation of two different mesenchymes in the developing mouse mammary gland: synthesis of basement membrane components by fat pad precursor cells. J Embryol Exp Morphol. 1985 Oct;89:243-57
(Latest) J:195324 Hoerder-Suabedissen A, et al., Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3555-60
All references(348)

Other accession IDs

MGD-MRK-9847, MGD-MRK-9848