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Ctgf Gene Detail
Summary
  • Symbol
    Ctgf
  • Name
    connective tissue growth factor
  • Synonyms
    Ccn2, Fisp12, Hcs24, hypertrophic chondrocyte-specific gene product 24
  • Feature Type
    protein coding gene
  • IDs
    MGI:95537
    NCBI Gene: 14219
  • Gene Overview
    MyGene.info: CTGF
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:24595442-24598683 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3242 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 11.84 cM, cytoband A3-B1
  • Mapping Data
    5 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    CTGF, connective tissue growth factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CTGF, connective tissue growth factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CCN2, HCS24, IGFBP8, NOV2
  • Links
    NCBI Gene ID: 1490
    neXtProt AC: NX_P29279
    UniProt: P29279

  • Chr Location
    6q23.2; chr6:131948176-131951378 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 7 alleles in 9 genetic backgrounds
    4 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die at birth from respiratory failure due to axial skeletal defects and pulmonary hypoplasia associated with reduced cell proliferation, enhanced apoptosis and altered pneumocyte maturation. Osteogenesis is impaired due to impaired chondrogenesis and growth plate angiogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000019709 VEGA Gene Model | MGI Sequence Detail 3242 C57BL/6J ±  kb
    transcript OTTMUST00000047191 VEGA | MGI Sequence Detail 2398 Not Applicable  
    polypeptide OTTMUSP00000021306 VEGA | MGI Sequence Detail 348 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      44 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000003172 connective tissue growth factor
    • InterPro Domains
      IPR006207 Cystine knot, C-terminal
      IPR006208 Glycoprotein hormone subunit beta
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR012395 IGFBP-related, CNN
      IPR000867 Insulin-like growth factor-binding protein, IGFBP
      IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
      IPR001007 VWFC domain
    Molecular
    Reagents
    less
    • All nucleic 157
      Genomic 1
      cDNA 150
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9804
    References
    more
    • Summaries
      All 218
      Developmental Gene Expression 98
      Gene Ontology 17
      Phenotypes 43
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:257228 Li S, et al., Differential expression of transforming growth factor-beta1, connective tissue growth factor, phosphorylated-SMAD2/3 and phosphorylated-ERK1/2 during mouse tooth development. J Mol Histol. 2017 Dec;48(5-6):347-355

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory