Fes
Gene Detail

Symbol Name ID

Fes feline sarcoma oncogene MGI:95514

Synonyms

c-fes

Feature Type

protein coding gene

Genetic Map

Chromosome 7

45.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)

Sequence Map

Chr7:80377758-80387946 bp, - strand From NCBI annotation of GRCm38   10189 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37563  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, Fes/Fps type
Gene Tree: Fes

Human homologs

Human Homolog		FES, feline sarcoma oncogene
NCBI Gene ID		2242
neXtProt AC		NX_P07332
Human Synonyms		FPS
Human Chr (Location)		15q26.1; chr15:91427665-91439006 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygotes for a null allele show partial in utero lethality, runting, altered hematopoietic homeostasis and macrophage function, skin lesions and susceptibility to bacterial infection. Homozygotes for another null allele show enhanced LPS sensitivity, altered hematopoiesis and larger litter size.

 

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	peptidyl-tyrosine phosphorylation, phosphorylation, ...
Component	cell junction, cytoplasm, ...
Function	ATP binding, immunoglobulin receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (42)    Tissues (28)    Images (13)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	42

cDNA source data(44)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(56) Genomic(8) cDNA(45) Other(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000053158 (Evidence)
Entrez Gene	14159 (Evidence)
UniGene	48757
DFCI	TC1580561, TC1614218, TC1615323, TC1664281
DoTS	DT.101364044, DT.522466, DT.91339717, DT.99859879, DT.99859880, DT.99859884
NIA Mouse Gene Index	U028763
EC	2.7.10.2
Consensus CDS Project	CCDS39999.1
International Mouse Knockout Project Status	Fes

Sequences

Length	Strain/Species
genomic	14159	NCBI Gene Model | MGI Sequence Detail	10189	C57BL/6J
transcript	NM_010194	RefSeq | MGI Sequence Detail	2780	C57BL/6
polypeptide	P16879	UniProt | EBI | MGI Sequence Detail	822	Not Applicable

All sequences(36) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(7) : SNPs(167 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001060	Fps/Fes/Fer/CIP4 homology
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR000980	SH2 domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016250	Tyrosine-protein kinase, non-receptor Fes, subgroup
Protein Ontology	PR:000007463	tyrosine-protein kinase Fes/Fps

Graphical View of Protein Domain Structure

References

(Earliest) J:6419 Barbacid M, et al., Origin and functional properties of the major gene product of the Snyder-Theilen strain of feline sarcoma virus. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5158-62
(Latest) J:193475 Khajah M, et al., Fer Kinase Limits Neutrophil Chemotaxis toward End Target Chemoattractants. J Immunol. 2013 Mar 1;190(5):2208-16
All references(82)

Other accession IDs

MGD-MRK-9758, MGI:2142003, MGI:2142293