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Fgf3
Gene Detail
 Symbol
Name
ID
Fgf3
fibroblast growth factor 3
MGI:95517
STS D7Nds4
Synonyms Fgf-3, Int-2, Int-P
Feature Type protein coding gene
Genetic Map
Chromosome 7
88.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(38)
Sequence Map
Chr7:144838083-144844436 bp, + strand
From VEGA annotation of GRCm38

  6354 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3841  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: fibroblast growth factor
Gene Tree: Fgf3

Human
homologs
Human Homolog FGF3, fibroblast growth factor 3
NCBI Gene ID 2248
neXtProt AC  NX_P11487
Human Synonyms  HBGF-3, INT2
Human Chr (Location)  11q13; chr11:69809968-69819424 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FGF3
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene have short, thickened and curved tails. Otic vesicles are somewhat smaller than normal. Mice with some alleles apparently display more severe phenotypes.
 
Interactions
Fgf3 interacts with 201 markers (Mir1a-1, Mir1a-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cell differentiation, fibroblast growth factor receptor signaling pathway, ...
Component cytoplasm, endoplasmic reticulum, ...
Function fibroblast growth factor receptor binding, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (121 records)
Data Summary: Results (441)    Tissues (264)    Images (98)
Theiler Stages: 2, 3, 5, 6, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 328
In situ reporter (knock in) 6
Northern blot 32
RT-PCR 75
cDNA source data(28)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(112) Genomic(52) cDNA(30) Primer pair(12) Other(18)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000031027 (Evidence)
Ensembl Gene ModelENSMUSG00000031074 (Evidence)
Entrez Gene14174 (Evidence)
UniGene4947
DFCITC1602691, TC1632432, TC1689739
DoTSDT.55252464
NIA Mouse Gene IndexU100200
Consensus CDS ProjectCCDS22051.1
International Mouse Knockout Project StatusFgf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031027 VEGA Gene Model | MGI Sequence Detail 6354 C57BL/6J ±  kb
transcript OTTMUST00000076860 VEGA | MGI Sequence Detail 2299 Not Applicable 
polypeptide OTTMUSP00000040521 VEGA | MGI Sequence Detail 245 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(8) UniProt(3)
Polymorphisms All PCR and RFLP(17) : PCR(7) RFLP(10) SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007494 fibroblast growth factor 3
References (Earliest) J:7351 Peters G, et al., Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes. Mol Cell Biol. 1984 Feb;4(2):375-8
(Latest) J:202909 Mansour SL, et al., Genetic rescue of Muenke syndrome model hearing loss reveals prolonged FGF-dependent plasticity in cochlear supporting cell fates. Genes Dev. 2013 Nov 1;27(21):2320-31
All references(232)
Other
accession IDs
MGD-MRK-11419, MGD-MRK-11426, MGD-MRK-9762, MGD-MRK-9768

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory