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Ms4a2 Gene Detail
Summary
  • Symbol
    Ms4a2
  • Name
    membrane-spanning 4-domains, subfamily A, member 2
  • Synonyms
    Fce1b, Fcer1b, FcRB, Fcrbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:95495
    NCBI Gene: 14126
  • Member of
    Ms4ac cluster
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:11592887-11601083 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 8.46 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    140 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95495
 protein coding gene Chr19:11592881-11601154 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024879
 protein coding gene Chr19:9006215-9014390 (-)
A/J MGP_AJ_G0024853
 protein coding gene Chr19:8488732-8496882 (-)
AKR/J MGP_AKRJ_G0024828
 protein coding gene Chr19:8812365-8820534 (-)
BALB/cJ MGP_BALBcJ_G0024853
 protein coding gene Chr19:8493254-8501404 (-)
C3H/HeJ MGP_C3HHeJ_G0024619
 protein coding gene Chr19:8715041-8723233 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025301
 protein coding gene Chr19:9450654-9460102 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022725
 protein coding gene Chr19:8852114-8860195 (-)
CAST/EiJ MGP_CASTEiJ_G0024092
 protein coding gene Chr19:8303026-8311082 (-)
CBA/J MGP_CBAJ_G0024593
 protein coding gene Chr19:9507991-9516159 (-)
DBA/2J MGP_DBA2J_G0024720
 protein coding gene Chr19:8461381-8469542 (-)
FVB/NJ MGP_FVBNJ_G0024687
 protein coding gene Chr19:8495051-8503162 (-)
LP/J MGP_LPJ_G0024807
 protein coding gene Chr19:9005290-9013471 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024714
 protein coding gene Chr19:9405861-9413997 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025349
 protein coding gene Chr19:8799382-8807564 (-)
PWK/PhJ MGP_PWKPhJ_G0023836
 protein coding gene Chr19:7916720-7925202 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023642
 protein coding gene Chr19:7956282-7964350 (-)
WSB/EiJ MGP_WSBEiJ_G0024154
 protein coding gene Chr19:8649248-8657376 (-)



Homology
more
  • Human Ortholog
    MS4A2, membrane spanning 4-domains A2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MS4A2, membrane spanning 4-domains A2
  • Synonyms
    APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER
  • Links
    NCBI Gene ID: 2206
    neXtProt AC: NX_Q01362
    UniProt: Q01362

  • Chr Location
    11q12.1; chr11:60088259-60098467 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human MS4A2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased susceptibility to passive cutaneous anaphylaxis and abnormal mast cell physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    8
  • cDNA Data
    12
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024680 Ensembl Gene Model | MGI Sequence Detail 8197 C57BL/6J ±  kb
transcript ENSMUST00000164792 Ensembl | MGI Sequence Detail 1010 Not Applicable  
polypeptide ENSMUSP00000127373 Ensembl | MGI Sequence Detail 235 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9725, MGD-MRK-9729
References
more
  • Summaries
    All 51
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 16
  • Earliest
    J:39249 Kinet JP, et al., Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6483-7
  • Latest
    J:343485 Loste A, et al., Involvement of an IgE/Mast cell/B cell amplification loop in abdominal aortic aneurysm progression. PLoS One. 2023;18(12):e0295408
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory