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Flt4 Gene Detail
Summary
  • Symbol
    Flt4
  • Name
    FMS-like tyrosine kinase 4
  • Synonyms
    Flt-4, VEGFR3, VEGFR-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95561
    NCBI Gene: 14257
  • Gene Overview
    MyGene.info: FLT4
Location & Maps
more
  • Sequence Map
    Chr11:49609263-49652739 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43477 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 29.69 cM, cytoband A5-B1
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    FLT4, fms related tyrosine kinase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FLT4, fms related tyrosine kinase 4
    Orthology source: HomoloGene
  • Synonyms
    FLT-4, FLT41, LMPH1A, PCL, VEGFR3, VEGFR-3
  • Links
    NCBI Gene ID: 2324
    neXtProt AC: NX_P35916

  • Chr Location
    5q35.3; chr5:180601506-180650271 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Flt4 mouse models; 2 with human FLT4 associations

Human Disease Mouse Models
       Lymphedema, Hereditary, IA; LMPH1A   OMIM: 153100 View 1 model
       Hemangioma, Capillary Infantile   OMIM: 602089
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 6 alleles in 6 genetic backgrounds
    14 phenotypes from multigenic genotypes
    2 images
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Targeted
    12
  • Transgenic
    1
  • Genomic Mutations
    1 involving Flt4
  • Incidental Mutations
Embryos homozygous for a targeted null mutation show growth retardation, vascular abnormalities, severe anemia and die from cardiovascular failure at embryonic day 9.5. Heterozygotes for another mutation show abdominal chylous ascites, abnormal lymphaticvessels, and lymphedema.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005554 VEGA Gene Model | MGI Sequence Detail 43477 C57BL/6J ±  kb
transcript OTTMUST00000012349 VEGA | MGI Sequence Detail 6255 Not Applicable  
polypeptide OTTMUSP00000005713 VEGA | MGI Sequence Detail 1363 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    132 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007565 vascular endothelial growth factor receptor 3
  • EC
  • InterPro Domains
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
    IPR009137 Vascular endothelial growth factor receptor 3 (VEGFR3)
Molecular
Reagents
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  • All nucleic 28
    Genomic 1
    cDNA 21
    Primer pair 5
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1984, MGD-MRK-9835, MGD-MRK-9839, MGI:2144119, MGI:88402
References
more
  • Summaries
    All 188
    Developmental Gene Expression 109
    Diseases 2
    Gene Ontology 15
    Phenotypes 52
  • Earliest
    J:13981 Lyon MF, et al., Chylous ascites (Chy). Mouse News Lett. 1984;71:26
  • Latest
    J:232444 Li S, et al., Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod. 2016 Feb;94(2):41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory