Flt4
Gene Detail

Symbol Name ID

Flt4 FMS-like tyrosine kinase 4 MGI:95561

Synonyms

Flt-4, VEGFR3, VEGFR-3

Feature Type

protein coding gene

Genetic Map

Chromosome 11

29.69 cM, cytoband A5-B1
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr11:49609263-49652739 bp, + strand From VEGA annotation of GRCm38   43477 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7321  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: vascular endothelial growth factor receptor
Gene Tree: Flt4

Human homologs

Human Homolog		FLT4, fms-related tyrosine kinase 4
NCBI Gene ID		2324
neXtProt AC		NX_P35916
Human Synonyms		FLT41, LMPH1A, PCL, VEGFR3
Human Chr (Location)		5q35.3; chr5:180028506-180076624 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human FLT4

Alleles and phenotypes

All alleles(11) : Targeted(10) Chemically induced(1)
 

Embryos homozygous for a targeted null mutation show growth retardation, vascular abnormalities, severe anemia and die from cardiovascular failure at embryonic day 9.5. Heterozygotes for another mutation show abdominal chylous ascites, abnormal lymphatic vessels, and lymphedema.

 
Human Diseases Modeled Using Mouse Flt4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (55 annotations)

Process	angiogenesis, blood vessel morphogenesis, ...
Component	cytoplasm, integral to membrane, ...
Function	ATP binding, growth factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (83 records)
Data Summary: Results (106)    Tissues (65)    Images (38)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	63
RT-PCR	21
RNase protection	8

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) Genomic(1) cDNA(21) Primer pair(5) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000005554 (Evidence)
Ensembl Gene Model	ENSMUSG00000020357 (Evidence)
Entrez Gene	14257 (Evidence)
UniGene	3291
DFCI	TC1587041, TC1678295
DoTS	DT.101343506, DT.40158891, DT.489571
EC	2.7.10.1
Consensus CDS Project	CCDS24618.1
International Mouse Knockout Project Status	Flt4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005554	VEGA Gene Model | MGI Sequence Detail	43477	C57BL/6J
transcript	OTTMUST00000012349	VEGA | MGI Sequence Detail	6255	Not Applicable
polypeptide	OTTMUSP00000005713	VEGA | MGI Sequence Detail	1363	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(127 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR001824	Tyrosine-protein kinase, receptor class III, conserved site
InterPro	IPR009137	Tyrosine-protein kinase, vascular endothelial growth factor receptor 3 (VEGFR3), N-terminal
InterPro	IPR009134	Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal
Protein Ontology	PR:000007565	vascular endothelial growth factor receptor 3

References

(Earliest) J:13981 Lyon MF, et al., Chylous ascites (Chy). Mouse News Lett. 1984;71:26
(Latest) J:195520 Platt AM, et al., Normal Dendritic Cell Mobilization to Lymph Nodes under Conditions of Severe Lymphatic Hypoplasia. J Immunol. 2013 May 1;190(9):4608-20
All references(151)

Other accession IDs

MGD-MRK-1984, MGD-MRK-9835, MGD-MRK-9839, MGI:2144119, MGI:88402