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Fn1 Gene Detail
Summary
  • Symbol
    Fn1
  • Name
    fibronectin 1
  • Synonyms
    Fn, Fn-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95566
    NCBI Gene: 14268
  • Gene Overview
    MyGene.info: FN1
Location & Maps
more
  • Sequence Map
    Chr1:71585520-71653200 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67681 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 36.05 cM, cytoband C1-C5
  • Mapping Data
    41 experiments
Homology
more
  • Human Ortholog
    FN1, fibronectin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FN1, fibronectin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF
  • Links
    NCBI Gene ID: 2335
    neXtProt AC: NX_P02751

  • Chr Location
    2q34; chr2:215360454-215436167 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1533
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FN1
  • Gene Tree
    Fn1
Human Diseases
more
  • Diseases
    2 with human FN1 associations

Human Disease Mouse Models
       Glomerulopathy with Fibronectin Deposits 2; GFND2   OMIM: 601894
Plasma Fibronectin Deficiency   OMIM: 614101
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 13 alleles in 13 genetic backgrounds
    5 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    67
  • Chemically induced (other)
    1
  • Gene trapped
    52
  • Radiation induced
    1
  • Targeted
    13
  • Genomic Mutations
    2 involving Fn1
  • Incidental Mutations
Mutants are defective in mesodermal function. Null mutants are embryonic lethal with major patterning and organizational defects. Conditional mutants live and show increased neuronal apoptosis and susceptibility to induced cerebral ischemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048807 VEGA Gene Model | MGI Sequence Detail 67681 C57BL/6J ±  kb
transcript OTTMUST00000124858 VEGA | MGI Sequence Detail 8315 Not Applicable  
polypeptide OTTMUSP00000067843 VEGA | MGI Sequence Detail 2477 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    601 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 982
    Genomic 3
    cDNA 965
    Primer pair 8
    Other 6

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-9847, MGD-MRK-9848
References
more
  • Summaries
    All 407
    Developmental Gene Expression 240
    Gene Ontology 26
    Phenotypes 64
  • Earliest
    J:37302 Kimata K, et al., Participation of two different mesenchymes in the developing mouse mammary gland: synthesis of basement membrane components by fat pad precursor cells. J Embryol Exp Morphol. 1985 Oct;89:243-57
  • Latest
    J:231307 de Almeida PG, et al., Fibronectin assembly during early embryo development: A versatile communication system between cells and tissues. Dev Dyn. 2016 Apr;245(4):520-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory