About   Help   FAQ
Fes
Gene Detail
Symbol

Name
ID
Fes
feline sarcoma oncogene
MGI:95514
Synonyms
c-fes
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr7:80377758-80387946 bp, - strand
From Ensembl annotation of GRCm38

  10189 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37563  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, Fes/Fps type
Gene Tree: Fes

Human
homologs
Human Homolog FES, FES proto-oncogene, tyrosine kinase
NCBI Gene ID 2242
neXtProt AC  NX_P07332
Human Synonyms  FPS
Human Chr (Location)  15q26.1; chr15:90884435-90895776 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show partial in utero lethality, runting, altered hematopoietic homeostasis and macrophage function, skin lesions and susceptibility to bacterial infection. Homozygotes for another null allele show enhanced LPS sensitivity, altered hematopoiesis and larger litter size.
 
Interactions
Fes interacts with 41 markers (Mir28b, Mir28c, Mir93, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process cell adhesion, cell differentiation, ...
Component cell junction, cytoplasm, ...
Function ATP binding, immunoglobulin receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (42)    Tissues (28)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
cDNA source data(44)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) Genomic(8) cDNA(45) Other(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000053158 (Evidence)
Entrez Gene14159 (Evidence)
UniGene48757
DFCITC1580561, TC1614218, TC1615323, TC1664281
DoTSDT.101364044, DT.522466, DT.91339717, DT.99859879, DT.99859880, DT.99859884
NIA Mouse Gene IndexU028763
EC2.7.10.2
Consensus CDS ProjectCCDS39999.1
International Mouse Knockout Project StatusFes
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053158 Ensembl Gene Model | MGI Sequence Detail 10189 C57BL/6J ±  kb
transcript ENSMUST00000080932 Ensembl | MGI Sequence Detail 2762 Not Applicable 
polypeptide ENSMUSP00000079733 Ensembl | MGI Sequence Detail 822 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(7) : SNPs within 2kb(197 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001060 FCH domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016250 Tyrosine-protein kinase, non-receptor Fes, subgroup
Protein Ontology PR:000007463 tyrosine-protein kinase Fes/Fps
References
(Earliest) J:6419 Barbacid M, et al., Origin and functional properties of the major gene product of the Snyder-Theilen strain of feline sarcoma virus. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5158-62
(Latest) J:194240 Zhang C, et al., Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5689-94
All references(87)
Other
accession IDs
MGD-MRK-9758, MGI:2142003, MGI:2142293

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory