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Fcer2a Gene Detail
Summary
  • Symbol
    Fcer2a
  • Name
    Fc receptor, IgE, low affinity II, alpha polypeptide
  • Synonyms
    CD23, Fce2, FC epsilon RII, low-affinity IgE receptor, Ly-42
  • Feature Type
    protein coding gene
  • IDs
    MGI:95497
    NCBI Gene: 14128
  • Gene Overview
    MyGene.info: FCER2
Location & Maps
more
  • Genetic Map
    Chromosome 8, 1.92 cM, cytoband A1
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    FCER2, Fc fragment of IgE receptor II
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FCER2, Fc fragment of IgE receptor II
    Orthology source: HomoloGene
  • Synonyms
    BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF
  • Links
    NCBI Gene ID: 2208
    neXtProt AC: NX_P06734

  • Chr Location
    19p13.3; chr19:7688757-7702310 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 6 alleles in 6 genetic backgrounds
    11 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Spontaneous
    1
  • Targeted
    4
  • Transgenic
    2
  • Incidental Mutations
Mice homozygous for mutations in this gene are essentially normal although IgE levels or IgE mediated responses may be abnormal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059173 VEGA Gene Model | MGI Sequence Detail 12439 C57BL/6J ±  kb
transcript OTTMUST00000145173 VEGA | MGI Sequence Detail 2242 Not Applicable  
polypeptide OTTMUSP00000075646 VEGA | MGI Sequence Detail 331 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    113 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 30
    Genomic 13
    cDNA 17

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11984, MGD-MRK-9727, MGD-MRK-9731
References
more
  • Summaries
    All 86
    Gene Ontology 10
    Phenotypes 33
  • Earliest
    J:9944 Holmes KL, et al., Murine hematopoietic cell surface antigen expression. Immunol Today. 1988 Nov;9(11):344-50
  • Latest
    J:224531 Wang TT, et al., Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy. Cell. 2015 Jul 2;162(1):160-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory