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Gene Detail
FMS-like tyrosine kinase 4
Synonyms Flt-4, VEGFR3, VEGFR-3
Feature Type protein coding gene
Genetic Map
Chromosome 11
29.69 cM, cytoband A5-B1
Detailed Genetic Map ± 1 cM

Mapping data(12)
Sequence Map
Chr11:49609263-49652739 bp, + strand
From VEGA annotation of GRCm38

  43477 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:7321  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: vascular endothelial growth factor receptor
Gene Tree: Flt4

Human Homolog FLT4, fms-related tyrosine kinase 4
NCBI Gene ID 2324
neXtProt AC  NX_P35916
Human Synonyms  FLT41, LMPH1A, PCL, VEGFR3
Human Chr (Location)  5q35.3; chr5:180601506-180649624 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human FLT4
alleles, and
All mutations/alleles(11) : Chemically induced (ENU)(1) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
Embryos homozygous for a targeted null mutation show growth retardation, vascular abnormalities, severe anemia and die from cardiovascular failure at embryonic day 9.5. Heterozygotes for another mutation show abdominal chylous ascites, abnormal lymphatic vessels, and lymphedema.
Human Diseases Modeled Using Mouse Flt4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Flt4 interacts with 242 markers (Mir10a, Mir18, Mir18b, ...)
Gene Ontology
All GO classifications: (61 annotations)
Process angiogenesis, blood vessel morphogenesis, ...
Component cytoplasm, integral component of membrane, ...
Function ATP binding, growth factor binding, ...
External Resources: FuncBase
Literature Summary: (89 records)
Data Summary: Results (128)    Tissues (81)    Images (56)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 36
RNA in situ 63
RNase protection 8
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(28) Genomic(1) cDNA(21) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000005554 (Evidence)
Ensembl Gene ModelENSMUSG00000020357 (Evidence)
Entrez Gene14257 (Evidence)
DFCITC1587041, TC1678295
DoTSDT.101343506, DT.40158891, DT.489571
Consensus CDS ProjectCCDS24618.1
International Mouse Knockout Project StatusFlt4
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005554 VEGA Gene Model | MGI Sequence Detail 43477 C57BL/6J ±  kb
transcript OTTMUST00000012349 VEGA | MGI Sequence Detail 6255 Not Applicable 
polypeptide OTTMUSP00000005713 VEGA | MGI Sequence Detail 1363 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(136 from dbSNP Build 137)    SNPs within 2kb including multiple locations(144)
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
InterPro IPR009137 Tyrosine-protein kinase, vascular endothelial growth factor receptor 3 (VEGFR3), N-terminal
Protein Ontology PR:000007565 vascular endothelial growth factor receptor 3
References (Earliest) J:13981 Lyon MF, et al., Chylous ascites (Chy). Mouse News Lett. 1984;71:26
(Latest) J:209991 Zhang Y, et al., Activation of vascular endothelial growth factor receptor-3 in macrophages restrains TLR4-NF-kappaB signaling and protects against endotoxin shock. Immunity. 2014 Apr 17;40(4):501-14
All references(161)
Disease annotation references (2)
accession IDs
MGD-MRK-1984, MGD-MRK-9835, MGD-MRK-9839, MGI:2144119, MGI:88402

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory