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Fn1
Gene Detail
 Symbol
Name
ID
Fn1
fibronectin 1
MGI:95566
Synonyms Fn, Fn-1
Feature Type protein coding gene
Genetic Map
Chromosome 1
36.05 cM, cytoband C1-C5
Detailed Genetic Map ± 1 cM


Mapping data(41)
Sequence Map
Chr1:71585520-71653200 bp, - strand
From VEGA annotation of GRCm38

  67681 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fn1

Human
homologs
Human Homolog FN1, fibronectin 1
NCBI Gene ID 2335
neXtProt AC  NX_P02751
Human Synonyms  CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF
Human Chr (Location)  2q34; chr2:215360454-215436167 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human FN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(64) : Gene trapped(52) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Mutants are defective in mesodermal function. Null mutants are embryonic lethal with major patterning and organizational defects. Conditional mutants live and show increased neuronal apoptosis and susceptibility to induced cerebral ischemia.
 
Interactions
Fn1 interacts with 191 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process acute-phase response, angiogenesis, ...
Component apical plasma membrane, basal lamina, ...
Function heparin binding, integrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (209 records)
Data Summary: Results (215)    Tissues (107)    Images (81)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 106
RNA in situ 47
Northern blot 6
Western blot 22
RT-PCR 34
cDNA source data(958)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(979) Genomic(3) cDNA(965) Primer pair(6) Other(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000048807 (Evidence)
Ensembl Gene ModelENSMUSG00000026193 (Evidence)
Entrez Gene14268 (Evidence)
UniGene193099
DoTSDT.101157358, DT.101248764, DT.101398469, DT.101710166, DT.110890753, DT.110890869, DT.55107293, DT.55118698, DT.87032318, DT.91338052, DT.94279475, DT.94279531, DT.94302894, DT.97340806
NIA Mouse Gene IndexU021455
PDB1MFN, 2MFN
Consensus CDS ProjectCCDS15031.1
International Mouse Knockout Project StatusFn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048807 VEGA Gene Model | MGI Sequence Detail 67681 C57BL/6J ±  kb
transcript OTTMUST00000124858 VEGA | MGI Sequence Detail 8315 Not Applicable 
polypeptide OTTMUSP00000067843 VEGA | MGI Sequence Detail 2477 Not Applicable 

For the selected sequences
All sequences(136) RefSeq(22) UniProt(14)
Polymorphisms RFLP(11) : SNPs within 2kb(601 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000083 Fibronectin, type I
InterPro IPR000562 Fibronectin, type II, collagen-binding
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR013806 Kringle-like fold
Protein Ontology PR:000007581 fibronectin
References (Earliest) J:37302 Kimata K, et al., Participation of two different mesenchymes in the developing mouse mammary gland: synthesis of basement membrane components by fat pad precursor cells. J Embryol Exp Morphol. 1985 Oct;89:243-57
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(365)
Other
accession IDs
MGD-MRK-9847, MGD-MRK-9848

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory