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Fgf3 Gene Detail
Summary
  • Symbol
    Fgf3
  • Name
    fibroblast growth factor 3
  • Synonyms
    Fgf-3, Int-2, Int-P
  • Feature Type
    protein coding gene
  • IDs
    MGI:95517
    NCBI Gene: 14174
  • Gene Overview
    MyGene.info: FGF3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:144838083-144844436 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6354 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.85 cM
  • Mapping Data
    38 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    FGF3, fibroblast growth factor 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FGF3, fibroblast growth factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HBGF-3, INT2
  • Links
    NCBI Gene ID: 2248
    neXtProt AC: NX_P11487
    UniProt: P11487

  • Chr Location
    11q13.3; chr11:69809968-69819424 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    56 phenotypes from 7 alleles in 8 genetic backgrounds
    17 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene have short, thickened and curved tails. Otic vesicles are somewhat smaller than normal. Mice with some alleles apparently display more severe phenotypes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031027 VEGA Gene Model | MGI Sequence Detail 6354 C57BL/6J ±  kb
    transcript OTTMUST00000076860 VEGA | MGI Sequence Detail 2299 Not Applicable  
    polypeptide OTTMUSP00000040521 VEGA | MGI Sequence Detail 245 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      52 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR008996 Cytokine IL1/FGF
      IPR028232 Fibroblast growth factor 3
      IPR002209 Fibroblast growth factor family
    Molecular
    Reagents
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    • All nucleic 115
      Genomic 52
      cDNA 31
      Primer pair 13
      Other 19

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11419, MGD-MRK-11426, MGD-MRK-9762, MGD-MRK-9768
    References
    more
    • Summaries
      All 266
      Developmental Gene Expression 147
      Gene Ontology 13
      Phenotypes 34
    • Earliest
      J:7351 Peters G, et al., Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes. Mol Cell Biol. 1984 Feb;4(2):375-8
    • Latest
      J:258789 Jarvinen E, et al., Mesenchymal Wnt/beta-catenin signaling limits tooth number. Development. 2018 Feb 21;145(4)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory