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Fgf3
Gene Detail
Symbol

Name
ID
Fgf3
fibroblast growth factor 3
MGI:95517
STS
Synonyms
Fgf-3, Int-2, Int-P
Feature Type
protein coding gene
Genetic Map
Chromosome 7
88.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(38)
Sequence Map
Chr7:144838083-144844436 bp, + strand
From VEGA annotation of GRCm38

  6354 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3841  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FGF3
Protein SuperFamily: fibroblast growth factor
Gene Tree: Fgf3

Human
homologs
FGF3, fibroblast growth factor 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2248
neXtProt AC: NX_P11487

Human Synonyms: HBGF-3, INT2

Human Chr (Location): 11q13; chr11:69809968-69819424 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FGF3

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(1) Targeted(10)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions of this gene have short, thickened and curved tails. Otic vesicles are somewhat smaller than normal. Mice with some alleles apparently display more severe phenotypes.
 
Interactions
Fgf3 interacts with 201 markers (Mir1a-1, Mir1a-2, Mir22, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (124 records)
Data Summary: Results (441)    Tissues (268)    Images (98)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 328
In situ reporter (knock in) 6
Northern blot 32
RT-PCR 75
cDNA source data(28)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA FGF3 ; Xenbase fgf3 ; ZFIN fgf3    NEW 
Molecular
reagents
All nucleic(112) Genomic(52) cDNA(30) Primer pair(12) Other(18)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000031027 (Evidence)
Ensembl Gene Model ENSMUSG00000031074 (Evidence)
Entrez Gene 14174 (Evidence)
UniGene 4947
DFCI TC1602691, TC1632432, TC1689739
DoTS DT.55252464
NIA Mouse Gene Index U100200
Consensus CDS Project CCDS22051.1
International Mouse Phenotyping Consortium Status Fgf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031027 VEGA Gene Model | MGI Sequence Detail 6354 C57BL/6J ±  kb
transcript OTTMUST00000076860 VEGA | MGI Sequence Detail 2299 Not Applicable 
polypeptide OTTMUSP00000040521 VEGA | MGI Sequence Detail 245 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(10) UniProt(3)
Polymorphisms
All PCR and RFLP(17) : PCR(7) RFLP(10) SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007494 fibroblast growth factor 3
References
(Earliest) J:7351 Peters G, et al., Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes. Mol Cell Biol. 1984 Feb;4(2):375-8
(Latest) J:219394 Boroviak T, et al., The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
All references(230)
Other
accession IDs
MGD-MRK-11419, MGD-MRK-11426, MGD-MRK-9762, MGD-MRK-9768

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory