Fgf4 MGI Mouse Gene Detail - MGI:95518 - fibroblast growth factor 4

Symbol

Fgf4
Name

fibroblast growth factor 4
Synonyms

Fgf-4, Fgfk, Hst1, Hstf-1, kFGF

Feature Type

protein coding gene
IDs

MGI:95518
NCBI Gene: 14175
Alliance

genome feature page
Transcription Start Sites

1 TSS
Regulated by

Rr627, Rr629, Rr105 (3 regulatory regions)

Sequence Map

Chr7:144415123-144418982 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 88.88 cM
Mapping Data

5 experiments

SNPs within 2kb

114 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95518	protein coding gene	Chr7:144401104-144418982 (+)
129S1/SvImJ	ENSMUSG00200045996	protein coding gene	Chr7:130965711-130983581 (+)
A/J	ENSMUSG00195001737	protein coding gene	Chr7:135449344-135467219 (+)
AKR/J	ENSMUSG00220033032	protein coding gene	Chr7:128926329-128944270 (+)
BALB/cJ	ENSMUSG00180000887	protein coding gene	Chr7:132139176-132157116 (+)
C3H/HeJ	ENSMUSG00175003772	protein coding gene	Chr7:132870386-132888259 (+)
C57BL/6NJ	ENSMUSG00215000095	protein coding gene	Chr7:132136510-132154383 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030758	protein coding gene	Chr7:147039240-147043034 (+)
CAST/EiJ	ENSTCUG00005002781	protein coding gene	Chr7:135465523-135483408 (+)
CBA/J	ENSMUSG00210003546	protein coding gene	Chr7:132627876-132645746 (+)
DBA/2J	ENSMUSG00185014343	protein coding gene	Chr7:136906690-136924567 (+)
FVB/NJ	ENSMUSG00205001910	protein coding gene	Chr7:132534661-132552548 (+)
JF1/MsJ	ENSUMUG00000001878	protein coding gene	Chr7:141934993-141952828 (+)
LP/J	ENSMUSG00230007348	protein coding gene	Chr7:143068140-143086010 (+)
NOD/ShiLtJ	ENSMUSG00190003893	protein coding gene	Chr7:132735421-132753280 (+)
NZO/HlLtJ	ENSMUSG00225021081	protein coding gene	Chr7:141278747-141296609 (+)
PWK/PhJ	ENSLUMG00010037388	protein coding gene	Chr7:131104537-131122296 (+)
SPRET/EiJ	ENSMSPG00010001006	protein coding gene	Chr7:132670376-132688396 (+)
WSB/EiJ	ENSIUOG00005000898	protein coding gene	Chr7:133531246-133548963 (+)

Human Ortholog

FGF4, fibroblast growth factor 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FGF4, fibroblast growth factor 4
Synonyms

FGF-4, HBGF-4, HST, HST-1, HSTF-1, HSTF1, K-FGF, KFGF, SRTD22
Links

HGNC:3682

NCBI Gene ID: 2249

UniProt: P08620
Chr Location

11q13.3; chr11:69771022-69775341 (-) GRCh38

MGI Vertebrate Homology

Fgf4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FGF4
Gene Tree

Fgf4

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References

1 with disease annotations

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Phenotype Summary

24 phenotypes from 9 alleles in 5 genetic backgrounds
16 phenotypes from multigenic genotypes
48 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Endonuclease-mediated

4
Gene trapped

21
Spontaneous

1
Targeted

9
Transgenic

1
Genomic Mutations

1 involving Fgf4
Incidental Mutations

CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a knock-out allele undergo implantation but degenerate shortly thereafter. In vitro, cultured embryos show severely impaired proliferation of the inner cell mass.

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All GO Annotations

39
GO References

20

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1573
Tissues

447
cDNA Data

32
Literature Summary

322

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FGF4

Xenbase fgf4

ZFIN fgf4

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS22052.1

Ensembl

ENSMUSG00000050917 (Evidence)
NCBI Gene

14175

			Length	Strain/Species	Flank
genomic	14175	NCBI Gene Model \| MGI Sequence Detail	3860	C57BL/6J	± kb
transcript	NM_010202	RefSeq \| MGI Sequence Detail	3032	ZRU/MplStud
polypeptide	P11403	UniProt \| EBI \| MGI Sequence Detail	202	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007495 fibroblast growth factor 4

(term hierarchy)
InterPro Domains

IPR008996 Cytokine IL1/FGF

IPR002209 Fibroblast growth factor family
GlyGen

P11403 1 site

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All nucleic 118

Genomic 12

cDNA 34

Primer pair 18

Other 54

Antibodies 3

Microarray probesets 6

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MGD-MRK-10987, MGD-MRK-9763, MGD-MRK-9769, MGD-MRK-9775

Summaries

All 484

Developmental Gene Expression 322

Diseases 1

Gene Ontology 20

Phenotypes 48
Earliest

J:8618 Theiler K, et al., Low set ears (Lse), a new mutation of the house mouse. Anat Embryol (Berl). 1986;175(2):241-6
Latest

J:389174 Li F, et al., NFATC1 dysfunction-triggered MSC senescence induces tooth aging amenable to senolytic therapy. Stem Cell Reports. 2026 Jun 9;21(6):102925

Fgf4 expression regulated by:

Feature	Feature Type	Location	Reference
Rr627, regulatory region 627	insulator	Chr7:144329467-144353354	J:361944
Rr629, regulatory region 629	enhancer	Chr7:144441251-144449797	J:361944
Rr105, regulatory region 105	enhancer	Chr7, Syntenic	J:92206

TSS for Fgf4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70358	Chr7:144415115-144415132 (+)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24