About   Help   FAQ
Fgf1 Gene Detail
Summary
  • Symbol
    Fgf1
  • Name
    fibroblast growth factor 1
  • Synonyms
    Fgf-1, Fgfa, fibroblast growth factor 1 (acidic)
  • Feature Type
    protein coding gene
  • IDs
    MGI:95515
    NCBI Gene: 14164
  • Gene Overview
    MyGene.info: FGF1
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:38838673-38929472 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 20.74 cM
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    917 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95515
protein coding gene Chr18:38838672-38929480 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024367
protein coding gene Chr18:37339191-37443797 (-)
A/J MGP_AJ_G0024334
protein coding gene Chr18:36034428-36124587 (-)
AKR/J MGP_AKRJ_G0024303
protein coding gene Chr18:37018679-37109972 (-)
BALB/cJ MGP_BALBcJ_G0024334
protein coding gene Chr18:36110191-36192247 (-)
C3H/HeJ MGP_C3HHeJ_G0024100
protein coding gene Chr18:37098699-37191308 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024776
protein coding gene Chr18:38657747-38754420 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022215
protein coding gene Chr18:36037840-36127615 (-)
CAST/EiJ MGP_CASTEiJ_G0023575
protein coding gene Chr18:37055174-37149525 (-)
CBA/J MGP_CBAJ_G0024070
protein coding gene Chr18:39802133-39907320 (-)
DBA/2J MGP_DBA2J_G0024200
protein coding gene Chr18:35622004-35713252 (-)
FVB/NJ MGP_FVBNJ_G0024166
protein coding gene Chr18:35347939-35445908 (-)
LP/J MGP_LPJ_G0024284
protein coding gene Chr18:37382246-37475271 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024197
protein coding gene Chr18:41014599-41113337 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024825
protein coding gene Chr18:36908381-37001267 (-)
PWK/PhJ MGP_PWKPhJ_G0023319
protein coding gene Chr18:35858998-35951177 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023124
protein coding gene Chr18:37128161-37223416 (-)
WSB/EiJ MGP_WSBEiJ_G0023638
protein coding gene Chr18:36793399-36886864 (-)



Homology
more
  • Human Ortholog
    FGF1, fibroblast growth factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FGF1, fibroblast growth factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AFGF, ECGF, ECGFA, ECGFB, ECGF-beta, FGF-1, FGFA, FGF-alpha, GLIO703, HBGF1, HBGF-1
  • Links
    NCBI Gene ID: 2246
    neXtProt AC: NX_P05230
    UniProt: P05230

  • Chr Location
    5q31.3; chr5:142592178-142698070 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    11 phenotype references
Mice homozygous for a knock-out allele are viable, breed and develop normally, and exhibit normal brain structure and normal rates of wound healing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036585 Ensembl Gene Model | MGI Sequence Detail 90800 C57BL/6J ±  kb
transcript ENSMUST00000040647 Ensembl | MGI Sequence Detail 3981 Not Applicable  
polypeptide ENSMUSP00000045710 Ensembl | MGI Sequence Detail 155 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 76
    Genomic 12
    cDNA 51
    Primer pair 12
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-9760, MGD-MRK-9766, MGD-MRK-9773
References
more
  • Summaries
    All 177
    Developmental Gene Expression 69
    Gene Ontology 12
    Phenotypes 11
  • Earliest
    J:13138 Roberts E, A new mutation in the house mouse (Mus musculus). Science. 1931;74:569
  • Latest
    J:270543 Tanahashi H, et al., Deletion of Lrp4 increases the incidence of microphthalmia. Biochem Biophys Res Commun. 2018 Nov 30;506(3):478-484

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/01/2019
MGI 6.14
The Jackson Laboratory