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Fgf1
Gene Detail
Symbol

Name
ID
Fgf1
fibroblast growth factor 1
MGI:95515
Synonyms
Fgf-1, Fgfa, fibroblast growth factor 1 (acidic)
Feature Type
protein coding gene
Genetic Map
Chromosome 18
20.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr18:38838673-38929404 bp, - strand
From VEGA annotation of GRCm38

  90732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:625  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: FGF1
Protein SuperFamily: fibroblast growth factor
Gene Tree: Fgf1

Human
homologs
FGF1, fibroblast growth factor 1 (acidic)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2246
neXtProt AC: NX_P05230

Human Synonyms: AFGF, ECGF, ECGFA, ECGFB, ECGF-beta, FGF-1, FGFA, FGF-alpha, GLIO703, HBGF1, HBGF-1

Human Chr (Location): 5q31; chr5:142592178-142698070 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(58) : Gene trapped(54) Targeted(4)
 
Mice homozygous for a knock-out allele are viable, breed and develop normally, and exhibit normal brain structure and normal rates of wound healing.
 
Interactions
Fgf1 interacts with 339 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process angiogenesis, branch elongation involved in ureteric bud branching, ...
Component cytoplasm, cytosol, ...
Function fibroblast growth factor receptor binding, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (59 records)
Data Summary: Results (438)    Tissues (258)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 310
Northern blot 35
RT-PCR 93
cDNA source data(43)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase fgf1 ; ZFIN fgf1a    NEW 
Molecular
reagents
All nucleic(71) Genomic(12) cDNA(48) Primer pair(10) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000020317 (Evidence)
Ensembl Gene Model ENSMUSG00000036585 (Evidence)
Entrez Gene 14164 (Evidence)
UniGene 241282
DFCI TC1582787, TC1693688
DoTS DT.532392, DT.99788289, DT.99841324
NIA Mouse Gene Index U038363
Consensus CDS Project CCDS29204.1
International Mouse Phenotyping Consortium Status Fgf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020317 VEGA Gene Model | MGI Sequence Detail 90732 C57BL/6J ±  kb
transcript OTTMUST00000048206 VEGA | MGI Sequence Detail 3981 Not Applicable 
polypeptide OTTMUSP00000022029 VEGA | MGI Sequence Detail 155 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(22) UniProt(7)
Polymorphisms
RFLP(6) : SNPs within 2kb(928 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007479 fibroblast growth factor 1
References
(Earliest) J:13138 Roberts E, A new mutation in the house mouse (Mus musculus). Science. 1931;74:569
(Latest) J:216405 Oladipupo SS, et al., Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13379-84
All references(156)
Other
accession IDs
MGD-MRK-9760, MGD-MRK-9766, MGD-MRK-9773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory