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Fgf4 Gene Detail
Summary
  • Symbol
    Fgf4
  • Name
    fibroblast growth factor 4
  • Synonyms
    Fgf-4, Fgfk, Hst1, Hstf-1, kFGF
  • Feature Type
    protein coding gene
  • IDs
    MGI:95518
    NCBI Gene: 14175
  • Gene Overview
    MyGene.info: FGF4
Location & Maps
more
  • Sequence Map
    Chr7:144847367-144865243 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17877 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.88 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FGF4, fibroblast growth factor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FGF4, fibroblast growth factor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HBGF-4, HST, HST-1, HSTF1, KFGF, K-FGF
  • Links
    NCBI Gene ID: 2249
    neXtProt AC: NX_P08620

  • Chr Location
    11q13.3; chr11:69759043-69775403 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 8 alleles in 4 genetic backgrounds
    9 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Gene trapped
    23
  • Targeted
    8
  • Transgenic
    1
  • Incidental Mutations
Homozygotes for targeted null mutations die shortly after implantation and mutant embryos cultured in vitro exhibit impaired proliferation of the inner cell mass. Conditional mutations show normal limb development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059887 VEGA Gene Model | MGI Sequence Detail 17877 C57BL/6J ±  kb
transcript OTTMUST00000146736 VEGA | MGI Sequence Detail 3030 Not Applicable  
polypeptide OTTMUSP00000076349 VEGA | MGI Sequence Detail 202 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    104 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 77
    Genomic 10
    cDNA 30
    Primer pair 10
    Other 27

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-10987, MGD-MRK-9763, MGD-MRK-9769, MGD-MRK-9775
References
more
  • Summaries
    All 361
    Developmental Gene Expression 271
    Gene Ontology 16
    Phenotypes 31
  • Earliest
    J:29168 Sakamoto H, et al., Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3997-4001
  • Latest
    J:233640 Kyrylkova K, et al., BCL11B regulates sutural patency in the mouse craniofacial skeleton. Dev Biol. 2016 Jul 15;415(2):251-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory