Fli1
Gene Detail

Symbol Name ID

Fli1 Friend leukemia integration 1 MGI:95554

Synonyms

EWSR2, Fli-1, Sic1, SIC-1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

17.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)

Sequence Map

Chr9:32422208-32541368 bp, - strand From NCBI annotation of GRCm38   119161 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55624  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor erg
Gene Tree: Fli1

Human homologs

Human Homolog		FLI1, Fli-1 proto-oncogene, ETS transcription factor
NCBI Gene ID		2313
neXtProt AC		NX_Q01543
Human Synonyms		EWSR2, SIC-1
Human Chr (Location)		11q24.1-q24.3; chr11:128556430-128683162 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(9) Gene trapped(1)
 

Mice homozygous for most knock-out allele exhibit abnormal hematopoietic and immune systems.

 
Human Diseases Modeled Using Mouse Fli1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	blood circulation, cellular process, ...
Component	nucleus
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (127)    Tissues (93)    Images (19)
Theiler Stages: 13, 15, 17, 19, 21, 22, 23, 25

Assay Type	Results
RNA in situ	115
In situ reporter (knock in)	3
Western blot	3
RT-PCR	6

cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(48) Genomic(14) cDNA(32) Primer pair(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000016087 (Evidence)
Entrez Gene	14247 (Evidence)
UniGene	258908
DFCI	TC1577491
DoTS	DT.110628293, DT.485049
NIA Mouse Gene Index	U030653
Consensus CDS Project	CCDS40571.1
International Mouse Knockout Project Status	Fli1

Sequences

Length	Strain/Species
genomic	14247	NCBI Gene Model | MGI Sequence Detail	119161	C57BL/6J
transcript	NM_008026	RefSeq | MGI Sequence Detail	3087	C57BL/6
polypeptide	P26323	UniProt | EBI | MGI Sequence Detail	452	Not Applicable

All sequences(26) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(2) : SNPs within 2kb(1212 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000418	Ets domain
InterPro	IPR003118	Pointed domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000007553	friend leukemia integration 1 transcription factor

Graphical View of Protein Domain Structure

References

(Earliest) J:10321 Ben-David Y, et al., Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1332-6
(Latest) J:190670 Suzuki E, et al., Fli-1 transcription factor affects glomerulonephritis development by regulating expression of monocyte chemoattractant protein-1 in endothelial cells in the kidney. Clin Immunol. 2012 Dec;145(3):201-8
All references(91)

Other accession IDs

MGD-MRK-9824, MGD-MRK-9825