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Flt4 Gene Detail
Summary
  • Symbol
    Flt4
  • Name
    FMS-like tyrosine kinase 4
  • Synonyms
    Flt-4, VEGFR3, VEGFR-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95561
    NCBI Gene: 14257
  • Gene Overview
    MyGene.info: FLT4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:49609679-49652739 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 29.69 cM, cytoband A5-B1
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95561
protein coding gene Chr11:49609263-49652739 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018234
protein coding gene Chr11:48736562-48788357 (+)
A/J MGP_AJ_G0018202
protein coding gene Chr11:46860584-46909608 (+)
AKR/J MGP_AKRJ_G0018172
protein coding gene Chr11:48371154-48415923 (+)
BALB/cJ MGP_BALBcJ_G0018172
protein coding gene Chr11:47166655-47195407 (+)
C3H/HeJ MGP_C3HHeJ_G0017985
protein coding gene Chr11:48367409-48411206 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018623
protein coding gene Chr11:50167137-50242774 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016275
protein coding gene Chr11:44479385-44535973 (+)
CAST/EiJ MGP_CASTEiJ_G0017547
protein coding gene Chr11:48318009-48375429 (+)
CBA/J MGP_CBAJ_G0017960
protein coding gene Chr11:52519630-52580703 (+)
DBA/2J MGP_DBA2J_G0018067
protein coding gene Chr11:46681010-46738891 (+)
FVB/NJ MGP_FVBNJ_G0018061
protein coding gene Chr11:46312914-46342023 (+)
LP/J MGP_LPJ_G0018142
protein coding gene Chr11:49059153-49115642 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018086
protein coding gene Chr11:54076757-54123614 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018667
protein coding gene Chr11:48471193-48514061 (+)
PWK/PhJ MGP_PWKPhJ_G0017325
protein coding gene Chr11:47065360-47109674 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017120
protein coding gene Chr11:48160769-48214916 (+)
WSB/EiJ MGP_WSBEiJ_G0017600
protein coding gene Chr11:48107497-48159185 (+)



Homology
more
  • Human Ortholog
    FLT4, fms related tyrosine kinase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FLT4, fms related tyrosine kinase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FLT-4, FLT41, LMPH1A, LMPHM1, PCL, VEGFR3, VEGFR-3
  • Links
    NCBI Gene ID: 2324
    neXtProt AC: NX_P35916
    UniProt: P35916

  • Chr Location
    5q35.3; chr5:180601506-180650298 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Flt4 mouse models; 1 with human FLT4 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 6 alleles in 6 genetic backgrounds
    14 phenotypes from multigenic genotypes
    6 images
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a targeted null mutation show growth retardation, vascular abnormalities, severe anemia and die from cardiovascular failure at embryonic day 9.5. Heterozygotes for another mutation show abdominal chylous ascites, abnormal lymphaticvessels, and lymphedema.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14257 NCBI Gene Model | MGI Sequence Detail 43061 C57BL/6J ±  kb
    transcript NM_008029 RefSeq | MGI Sequence Detail 5853 C57BL/6  
    polypeptide P35917 UniProt | EBI | MGI Sequence Detail 1363 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 1
      cDNA 24
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1984, MGD-MRK-9835, MGD-MRK-9839, MGI:2144119, MGI:88402
    References
    more
    • Summaries
      All 260
      Developmental Gene Expression 139
      Diseases 1
      Gene Ontology 17
      Phenotypes 79
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:275413 Broggi MAS, et al., Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients. J Exp Med. 2019 May 6;216(5):1091-1107

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/09/2019
    MGI 6.14
    The Jackson Laboratory