Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables fumarate hydratase activity. Involved in several processes, including positive regulation of cold-induced thermogenesis; regulation of arginine metabolic process; and tricarboxylic acid cycle. Acts upstream of or within homeostasis of number of cells within a tissue. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase).