GO Annotations Graph

• Symbol: Fh1
• Name: fumarate hydratase 1
• ID: MGI:95530

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0004333	fumarate hydratase activity	ISO	J:164563
Molecular Function	GO:0004333	fumarate hydratase activity	ISO	J:164563
Molecular Function	GO:0004333	fumarate hydratase activity	IMP	J:198486
Molecular Function	GO:0004333	fumarate hydratase activity	ISO	J:155856
Molecular Function	GO:0004333	fumarate hydratase activity	IBA	J:265628
Molecular Function	GO:0004333	fumarate hydratase activity	IMP	J:163619
Molecular Function	GO:0042393	histone binding	ISO	J:164563
Molecular Function	GO:0016829	lyase activity	IEA	J:60000
Molecular Function	GO:0016829	lyase activity	IEA	J:72247
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	IDA	J:330411
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Cellular Component	GO:0045239	tricarboxylic acid cycle enzyme complex	IEA	J:72247
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006106	fumarate metabolic process	ISO	J:155856
Biological Process	GO:0006106	fumarate metabolic process	IMP	J:198486
Biological Process	GO:0006106	fumarate metabolic process	ISO	J:164563
Biological Process	GO:0006106	fumarate metabolic process	ISO	J:164563
Biological Process	GO:0006106	fumarate metabolic process	IBA	J:265628
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	IMP	J:120969
Biological Process	GO:0006108	malate metabolic process	ISO	J:155856
Biological Process	GO:0006108	malate metabolic process	ISO	J:164563
Biological Process	GO:0006108	malate metabolic process	IBA	J:265628
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:246945
Biological Process	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	ISO	J:164563
Biological Process	GO:0000821	regulation of arginine metabolic process	IMP	J:198486
Biological Process	GO:0006099	tricarboxylic acid cycle	ISO	J:155856
Biological Process	GO:0006099	tricarboxylic acid cycle	IBA	J:265628
Biological Process	GO:0006099	tricarboxylic acid cycle	IMP	J:182673
Biological Process	GO:0000050	urea cycle	IMP	J:198486