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Fli1
Gene Detail
 Symbol
Name
ID
Fli1
Friend leukemia integration 1
MGI:95554
Synonyms EWSR2, Fli-1, Sic1, SIC-1
Feature Type protein coding gene
Genetic Map
Chromosome 9
17.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr9:32422204-32542861 bp, - strand
From VEGA annotation of GRCm38

  120658 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55624  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor erg
Gene Tree: Fli1

Human
homologs
Human Homolog FLI1, Fli-1 proto-oncogene, ETS transcription factor
NCBI Gene ID 2313
neXtProt AC  NX_Q01543
Human Synonyms  EWSR2, SIC-1
Human Chr (Location)  11q24.1-q24.3; chr11:128686535-128813267 (+)  GRCh38
Alleles
and
phenotypes
All alleles(10) : Gene trapped(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for most knock-out allele exhibit abnormal hematopoietic and immune systems.
 
Human Diseases Modeled Using Mouse Fli1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process blood circulation, cellular process, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (127)    Tissues (93)    Images (19)
Theiler Stages: 13, 15, 17, 19, 21, 22, 23, 25
Assay TypeResults
RNA in situ 115
In situ reporter (knock in) 3
Western blot 3
RT-PCR 6
cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(48) Genomic(14) cDNA(32) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000044678 (Evidence)
Ensembl Gene ModelENSMUSG00000016087 (Evidence)
Entrez Gene14247 (Evidence)
UniGene258908
DFCITC1577491
DoTSDT.110628293, DT.485049
NIA Mouse Gene IndexU030653
Consensus CDS ProjectCCDS40571.1
International Mouse Knockout Project StatusFli1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044678 VEGA Gene Model | MGI Sequence Detail 120658 C57BL/6J ±  kb
transcript OTTMUST00000117512 VEGA | MGI Sequence Detail 3318 Not Applicable 
polypeptide OTTMUSP00000065699 VEGA | MGI Sequence Detail 452 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(8) UniProt(5)
Polymorphisms RFLP(2) : SNPs within 2kb(1220 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR003118 Pointed domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007553 friend leukemia integration 1 transcription factor
References (Earliest) J:10321 Ben-David Y, et al., Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1332-6
(Latest) J:207547 Richard EM, et al., Reducing FLI1 levels in the MRL/lpr lupus mouse model impacts T cell function by modulating glycosphingolipid metabolism. PLoS One. 2013;8(9):e75175
All references(97)
Other
accession IDs
MGD-MRK-9824, MGD-MRK-9825

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory