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Fn1 Gene Detail
Summary
  • Symbol
    Fn1
  • Name
    fibronectin 1
  • Synonyms
    Fn, Fn-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95566
    NCBI Gene: 14268
  • Gene Overview
    MyGene.info: FN1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:71585520-71653200 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67681 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 36.05 cM, cytoband C1-C5
  • Mapping Data
    42 experiments
Homology
more
  • Human Ortholog
    FN1, fibronectin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FN1, fibronectin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, SMDCF
  • Links
    NCBI Gene ID: 2335
    neXtProt AC: NX_P02751
    UniProt: P02751

  • Chr Location
    2q35; chr2:215360440-215436167 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1533
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FN1
  • Gene Tree
    Fn1
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 13 alleles in 13 genetic backgrounds
    5 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutants are defective in mesodermal function. Null mutants are embryonic lethal with major patterning and organizational defects. Conditional mutants live and show increased neuronal apoptosis and susceptibility to induced cerebral ischemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000048807 VEGA Gene Model | MGI Sequence Detail 67681 C57BL/6J ±  kb
    transcript OTTMUST00000124858 VEGA | MGI Sequence Detail 8315 Not Applicable  
    polypeptide OTTMUSP00000067843 VEGA | MGI Sequence Detail 2477 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      601 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 987
      Genomic 3
      cDNA 968
      Primer pair 9
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9847, MGD-MRK-9848
    References
    more
    • Summaries
      All 484
      Developmental Gene Expression 284
      Gene Ontology 29
      Phenotypes 73
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:264344 Kumra H, et al., Roles of fibronectin isoforms in neonatal vascular development and matrix integrity. PLoS Biol. 2018 Jul;16(7):e2004812

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory