|
Symbol Name ID |
Flnc
filamin C, gamma MGI:95557 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Weakness of facial musculature |
Abnormal calf musculature morphology |
Distal lower limb muscle weakness |
Intrinsic hand muscle atrophy |
Finger flexor weakness |
Thenar muscle weakness |
Distal upper limb amyotrophy |
Foot dorsiflexor weakness |
Proximal muscle weakness in lower limbs |
Hip flexor weakness |
Distal upper limb muscle weakness |
Difficulty climbing stairs |
Difficulty running |
Difficulty walking |
Muscle weakness |
Fatiguable weakness of proximal limb muscles |
Proximal muscle weakness |
Respiratory insufficiency due to muscle weakness |
Muscle fiber cytoplasmatic inclusion bodies |
Muscle fiber splitting |
Skeletal muscle atrophy |
Distal lower limb amyotrophy |
Myopathy |
Myofibrillar myopathy |
| Disease(s) Associated with FLNC | ||||||||||||||||||||||||
| distal myopathy 4 | ||||||||||||||||||||||||
| myofibrillar myopathy 5 |
| Mouse Phenotypes | muscle phenotype |
abnormal extensor digitorum longus morphology |
abnormal soleus morphology |
abnormal tibialis anterior morphology |
abnormal myogenesis |
abnormal muscle fiber morphology |
abnormal sarcomere morphology |
abnormal Z line morphology |
abnormal skeletal muscle fiber morphology |
increased variability of skeletal muscle fiber size |
centrally nucleated skeletal muscle fibers |
decreased skeletal muscle fiber number |
skeletal muscle fiber degeneration |
abnormal skeletal muscle morphology |
abnormal diaphragm morphology |
abnormal intercostal muscle morphology |
decreased skeletal muscle mass |
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| Availability | Mouse Genotype | |||||||||||||||||
| Flnctm1Lmk/Flnctm1Lmk | ||||||||||||||||||
| Flnctm1.1Rsdf/Flnc+ | * | |||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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