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Fcer2a Gene Detail
Summary
  • Symbol
    Fcer2a
  • Name
    Fc receptor, IgE, low affinity II, alpha polypeptide
  • Synonyms
    CD23, Fce2, FC epsilon RII, low-affinity IgE receptor, Ly-42
  • Feature Type
    protein coding gene
  • IDs
    MGI:95497
    NCBI Gene: 14128
  • Gene Overview
    MyGene.info: FCER2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:3681737-3694175 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 1.92 cM, cytoband A1
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95497
protein coding gene Chr8:3680144-3694175 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033316
protein coding gene Chr8:628707-644073 (-)
A/J MGP_AJ_G0033299
protein coding gene Chr8:598036-610605 (-)
AKR/J MGP_AKRJ_G0033230
protein coding gene Chr8:627990-640083 (-)
BALB/cJ MGP_BALBcJ_G0033299
protein coding gene Chr8:623815-636444 (-)
C3H/HeJ MGP_C3HHeJ_G0033013
protein coding gene Chr8:641279-655920 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033809
protein coding gene Chr8:674580-688632 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030782
protein coding gene Chr8:550557-563144 (-)
CAST/EiJ MGP_CASTEiJ_G0032336
protein coding gene Chr8:638869-651507 (-)
CBA/J MGP_CBAJ_G0032986
protein coding gene Chr8:689520-710797 (-)
DBA/2J MGP_DBA2J_G0033140
protein coding gene Chr8:568795-581393 (-)
FVB/NJ MGP_FVBNJ_G0033087
protein coding gene Chr8:617674-629369 (-)
LP/J MGP_LPJ_G0033232
protein coding gene Chr8:611626-623846 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033122
protein coding gene Chr8:667554-679579 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033827
protein coding gene Chr8:620859-634591 (-)
PWK/PhJ MGP_PWKPhJ_G0032046
protein coding gene Chr8:597628-610076 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031890
protein coding gene Chr8:610534-629429 (-)
WSB/EiJ MGP_WSBEiJ_G0032449
protein coding gene Chr8:617237-630814 (-)



Homology
more
  • Human Ortholog
    FCER2, Fc fragment of IgE receptor II
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FCER2, Fc fragment of IgE receptor II
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF
  • Links
    NCBI Gene ID: 2208
    neXtProt AC: NX_P06734
    UniProt: P06734

  • Chr Location
    19p13.2; chr19:7688757-7702755 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 6 alleles in 6 genetic backgrounds
    11 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for mutations in this gene are essentially normal although IgE levels or IgE mediated responses may be abnormal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005540 Ensembl Gene Model | MGI Sequence Detail 12439 C57BL/6J ±  kb
transcript ENSMUST00000005678 Ensembl | MGI Sequence Detail 2242 Not Applicable  
polypeptide ENSMUSP00000005678 Ensembl | MGI Sequence Detail 331 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 31
    Genomic 13
    cDNA 18

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11984, MGD-MRK-9727, MGD-MRK-9731
References
more
  • Summaries
    All 93
    Gene Ontology 10
    Phenotypes 33
  • Earliest
    J:9944 Holmes KL, et al., Murine hematopoietic cell surface antigen expression. Immunol Today. 1988 Nov;9(11):344-50
  • Latest
    J:236911 Garcia-Serna AM, et al., Dock10 regulates CD23 expression and sustains B-cell lymphopoiesis in secondary lymphoid tissue. Immunobiology. 2016 Dec;221(12):1343-1350

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory