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Flnc
Gene Detail
Symbol

Name
ID
Flnc
filamin C, gamma
MGI:95557
Synonyms
1110055E19Rik, actin binding protein 280, Fln2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
12.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:29433256-29461849 bp, + strand
From VEGA annotation of GRCm38

  28594 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37481  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FLNC
Gene Tree: Flnc

Human
homologs
FLNC, filamin C, gamma
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2318
neXtProt AC: NX_Q14315

Human Synonyms: ABP-280, ABP280A, ABPA, ABPL, FLN2, MFM5, MPD4

Human Chr (Location): 7q32-q35; chr7:128830429-128859274 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human FLNC

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a hypomorphic allele display neonatal lethality, respiratory failure, reduced skeletal muscle mass, and abnormal skeletal muscle fiber morphology.
 
Interactions
Flnc interacts with 177 markers (Mir18, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process actin filament-based process, muscle fiber development
Component actin cytoskeleton, cytoplasm, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (130)    Tissues (44)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 125
RT-PCR 5
cDNA source data(75)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase flnc ; ZFIN flnca, flncb    NEW 
Molecular
reagents
All nucleic(78) cDNA(76) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022425 (Evidence)
Ensembl Gene Model ENSMUSG00000068699 (Evidence)
Entrez Gene 68794 (Evidence)
UniGene 39046
DFCI TC1597408, TC1603005, TC1613965
DoTS DT.491990, DT.94232676, DT.94248062
NIA Mouse Gene Index U006614
Consensus CDS Project CCDS39452.1, CCDS80503.1
International Mouse Phenotyping Consortium Status Flnc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022425 VEGA Gene Model | MGI Sequence Detail 28594 C57BL/6J ±  kb
transcript OTTMUST00000053613 VEGA | MGI Sequence Detail 9004 Not Applicable 
polypeptide OTTMUSP00000025499 VEGA | MGI Sequence Detail 2726 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(5) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001589 Actinin-type actin-binding domain, conserved site
InterPro IPR001715 Calponin homology domain
InterPro IPR003961 Fibronectin type III
InterPro IPR001298 Filamin/ABP280 repeat
InterPro IPR017868 Filamin/ABP280 repeat-like
InterPro IPR028559 Filamin A/C
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000007557 filamin-C
References
(Earliest) J:18473 Gariboldi M, et al., Comparative mapping of the actin-binding protein 280 genes in human and mouse. Genomics. 1994 May 15;21(2):428-30
(Latest) J:213153 Harms MJ, et al., Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 2014 Apr 1;19(4):593-604
All references(41)
Other
accession IDs
MGD-MRK-9830, MGI:1916044

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory