Fgf3
Gene Detail

Symbol Name ID

Fgf3 fibroblast growth factor 3 MGI:95517

STS

D7Nds4

Synonyms

Fgf-3, Int-2, Int-P

Feature Type

protein coding gene

Genetic Map

Chromosome 7

88.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(38)

Sequence Map

Chr7:144838083-144844436 bp, + strand From VEGA annotation of GRCm38   6354 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3841  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: fibroblast growth factor
Gene Tree: Fgf3

Human homologs

Human Homolog		FGF3, fibroblast growth factor 3
NCBI Gene ID		2248
neXtProt AC		NX_P11487
Human Synonyms		HBGF-3, INT2
Human Chr (Location)		11q13; chr11:69624736-69634192 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FGF3

Alleles and phenotypes

All alleles(11) : Targeted(10) Gene trapped(1)
 

Mice homozygous for disruptions of this gene have short, thickened and curved tails. Otic vesicles are somewhat smaller than normal. Mice with some alleles apparently display more severe phenotypes.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	cell differentiation, fibroblast growth factor receptor signaling pathway, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	growth factor activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (118 records)
Data Summary: Results (430)    Tissues (263)    Images (92)
Theiler Stages: 2, 3, 5, 6, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	317
In situ reporter (knock in)	6
Northern blot	32
RT-PCR	75

cDNA source data(28)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(111) Genomic(52) cDNA(30) Primer pair(12) Other(17)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000031027 (Evidence)
Ensembl Gene Model	ENSMUSG00000031074 (Evidence)
Entrez Gene	14174 (Evidence)
UniGene	4947
DFCI	TC1602691, TC1632432, TC1689739
DoTS	DT.55252464
NIA Mouse Gene Index	U100200
Consensus CDS Project	CCDS22051.1
International Mouse Knockout Project Status	Fgf3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031027	VEGA Gene Model | MGI Sequence Detail	6354	C57BL/6J
transcript	OTTMUST00000076860	VEGA | MGI Sequence Detail	2299	Not Applicable
polypeptide	OTTMUSP00000040521	VEGA | MGI Sequence Detail	245	Not Applicable

All sequences(31) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(17) : PCR(7) RFLP(10) SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008996	Cytokine, IL-1-like
InterPro	IPR002209	Heparin-binding growth factor/Fibroblast growth factor
InterPro	IPR002348	Interleukin 1/heparin-binding growth factor
Protein Ontology	PR:000007494	INT-2 proto-oncogene protein

References

(Earliest) J:7351 Peters G, et al., Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes. Mol Cell Biol. 1984 Feb;4(2):375-8
(Latest) J:194132 Vendrell V, et al., Roles of Wnt8a during formation and patterning of the mouse inner ear. Mech Dev. 2013 Feb;130(2-3):160-8
All references(229)

Other accession IDs

MGD-MRK-11419, MGD-MRK-11426, MGD-MRK-9762, MGD-MRK-9768