Fcer1g
Gene Detail

Symbol Name ID

Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide MGI:95496

Synonyms

Fce1g, FcepsilonRI, FcR[g], FcRgamma, FcR-gamma, Ly-50

Feature Type

protein coding gene

Genetic Map

Chromosome 1

79.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr1:171229572-171234365 bp, - strand From VEGA annotation of GRCm38   4794 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3029  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: high affinity immunoglobulin epsilon receptor gamma-subunit
Gene Tree: Fcer1g

Human homologs

Human Homolog		FCER1G, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
NCBI Gene ID		2207
neXtProt AC		NX_P30273
Human Synonyms		FCRG
Human Chr (Location)		1q23; chr1:161185087-161189038 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygotes for targeted null mutations exhibit impairments in macrophage phagocytosis, NK cell-mediated antibody-coated cytotoxicity, mast cell degranulation, IgE-mediated systemic anaphylaxis, and neutrophil recruitment and migration.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (59 annotations)

Process	antigen processing and presentation of exogenous peptide antigen via MHC class I, antigen processing and presentation of exogenous peptide antigen via MHC class II, ...
Component	external side of plasma membrane, Fc-epsilon receptor I complex, ...
Function	IgE binding, IgE receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (38)    Tissues (24)    Images (11)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	38

cDNA source data(28)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(2) cDNA(30) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000021504 (Evidence)
Ensembl Gene Model	ENSMUSG00000058715 (Evidence)
Entrez Gene	14127 (Evidence)
UniGene	22673
DFCI	TC1580648, TC1587621
DoTS	DT.531420
NIA Mouse Gene Index	U161999
Consensus CDS Project	CCDS15483.1
International Mouse Knockout Project Status	Fcer1g

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021504	VEGA Gene Model | MGI Sequence Detail	4794	C57BL/6J
transcript	OTTMUST00000050975	VEGA | MGI Sequence Detail	674	Not Applicable
polypeptide	OTTMUSP00000023927	VEGA | MGI Sequence Detail	86	Not Applicable

All sequences(25) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003110	Phosphorylated immunoreceptor signaling ITAM
InterPro	IPR021663	T-cell surface glycoprotein CD3 zeta/eta subunit/High affinity IgE receptor gamma subunit
Protein Ontology	PR:000007432	high affinity immunoglobulin epsilon receptor subunit gamma

References

(Earliest) J:8413 Hibbs ML, et al., The murine Fc receptor for immunoglobulin: purification, partial amino acid sequence, and isolation of cDNA clones. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6980-4
(Latest) J:194334 Zietara N, et al., Immunoglobulins drive terminal maturation of splenic dendritic cells. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2282-7
All references(330)

Other accession IDs

MGD-MRK-11993, MGD-MRK-9726, MGD-MRK-9730, MGI:2138290