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Flna
Gene Detail
 Symbol
Name
ID
Flna
filamin, alpha
MGI:95556
Synonyms ABP-280, actin-binding protein 280, Dilp2, F730004A14Rik, filamin-1, Fln1, GENA 379
Feature Type protein coding gene
Genetic Map
Chromosome X
37.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
ChrX:74223461-74249820 bp, - strand
From VEGA annotation of GRCm38

  26360 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1119  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Flna

Human
homologs
Human Homolog FLNA, filamin A, alpha
NCBI Gene ID 2316
neXtProt AC  NX_P21333
Human Synonyms  ABP-280, ABPX, CSBS, CVD1, FLN, FLN1, FLN-A, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD
Human Chr (Location)  Xq28; chrX:154348532-154374638 (-)  GRCh38
Disease Associations  (10) Diseases Associated with Human FLNA
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Chemically induced (ENU)(1) Gene trapped(16) Targeted(4)
Incidental mutations (data from APF )
 
Females heterozygous for an X-linked, ENU-induced mutation exhibit dilated pupils and milder cardiac, sternum, and palate defects than males. Hemizygous males are inviable and exhibit incomplete septation of the outflow tract, septal defects, cleft palate and incomplete fusion of the sternum.
 
Human Diseases Modeled Using Mouse Flna (4)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Flna interacts with 499 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process actin crosslink formation, actin cytoskeleton organization, ...
Component actin cytoskeleton, actin filament, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (15)    Tissues (13)    Images (3)
Theiler Stages: 17, 20, 22, 28
Assay TypeResults
RNA in situ 12
Western blot 3
cDNA source data(533)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(545) Genomic(7) cDNA(537) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016503 (Evidence)
Ensembl Gene ModelENSMUSG00000031328 (Evidence)
Entrez Gene192176 (Evidence)
UniGene295533
DFCITC1635032, TC1671621, TC1675382
DoTSDT.101404625, DT.537024
NIA Mouse Gene IndexU039468, U127308
Consensus CDS ProjectCCDS41018.1
International Mouse Knockout Project StatusFlna
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016503 VEGA Gene Model | MGI Sequence Detail 26360 C57BL/6J ±  kb
transcript OTTMUST00000039863 VEGA | MGI Sequence Detail 8312 Not Applicable 
polypeptide OTTMUSP00000017782 VEGA | MGI Sequence Detail 2647 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(6) UniProt(12)
Polymorphisms SNPs within 2kb(87 from dbSNP Build 137)    SNPs within 2kb including multiple locations(117)
Protein-related
information
ResourceIDDescription
InterPro IPR001589 Actinin-type, actin-binding, conserved site
InterPro IPR001715 Calponin homology domain
InterPro IPR001298 Filamin/ABP280 repeat
InterPro IPR017868 Filamin/ABP280 repeat-like
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000007555 filamin-A
References (Earliest) J:18473 Gariboldi M, et al., Comparative mapping of the actin-binding protein 280 genes in human and mouse. Genomics. 1994 May 15;21(2):428-30
(Latest) J:206618 Pinto VI, et al., Filamin A protects cells against force-induced apoptosis by stabilizing talin- and vinculin-containing cell adhesions. FASEB J. 2014 Jan;28(1):453-63
All references(84)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-9829, MGI:1934608, MGI:2444346

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory