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Fh1
Gene Detail
 Symbol
Name
ID
Fh1
fumarate hydratase 1
MGI:95530
Synonyms fumarase
Feature Type protein coding gene
Genetic Map
Chromosome 1
81.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:175600374-175625635 bp, - strand
From VEGA annotation of GRCm38

  25262 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:115  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: fumarate hydratase
Gene Tree: Fh1

Human
homologs
Human Homolog FH, fumarate hydratase
NCBI Gene ID 2271
neXtProt AC  NX_P07954
Human Synonyms  HLRCC, LRCC, MCL, MCUL1
Human Chr (Location)  1q42.1; chr1:241497557-241519785 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FH
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a knock-out allele fail to develop past the egg-cylinder stage and die at E6.0.
 
Interactions
Fh1 interacts with 189 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process fumarate metabolic process, homeostasis of number of cells within a tissue, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function catalytic activity, fumarate hydratase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (152)    Tissues (117)    Images (39)
Theiler Stages: 10, 18, 19, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 134
Northern blot 12
RT-PCR 6
cDNA source data(116)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(118) cDNA(116) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000025588 (Evidence)
Ensembl Gene ModelENSMUSG00000026526 (Evidence)
Entrez Gene14194 (Evidence)
UniGene41502
DFCITC1573079, TC1628468
DoTSDT.110933834, DT.493585
NIA Mouse Gene IndexU022105
EC4.2.1.2
Consensus CDS ProjectCCDS15547.1
International Mouse Knockout Project StatusFh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025588 VEGA Gene Model | MGI Sequence Detail 25262 C57BL/6J ±  kb
transcript OTTMUST00000062946 VEGA | MGI Sequence Detail 2636 Not Applicable 
polypeptide OTTMUSP00000031090 VEGA | MGI Sequence Detail 507 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(237 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018951 Fumarase C, C-terminal
InterPro IPR024083 Fumarase/histidase, N-terminal
InterPro IPR005677 Fumarate hydratase, class II
InterPro IPR000362 Fumarate lyase
InterPro IPR020557 Fumarate lyase, conserved site
InterPro IPR022761 Fumarate lyase, N-terminal
InterPro IPR008948 L-Aspartase-like
Protein Ontology PR:000007511 fumarate hydratase, mitochondrial
References (Earliest) J:44165 Fu X, et al., E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol. 1997 Mar;17(3):1503-12
(Latest) J:198486 Adam J, et al., A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia. Cell Rep. 2013 May 30;3(5):1440-8
All references(49)
Other
accession IDs
MGD-MRK-9792, MGD-MRK-9793

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory