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Fcer2a Gene Detail
Summary
  • Symbol
    Fcer2a
  • Name
    Fc receptor, IgE, low affinity II, alpha polypeptide
  • Synonyms
    CD23, Fce2, FC epsilon RII, low-affinity IgE receptor, Ly-42
  • Feature Type
    protein coding gene
  • IDs
    MGI:95497
    NCBI Gene: 14128
Location & Maps
more
  • Sequence Map
    Chr8:3681737-3694174 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12438 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FCER2, Fc fragment of IgE receptor II
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FCER2, Fc fragment of IgE receptor II
    Orthology source: HomoloGene
  • Synonyms
    BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF
  • Links
    NCBI Gene ID: 2208
    neXtProt AC: NX_P06734

  • Chr Location
    19p13.3; chr19:7688757-7702310 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 6 alleles in 6 genetic backgrounds
    11 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Spontaneous
    1
  • Targeted
    4
  • Transgenic
    2
  • Incidental Mutations
Mice homozygous for mutations in this gene are essentially normal although IgE levels or IgE mediated responses may be abnormal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005540 Ensembl Gene Model | MGI Sequence Detail 12438 C57BL/6J ±  kb
transcript ENSMUST00000005678 Ensembl | MGI Sequence Detail 2241 Not Applicable  
polypeptide ENSMUSP00000005678 Ensembl | MGI Sequence Detail 331 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    113 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    Genomic 13
    cDNA 17

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11984, MGD-MRK-9727, MGD-MRK-9731
References
more
  • Summaries
    All 83
    Gene Ontology 10
    Phenotypes 32
  • Earliest
    J:9944 Holmes KL, et al., Murine hematopoietic cell surface antigen expression. Immunol Today. 1988 Nov;9(11):344-50
  • Latest
    J:224531 Wang TT, et al., Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy. Cell. 2015 Jul 2;162(1):160-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory