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Fli1 Gene Detail
Summary
  • Symbol
    Fli1
  • Name
    Friend leukemia integration 1
  • Synonyms
    EWSR2, Fli-1, Sic1, SIC-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95554
    NCBI Gene: 14247
  • Gene Overview
    MyGene.info: FLI1
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:32422204-32542861 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 17.74 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1243 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95554
 protein coding gene Chr9:32422204-32543432 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034525
 protein coding gene Chr9:30172383-30298664 (-)
A/J MGP_AJ_G0034503
 protein coding gene Chr9:29394881-29519749 (-)
AKR/J MGP_AKRJ_G0034429
 protein coding gene Chr9:30033356-30155308 (-)
BALB/cJ MGP_BALBcJ_G0034494
 protein coding gene Chr9:29288220-29409290 (-)
C3H/HeJ MGP_C3HHeJ_G0034206
 protein coding gene Chr9:30379044-30504399 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035015
 protein coding gene Chr9:31193748-31323027 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031945
 protein coding gene Chr9:28190571-28312230 (-)
CAST/EiJ MGP_CASTEiJ_G0033529
 protein coding gene Chr9:30244065-30364497 (-)
CBA/J MGP_CBAJ_G0034180
 protein coding gene Chr9:32238359-32366537 (-)
DBA/2J MGP_DBA2J_G0034337
 protein coding gene Chr9:29405706-29525591 (-)
FVB/NJ MGP_FVBNJ_G0034280
 protein coding gene Chr9:28810295-28933795 (-)
LP/J MGP_LPJ_G0034423
 protein coding gene Chr9:30386100-30515256 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034324
 protein coding gene Chr9:33850086-33972478 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035035
 protein coding gene Chr9:30024006-30146184 (-)
PWK/PhJ MGP_PWKPhJ_G0033234
 protein coding gene Chr9:29362059-29486766 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033069
 protein coding gene Chr9:30133427-30262544 (-)
WSB/EiJ MGP_WSBEiJ_G0033644
 protein coding gene Chr9:29775463-29897898 (-)



Homology
more
  • Human Ortholog
    FLI1, Fli-1 proto-oncogene, ETS transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FLI1, Fli-1 proto-oncogene, ETS transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDPLT21, EWSR2, SIC-1
  • Links
    NCBI Gene ID: 2313
    neXtProt AC: NX_Q01543
    UniProt: Q01543

  • Chr Location
    11q24.3; chr11:128685263-128813267 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Fli1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 9 alleles in 8 genetic backgrounds
    17 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for most knock-out allele exhibit abnormal hematopoietic and immune systems.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    100
  • cDNA Data
    34
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016087 Ensembl Gene Model | MGI Sequence Detail 120658 C57BL/6J ±  kb
    transcript ENSMUST00000016231 Ensembl | MGI Sequence Detail 3318 Not Applicable  
    polypeptide ENSMUSP00000016231 Ensembl | MGI Sequence Detail 452 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000007553 Friend leukemia integration 1 transcription factor
      (term hierarchy)
    • InterPro Domains
      IPR000418 Ets domain
      IPR035575 Friend leukemia integration 1 transcription factor
      IPR035573 Friend leukemia integration 1 transcription factor, pointed domain
      IPR003118 Pointed domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 14
      cDNA 34
      Primer pair 4
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9824, MGD-MRK-9825
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 27
      Diseases 1
      Gene Ontology 10
      Phenotypes 34
    • Earliest
      J:10321 Ben-David Y, et al., Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1332-6
    • Latest
      J:294088 Bujor AM, et al., Fli1 Downregulation in Scleroderma Myeloid Cells Has Profibrotic and Proinflammatory Effects. Front Immunol. 2020;11:800
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/12/2021
    MGI 6.16     		The Jackson Laboratory