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Fgf5 Gene Detail
Summary
  • Symbol
    Fgf5
  • Name
    fibroblast growth factor 5
  • Synonyms
    Fgf-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:95519
    NCBI Gene: 14176
  • Gene Overview
    MyGene.info: FGF5
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:98254184-98277030 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 47.77 cM, cytoband E1-F
  • Mapping Data
    27 experiments
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95519
protein coding gene Chr5:98254184-98277033 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029773
protein coding gene Chr5:99605143-99632376 (+)
A/J MGP_AJ_G0029739
protein coding gene Chr5:95914456-95938318 (+)
AKR/J MGP_AKRJ_G0029685
protein coding gene Chr5:99093546-99116241 (+)
BALB/cJ MGP_BALBcJ_G0029749
protein coding gene Chr5:96926746-96951730 (+)
C3H/HeJ MGP_C3HHeJ_G0029472
protein coding gene Chr5:99432809-99461640 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030204
protein coding gene Chr5:103787764-103814810 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027439
protein coding gene Chr5:91210539-91232964 (+)
CAST/EiJ MGP_CASTEiJ_G0028883
protein coding gene Chr5:98043699-98070900 (+)
CBA/J MGP_CBAJ_G0029442
protein coding gene Chr5:107362394-107391458 (+)
DBA/2J MGP_DBA2J_G0029586
protein coding gene Chr5:96109496-96132519 (+)
FVB/NJ MGP_FVBNJ_G0029545
protein coding gene Chr5:94924811-94950019 (+)
LP/J MGP_LPJ_G0029674
protein coding gene Chr5:100210670-100237446 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029574
protein coding gene Chr5:112441809-112467358 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030237
protein coding gene Chr5:98531076-98557148 (+)
PWK/PhJ MGP_PWKPhJ_G0028601
protein coding gene Chr5:94506947-94530722 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028436
protein coding gene Chr5:96203021-96225835 (+)
WSB/EiJ MGP_WSBEiJ_G0028961
protein coding gene Chr5:98863187-98890611 (+)



Homology
more
  • Human Ortholog
    FGF5, fibroblast growth factor 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FGF5, fibroblast growth factor 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HBGF-5, Smag-82, TCMGLY
  • Links
    NCBI Gene ID: 2250
    neXtProt AC: NX_P12034
    UniProt: P12034

  • Chr Location
    4q21.21; chr4:80266588-80291017 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 6 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene result in significantly longer pelage hair.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029337 Ensembl Gene Model | MGI Sequence Detail 22847 C57BL/6J ±  kb
    transcript ENSMUST00000031280 Ensembl | MGI Sequence Detail 2501 Not Applicable  
    polypeptide ENSMUSP00000031280 Ensembl | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 5
      cDNA 22
      Primer pair 9
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10212, MGD-MRK-9764, MGD-MRK-9770
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 53
      Gene Ontology 6
      Phenotypes 26
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:263987 Dobreva MP, et al., Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling. Development. 2018 Jul 2;145(13)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    01/15/2019
    MGI 6.13
    The Jackson Laboratory