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Fgf1
Gene Detail
 Symbol
Name
ID
Fgf1
fibroblast growth factor 1
MGI:95515
Synonyms Fgf-1, Fgfa, fibroblast growth factor 1 (acidic)
Feature Type protein coding gene
Genetic Map
Chromosome 18
20.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr18:38838673-38929404 bp, - strand
From VEGA annotation of GRCm38

  90732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:625  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: fibroblast growth factor
Gene Tree: Fgf1

Human
homologs
Human Homolog FGF1, fibroblast growth factor 1 (acidic)
NCBI Gene ID 2246
neXtProt AC  NX_P05230
Human Synonyms  AFGF, ECGF, ECGFA, ECGFB, ECGF-beta, FGF-1, FGFA, FGF-alpha, GLIO703, HBGF1, HBGF-1
Human Chr (Location)  5q31; chr5:142592178-142698070 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(58) : Gene trapped(54) Targeted(4)
 
Mice homozygous for a knock-out allele are viable, breed and develop normally, and exhibit normal brain structure and normal rates of wound healing.
 
Interactions
Fgf1 interacts with 339 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process angiogenesis, branch elongation involved in ureteric bud branching, ...
Component cytoplasm, cytosol, ...
Function fibroblast growth factor receptor binding, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (56 records)
Data Summary: Results (438)    Tissues (258)    Images (60)
Theiler Stages: 2, 3, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 310
Northern blot 35
RT-PCR 93
cDNA source data(43)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(71) Genomic(12) cDNA(48) Primer pair(10) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000020317 (Evidence)
Ensembl Gene ModelENSMUSG00000036585 (Evidence)
Entrez Gene14164 (Evidence)
UniGene241282
DFCITC1582787, TC1693688
DoTSDT.532392, DT.99788289, DT.99841324
NIA Mouse Gene IndexU038363
Consensus CDS ProjectCCDS29204.1
International Mouse Knockout Project StatusFgf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020317 VEGA Gene Model | MGI Sequence Detail 90732 C57BL/6J ±  kb
transcript OTTMUST00000048206 VEGA | MGI Sequence Detail 3981 Not Applicable 
polypeptide OTTMUSP00000022029 VEGA | MGI Sequence Detail 155 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(20) UniProt(7)
Polymorphisms RFLP(6) : SNPs within 2kb(928 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007479 fibroblast growth factor 1
References (Earliest) J:13138 Roberts E, A new mutation in the house mouse (Mus musculus). Science. 1931;74:569
(Latest) J:196001 Yu H, et al., Deletion of STK40 protein in mice causes respiratory failure and death at birth. J Biol Chem. 2013 Feb 22;288(8):5342-52
All references(156)
Other
accession IDs
MGD-MRK-9760, MGD-MRK-9766, MGD-MRK-9773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory