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Fh1 Gene Detail
Summary
  • Symbol
    Fh1
  • Name
    fumarate hydratase 1
  • Synonyms
    fumarase
  • Feature Type
    protein coding gene
  • IDs
    MGI:95530
    NCBI Gene: 14194
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:175600374-175625635 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25262 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 81.58 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FH, fumarate hydratase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FH, fumarate hydratase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FMRD, HLRCC, LRCC, MCL, MCUL1
  • Links
    NCBI Gene ID: 2271
    neXtProt AC: NX_P07954
    UniProt: P07954

  • Chr Location
    1q43; chr1:241497557-241519785 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele fail to develop past the egg-cylinder stage and die at E6.0.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000025588 VEGA Gene Model | MGI Sequence Detail 25262 C57BL/6J ±  kb
    transcript OTTMUST00000062946 VEGA | MGI Sequence Detail 2636 Not Applicable  
    polypeptide OTTMUSP00000031090 VEGA | MGI Sequence Detail 507 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      237 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 119
      cDNA 117
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-9792, MGD-MRK-9793
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:44165 Fu X, et al., E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol. 1997 Mar;17(3):1503-12
    • Latest
      J:250512 Li J, et al., CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. Database (Oxford). 2017;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory