About   Help   FAQ
Ctgf Gene Detail
Summary
  • Symbol
    Ctgf
  • Name
    connective tissue growth factor
  • Synonyms
    Ccn2, Fisp12, Hcs24, hypertrophic chondrocyte-specific gene product 24
  • Feature Type
    protein coding gene
  • IDs
    MGI:95537
    NCBI Gene: 14219
  • Gene Overview
    MyGene.info: CTGF
Location & Maps
more
  • Sequence Map
    Chr10:24595442-24598683 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3242 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 11.84 cM, cytoband A3-B1
  • Mapping Data
    5 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    CTGF, connective tissue growth factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CTGF, connective tissue growth factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CCN2, HCS24, IGFBP8, NOV2
  • Links
    NCBI Gene ID: 1490
    neXtProt AC: NX_P29279

  • Chr Location
    6q23.1; chr6:131948176-131951378 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    71 phenotypes from 7 alleles in 9 genetic backgrounds
    1 phenotype from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Targeted
    9
  • Genomic Mutations
    1 involving Ctgf
  • Incidental Mutations
Homozygous null mice die at birth from respiratory failure due to axial skeletal defects and pulmonary hypoplasia associated with reduced cell proliferation, enhanced apoptosis and altered pneumocyte maturation. Osteogenesis is impaired due to impaired chondrogenesis and growth plate angiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019709 VEGA Gene Model | MGI Sequence Detail 3242 C57BL/6J ±  kb
transcript OTTMUST00000047191 VEGA | MGI Sequence Detail 2398 Not Applicable  
polypeptide OTTMUSP00000021306 VEGA | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    44 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003172 connective tissue growth factor
  • InterPro Domains
    IPR006207 Cystine knot, C-terminal
    IPR006208 Glycoprotein hormone subunit beta, cystine knot
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR012395 IGFBP-related, CNN
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
    IPR000884 Thrombospondin type-1 (TSP1) repeat
    IPR001007 VWFC domain
Molecular
Reagents
less
  • All nucleic 155
    Genomic 1
    cDNA 149
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9804
References
more
  • Summaries
    All 150
    Developmental Gene Expression 76
    Gene Ontology 16
    Phenotypes 39
  • Earliest
    J:11407 Ryseck RP, et al., Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein. Cell Growth Differ. 1991 May;2(5):225-33
  • Latest
    J:227758 Tasic B, et al., Adult mouse cortical cell taxonomy revealed by single cell transcriptomics. Nat Neurosci. 2016 Jan 4;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory