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Fcer1g Gene Detail
Summary
  • Symbol
    Fcer1g
  • Name
    Fc receptor, IgE, high affinity I, gamma polypeptide
  • Synonyms
    Fce1g, FcepsilonRI, FcR[g], FcRgamma, FcR-gamma, Ly-50
  • Feature Type
    protein coding gene
  • IDs
    MGI:95496
    NCBI Gene: 14127
  • Gene Overview
    MyGene.info: FCER1G
Location & Maps
more
  • Sequence Map
    Chr1:171229572-171234365 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4794 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.23 cM
  • Mapping Data
    16 experiments
Homology
more
  • Human Ortholog
    FCER1G, Fc fragment of IgE receptor Ig
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FCER1G, Fc fragment of IgE receptor Ig
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FCRG
  • Links
    NCBI Gene ID: 2207
    neXtProt AC: NX_P30273

  • Chr Location
    1q23.3; chr1:161215297-161219248 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 3 alleles in 7 genetic backgrounds
    52 phenotypes from multigenic genotypes
    341 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Fcer1g
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit impairments in macrophage phagocytosis, NK cell-mediated antibody-coated cytotoxicity, mast cell degranulation, IgE-mediated systemic anaphylaxis, and neutrophil recruitment and migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021504 VEGA Gene Model | MGI Sequence Detail 4794 C57BL/6J ±  kb
transcript OTTMUST00000127196 VEGA | MGI Sequence Detail 683 Not Applicable  
polypeptide OTTMUSP00000068685 VEGA | MGI Sequence Detail 92 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    97 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007432 high affinity immunoglobulin epsilon receptor subunit gamma
  • InterPro Domains
    IPR003110 Phosphorylated immunoreceptor signalling ITAM
    IPR021663 T-cell surface glycoprotein CD3 zeta subunit/High affinity IgE receptor gamma subunit
Molecular
Reagents
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  • All nucleic 33
    Genomic 2
    cDNA 30
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11993, MGD-MRK-9726, MGD-MRK-9730, MGI:2138290
References
more
  • Summaries
    All 395
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 25
    Phenotypes 341
  • Earliest
    J:8413 Hibbs ML, et al., The murine Fc receptor for immunoglobulin: purification, partial amino acid sequence, and isolation of cDNA clones. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6980-4
  • Latest
    J:232787 Morris ZS, et al., In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments. Cancer Res. 2016 Jul 1;76(13):3929-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory