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Ctgf
Gene Detail
Symbol

Name
ID
Ctgf
connective tissue growth factor
MGI:95537
STS
Synonyms
Ccn2, Fisp12, Hcs24, hypertrophic chondrocyte-specific gene product 24
Feature Type
protein coding gene
Genetic Map
Chromosome 10
11.84 cM, cytoband A3-B1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:24595442-24598683 bp, + strand
From VEGA annotation of GRCm38

  3242 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1431  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: IGFBP-related protein, CNN type
Gene Tree: Ctgf

Human
homologs
Human Homolog CTGF, connective tissue growth factor
NCBI Gene ID 1490
neXtProt AC  NX_P29279
Human Synonyms  CCN2, HCS24, IGFBP8, NOV2
Human Chr (Location)  6q23.1; chr6:131948176-131951378 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die at birth from respiratory failure due to axial skeletal defects and pulmonary hypoplasia associated with reduced cell proliferation, enhanced apoptosis and altered pneumocyte maturation. Osteogenesis is impaired due to impaired chondrogenesis and growth plate angiogenesis.
 
Interactions
Ctgf interacts with 281 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process angiogenesis, cartilage condensation, ...
Component cell cortex, cis-Golgi network, ...
Function fibronectin binding, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (65 records)
Data Summary: Results (529)    Tissues (144)    Images (87)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 512
RT-PCR 17
cDNA source data(144)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(150) Genomic(1) cDNA(147) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019709 (Evidence)
Ensembl Gene ModelENSMUSG00000019997 (Evidence)
Entrez Gene14219 (Evidence)
UniGene390287
DFCITC1574230, TC1592073
DoTSDT.110603324, DT.533980
NIA Mouse Gene IndexU011348
Consensus CDS ProjectCCDS23751.1
International Mouse Knockout Project StatusCtgf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019709 VEGA Gene Model | MGI Sequence Detail 3242 C57BL/6J ±  kb
transcript OTTMUST00000047191 VEGA | MGI Sequence Detail 2398 Not Applicable 
polypeptide OTTMUSP00000021306 VEGA | MGI Sequence Detail 348 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006208 Cystine knot
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR012395 IGFBP-related, CNN
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro IPR000884 Thrombospondin, type 1 repeat
InterPro IPR001007 von Willebrand factor, type C
Protein Ontology PR:000003172 connective tissue growth factor
References
(Earliest) J:11407 Ryseck RP, et al., Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein. Cell Growth Differ. 1991 May;2(5):225-33
(Latest) J:210167 Yang J, et al., Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L786-96
All references(134)
Other
accession IDs
MGD-MRK-9804

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory