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Flt4
Gene Detail
Symbol

Name
ID
Flt4
FMS-like tyrosine kinase 4
MGI:95561
Synonyms
Flt-4, VEGFR3, VEGFR-3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
29.69 cM, cytoband A5-B1
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr11:49609263-49652739 bp, + strand
From VEGA annotation of GRCm38

  43477 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7321  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FLT4
Protein SuperFamily: vascular endothelial growth factor receptor
Gene Tree: Flt4

Human
homologs
FLT4, fms-related tyrosine kinase 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2324
neXtProt AC: NX_P35916

Human Synonyms: FLT41, LMPH1A, PCL, VEGFR3

Human Chr (Location): 5q35.3; chr5:180601506-180650271 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human FLT4

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(1) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a targeted null mutation show growth retardation, vascular abnormalities, severe anemia and die from cardiovascular failure at embryonic day 9.5. Heterozygotes for another mutation show abdominal chylous ascites, abnormal lymphatic vessels, and lymphedema.
 
Human Diseases Modeled in Mice Using Flt4 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Flt4 interacts with 241 markers (Mir10a, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process angiogenesis, blood vessel morphogenesis, ...
Component cytoplasm, integral component of membrane, ...
Function ATP binding, growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (100 records)
Data Summary: Results (133)    Tissues (84)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 41
RNA in situ 63
RT-PCR 21
RNase protection 8
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FLT4 ; Xenbase LOC100493801    NEW 
Molecular
reagents
All nucleic(28) Genomic(1) cDNA(21) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000005554 (Evidence)
Ensembl Gene Model ENSMUSG00000020357 (Evidence)
Entrez Gene 14257 (Evidence)
UniGene 3291
DFCI TC1587041, TC1678295
DoTS DT.101343506, DT.40158891, DT.489571
EC 2.7.10.1
Consensus CDS Project CCDS24618.1
International Mouse Phenotyping Consortium Status Flt4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005554 VEGA Gene Model | MGI Sequence Detail 43477 C57BL/6J ±  kb
transcript OTTMUST00000012349 VEGA | MGI Sequence Detail 6255 Not Applicable 
polypeptide OTTMUSP00000005713 VEGA | MGI Sequence Detail 1363 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(136 from dbSNP Build 137)    SNPs within 2kb including multiple locations(144)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
InterPro IPR009137 Tyrosine-protein kinase, vascular endothelial growth factor receptor 3 (VEGFR3), N-terminal
Protein Ontology PR:000007565 vascular endothelial growth factor receptor 3
References
(Earliest) J:13981 Lyon MF, et al., Chylous ascites (Chy). Mouse News Lett. 1984;71:26
(Latest) J:219810 Qu X, et al., Tie1 is required for lymphatic valve and collecting vessel development. Dev Biol. 2015 Mar 1;399(1):117-28
All references(175)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1984, MGD-MRK-9835, MGD-MRK-9839, MGI:2144119, MGI:88402

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory