About   Help   FAQ
Fli1
Gene Detail
Symbol

Name
ID
Fli1
Friend leukemia integration 1
MGI:95554
Synonyms
EWSR2, Fli-1, Sic1, SIC-1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
17.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr9:32422204-32542861 bp, - strand
From VEGA annotation of GRCm38

  120658 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55624  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FLI1
Protein SuperFamily: transcription factor erg
Gene Tree: Fli1

Human
homologs
FLI1, Fli-1 proto-oncogene, ETS transcription factor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2313
neXtProt AC: NX_Q01543

Human Synonyms: EWSR2, SIC-1

Human Chr (Location): 11q24.1-q24.3; chr11:128686535-128813267 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(1) Targeted(10)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for most knock-out allele exhibit abnormal hematopoietic and immune systems.
 
Human Diseases Modeled in Mice Using Fli1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Fli1 interacts with 275 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process blood circulation, cell differentiation, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (127)    Tissues (93)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 115
In situ reporter (knock in) 3
Western blot 3
RT-PCR 6
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FLI1 ; Xenbase fli1 ; ZFIN fli1a, fli1b    NEW 
Molecular
reagents
All nucleic(48) Genomic(14) cDNA(32) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000044678 (Evidence)
Ensembl Gene Model ENSMUSG00000016087 (Evidence)
Entrez Gene 14247 (Evidence)
UniGene 258908
DFCI TC1577491
DoTS DT.110628293, DT.485049
NIA Mouse Gene Index U030653
Consensus CDS Project CCDS40571.1
International Mouse Phenotyping Consortium Status Fli1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044678 VEGA Gene Model | MGI Sequence Detail 120658 C57BL/6J ±  kb
transcript OTTMUST00000117512 VEGA | MGI Sequence Detail 3318 Not Applicable 
polypeptide OTTMUSP00000065699 VEGA | MGI Sequence Detail 452 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(6) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(1220 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR003118 Pointed domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007553 friend leukemia integration 1 transcription factor
References
(Earliest) J:10321 Ben-David Y, et al., Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1332-6
(Latest) J:221094 Carracedo S, et al., Redundant role of protein kinase C delta and epsilon during mouse embryonic development. PLoS One. 2014;9(8):e103686
All references(98)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-9824, MGD-MRK-9825

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory