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Ccn2 Gene Detail
Summary
  • Symbol
    Ccn2
  • Name
    cellular communication network factor 2
  • Synonyms
    Ccn2, Ctgf, Fisp12, Hcs24, hypertrophic chondrocyte-specific gene product 24
  • Feature Type
    protein coding gene
  • IDs
    MGI:95537
    NCBI Gene: 14219
  • Gene Overview
    MyGene.info: CCN2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:24595442-24598683 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 11.84 cM, cytoband A3-B1
  • Mapping Data
    5 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95537
protein coding gene Chr10:24595442-24598683 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017092
protein coding gene Chr10:22576348-22579589 (+)
A/J MGP_AJ_G0017069
protein coding gene Chr10:21914646-21917887 (+)
AKR/J MGP_AKRJ_G0017029
protein coding gene Chr10:22275588-22278829 (+)
BALB/cJ MGP_BALBcJ_G0017032
protein coding gene Chr10:22011419-22014660 (+)
C3H/HeJ MGP_C3HHeJ_G0016852
protein coding gene Chr10:22483518-22486759 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017490
protein coding gene Chr10:23273404-23276645 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015188
protein coding gene Chr10:20610892-20613012 (+)
CAST/EiJ MGP_CASTEiJ_G0016431
protein coding gene Chr10:22423889-22428687 (+)
CBA/J MGP_CBAJ_G0016826
protein coding gene Chr10:24315971-24319212 (+)
DBA/2J MGP_DBA2J_G0016931
protein coding gene Chr10:21645226-21648769 (+)
FVB/NJ MGP_FVBNJ_G0016926
protein coding gene Chr10:21350913-21354154 (+)
LP/J MGP_LPJ_G0017008
protein coding gene Chr10:22565560-22568801 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016956
protein coding gene Chr10:24437600-24440841 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017526
protein coding gene Chr10:22139856-22143081 (+)
PWK/PhJ MGP_PWKPhJ_G0016213
protein coding gene Chr10:21408827-21430352 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015997
protein coding gene Chr10:21955178-21958824 (+)
WSB/EiJ MGP_WSBEiJ_G0016494
protein coding gene Chr10:22259871-22263988 (+)



Homology
more
  • Human Ortholog
    CCN2, cellular communication network factor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CCN2, cellular communication network factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTGF, HCS24, IGFBP8, NOV2
  • Links
    NCBI Gene ID: 1490
    neXtProt AC: NX_P29279
    UniProt: P29279

  • Chr Location
    6q23.2; chr6:131948176-131951378 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 7 alleles in 10 genetic backgrounds
    3 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice die at birth from respiratory failure due to axial skeletal defects and pulmonary hypoplasia associated with reduced cell proliferation, enhanced apoptosis and altered pneumocyte maturation. Osteogenesis is impaired due to impaired chondrogenesis and growth plate angiogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14219 NCBI Gene Model | MGI Sequence Detail 3242 C57BL/6J ±  kb
    transcript NM_010217 RefSeq | MGI Sequence Detail 2418 C57BL/6  
    polypeptide P29268 UniProt | EBI | MGI Sequence Detail 348 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000003172 connective tissue growth factor
    • InterPro Domains
      IPR006207 Cystine knot, C-terminal
      IPR006208 Glycoprotein hormone subunit beta
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR012395 IGFBP-related, CNN
      IPR000867 Insulin-like growth factor-binding protein, IGFBP
      IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
      IPR001007 VWFC domain
    Molecular
    Reagents
    less
    • All nucleic 159
      Genomic 1
      cDNA 151
      Primer pair 6
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9804
    References
    more
    • Summaries
      All 236
      Developmental Gene Expression 109
      Gene Ontology 17
      Phenotypes 46
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:273437 Yu W, et al., VGLL4 plays a critical role in heart valve development and homeostasis. PLoS Genet. 2019 Feb;15(2):e1007977

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    08/13/2019
    MGI 6.14
    The Jackson Laboratory