Flnc
Gene Detail

Symbol Name ID

Flnc filamin C, gamma MGI:95557

Synonyms

1110055E19Rik, actin binding protein 280, Fln2

Feature Type

protein coding gene

Genetic Map

Chromosome 6

12.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:29433256-29461849 bp, + strand From VEGA annotation of GRCm38   28594 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37481  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Flnc

Human homologs

Human Homolog		FLNC, filamin C, gamma
NCBI Gene ID		2318
neXtProt AC		NX_Q14315
Human Synonyms		ABP-280, ABP280A, ABPA, ABPL, FLN2, MFM5, MPD4
Human Chr (Location)		7q32-q35; chr7:128470483-128499328 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human FLNC

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a hypomorphic allele display neonatal lethality, respiratory failure, reduced skeletal muscle mass, and abnormal skeletal muscle fiber morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	actin filament-based process, muscle fiber development
Component	actin cytoskeleton, cytoplasm, ...
Function	actin binding, ankyrin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (130)    Tissues (43)    Images (30)
Theiler Stages: 12, 13, 15, 17, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	125
RT-PCR	5

cDNA source data(75)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(78) cDNA(76) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000022425 (Evidence)
Ensembl Gene Model	ENSMUSG00000068699 (Evidence)
Entrez Gene	68794 (Evidence)
UniGene	39046
DFCI	TC1597408, TC1603005, TC1613965
DoTS	DT.491990, DT.94232676, DT.94248062
NIA Mouse Gene Index	U006614
Consensus CDS Project	CCDS39452.1
International Mouse Knockout Project Status	Flnc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022425	VEGA Gene Model | MGI Sequence Detail	28594	C57BL/6J
transcript	OTTMUST00000053613	VEGA | MGI Sequence Detail	9037	Not Applicable
polypeptide	OTTMUSP00000025499	VEGA | MGI Sequence Detail	2737	Not Applicable

All sequences(43) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(104 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001589	Actinin-type, actin-binding, conserved site
InterPro	IPR001715	Calponin homology domain
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR001298	Filamin/ABP280 repeat
InterPro	IPR017868	Filamin/ABP280 repeat-like
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR013783	Immunoglobulin-like fold
Protein Ontology	PR:000007557	filamin-C

References

(Earliest) J:18473 Gariboldi M, et al., Comparative mapping of the actin-binding protein 280 genes in human and mouse. Genomics. 1994 May 15;21(2):428-30
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(41)

Other accession IDs

MGD-MRK-9830, MGI:1916044