About   Help   FAQ
Flnc
Gene Detail
Symbol

Name
ID
Flnc
filamin C, gamma
MGI:95557
Synonyms
1110055E19Rik, actin binding protein 280, Fln2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
12.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:29433256-29461849 bp, + strand
From VEGA annotation of GRCm38

  28594 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37481  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Flnc

Human
homologs
Human Homolog FLNC, filamin C, gamma
NCBI Gene ID 2318
neXtProt AC  NX_Q14315
Human Synonyms  ABP-280, ABP280A, ABPA, ABPL, FLN2, MFM5, MPD4
Human Chr (Location)  7q32-q35; chr7:128830382-128859274 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human FLNC
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a hypomorphic allele display neonatal lethality, respiratory failure, reduced skeletal muscle mass, and abnormal skeletal muscle fiber morphology.
 
Interactions
Flnc interacts with 178 markers (Mir18, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process actin filament-based process, muscle fiber development
Component actin cytoskeleton, cytoplasm, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (130)    Tissues (44)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 125
RT-PCR 5
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) cDNA(76) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022425 (Evidence)
Ensembl Gene ModelENSMUSG00000068699 (Evidence)
Entrez Gene68794 (Evidence)
UniGene39046
DFCITC1603005, TC1597408, TC1613965
DoTSDT.94248062, DT.94232676, DT.491990
NIA Mouse Gene IndexU006614
Consensus CDS ProjectCCDS39452.1
International Mouse Knockout Project StatusFlnc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022425 VEGA Gene Model | MGI Sequence Detail 28594 C57BL/6J ±  kb
transcript OTTMUST00000053613 VEGA | MGI Sequence Detail 9037 Not Applicable 
polypeptide OTTMUSP00000025499 VEGA | MGI Sequence Detail 2737 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001589 Actinin-type, actin-binding, conserved site
InterPro IPR001715 Calponin homology domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR001298 Filamin/ABP280 repeat
InterPro IPR017868 Filamin/ABP280 repeat-like
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000007557 filamin-C
References
(Earliest) J:18473 Gariboldi M, et al., Comparative mapping of the actin-binding protein 280 genes in human and mouse. Genomics. 1994 May 15;21(2):428-30
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(42)
Other
accession IDs
MGD-MRK-9830, MGI:1916044

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory