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Fgf4
Gene Detail
 Symbol
Name
ID
Fgf4
fibroblast growth factor 4
MGI:95518
Synonyms Fgf-4, Fgfk, Hst1, Hstf-1, kFGF
Feature Type protein coding gene
Genetic Map
Chromosome 7
88.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:144861386-144865243 bp, + strand
From NCBI annotation of GRCm38

  3858 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1522  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: fibroblast growth factor
Gene Tree: Fgf4

Human
homologs
Human Homolog FGF4, fibroblast growth factor 4
NCBI Gene ID 2249
neXtProt AC  NX_P08620
Human Synonyms  HBGF-4, HST, HST-1, HSTF1, KFGF, K-FGF
Human Chr (Location)  11q13.3; chr11:69762363-69775403 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(23) Targeted(8)
 
Homozygotes for targeted null mutations die shortly after implantation and mutant embryos cultured in vitro exhibit impaired proliferation of the inner cell mass. Conditional mutations show normal limb development.
 
Interactions
Fgf4 interacts with 264 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process apoptotic process involved in morphogenesis, cartilage condensation, ...
Component cytosol, extracellular region, ...
Function fibroblast growth factor receptor binding, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (248 records)
Data Summary: Results (567)    Tissues (329)    Images (164)
Theiler Stages: 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 467
Northern blot 26
RT-PCR 72
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) Genomic(10) cDNA(28) Primer pair(9) Other(23)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000050917 (Evidence)
Entrez Gene14175 (Evidence)
UniGene4956
DFCITC1588591
DoTSDT.91334532
NIA Mouse Gene IndexU009008
Consensus CDS ProjectCCDS22052.1
International Mouse Knockout Project StatusFgf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14175 NCBI Gene Model | MGI Sequence Detail 3858 C57BL/6J ±  kb
transcript NM_010202 RefSeq | MGI Sequence Detail 3030 C57BL/6 
polypeptide P11403 UniProt | EBI | MGI Sequence Detail 202 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007495 fibroblast growth factor 4
Graphical View of Protein Domain Structure
References (Earliest) J:29168 Sakamoto H, et al., Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3997-4001
(Latest) J:208289 Ohnishi Y, et al., Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages. Nat Cell Biol. 2014 Jan;16(1):27-37
All references(346)
Other
accession IDs
MGD-MRK-10987, MGD-MRK-9763, MGD-MRK-9769, MGD-MRK-9775

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory