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Fcer2a
Gene Detail
Symbol

Name
ID
Fcer2a
Fc receptor, IgE, low affinity II, alpha polypeptide
MGI:95497
Synonyms
CD23, Fce2, FC epsilon RII, low-affinity IgE receptor, Ly-42
Feature Type
protein coding gene
Genetic Map
Chromosome 8
1.92 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr8:3681737-3694174 bp, - strand
From Ensembl annotation of GRCm38

  12438 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1517  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: FCER2
Protein SuperFamily: IgE receptor II
Gene Tree: Fcer2a

Human
homologs
FCER2, Fc fragment of IgE, low affinity II, receptor for (CD23)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2208
neXtProt AC: NX_P06734

Human Synonyms: BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF

Human Chr (Location): 19p13.3; chr19:7688757-7702310 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for mutations in this gene are essentially normal although IgE levels or IgE mediated responses may be abnormal.
 
Interactions
Fcer2a interacts with 135 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Expression
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(13) cDNA(17)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000005540 (Evidence)
Entrez Gene 14128 (Evidence)
UniGene 1233
DFCI TC1583158, TC1629609
DoTS DT.91385001, DT.94283500, DT.94283501, DT.97356933, DT.97408441, DT.97408442, DT.97408443
NIA Mouse Gene Index U029541
PDB 1HLJ
Consensus CDS Project CCDS22071.1
International Mouse Phenotyping Consortium Status Fcer2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005540 Ensembl Gene Model | MGI Sequence Detail 12438 C57BL/6J ±  kb
transcript ENSMUST00000005678 Ensembl | MGI Sequence Detail 2241 Not Applicable 
polypeptide ENSMUSP00000005678 Ensembl | MGI Sequence Detail 331 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(16) UniProt(3)
Polymorphisms
RFLP(3) : SNPs within 2kb(113 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000001880 low affinity immunoglobulin epsilon Fc receptor
References
(Earliest) J:9944 Holmes KL, et al., Murine hematopoietic cell surface antigen expression. Immunol Today. 1988 Nov;9(11):344-50
(Latest) J:198154 Lubben W, et al., IgE knock-in mice suggest a role for high levels of IgE in basophil-mediated active systemic anaphylaxis. Eur J Immunol. 2013 Apr;43(5):1231-42
All references(83)
Other
accession IDs
MGD-MRK-11984, MGD-MRK-9727, MGD-MRK-9731

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory