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Fcer2a
Gene Detail
Symbol

Name
ID
Fcer2a
Fc receptor, IgE, low affinity II, alpha polypeptide
MGI:95497
Synonyms
CD23, Fce2, FC epsilon RII, low-affinity IgE receptor, Ly-42
Feature Type
protein coding gene
Genetic Map
Chromosome 8
1.92 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr8:3681737-3694174 bp, - strand
From NCBI annotation of GRCm38

  12438 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1517  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: IgE receptor II
Gene Tree: Fcer2a

Human
homologs
Human Homolog FCER2, Fc fragment of IgE, low affinity II, receptor for (CD23)
NCBI Gene ID 2208
neXtProt AC  NX_P06734
Human Synonyms  BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF
Human Chr (Location)  19p13.3; chr19:7688757-7702146 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for mutations in this gene are essentially normal although IgE levels or IgE mediated responses may be abnormal.
 
Interactions
Fcer2a interacts with 135 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Expression
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(13) cDNA(17)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000005540 (Evidence)
Entrez Gene14128 (Evidence)
UniGene1233
DFCITC1583158, TC1629609
DoTSDT.91385001, DT.94283500, DT.94283501, DT.97356933, DT.97408441, DT.97408442, DT.97408443
NIA Mouse Gene IndexU029541
PDB1HLJ
Consensus CDS ProjectCCDS22071.1
International Mouse Knockout Project StatusFcer2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14128 NCBI Gene Model | MGI Sequence Detail 12438 C57BL/6J ±  kb
transcript NM_013517 RefSeq | MGI Sequence Detail 2241 C57BL/6 
polypeptide P20693 UniProt | EBI | MGI Sequence Detail 331 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(16) UniProt(5)
Polymorphisms
RFLP(3) : SNPs within 2kb(113 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000001880 low affinity immunoglobulin epsilon Fc receptor
Graphical View of Protein Domain Structure
References
(Earliest) J:9944 Holmes KL, et al., Murine hematopoietic cell surface antigen expression. Immunol Today. 1988 Nov;9(11):344-50
(Latest) J:198154 Lubben W, et al., IgE knock-in mice suggest a role for high levels of IgE in basophil-mediated active systemic anaphylaxis. Eur J Immunol. 2013 Apr;43(5):1231-42
All references(85)
Other
accession IDs
MGD-MRK-11984, MGD-MRK-9727, MGD-MRK-9731

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory