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Ms4a2 Gene Detail
Summary
  • Symbol
    Ms4a2
  • Name
    membrane-spanning 4-domains, subfamily A, member 2
  • Synonyms
    Fce1b, Fcer1b, FcRB, Fcrbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:95495
    NCBI Gene: 14126
  • Member of
    Ms4ac cluster
  • Gene Overview
    MyGene.info: MS4A2
Location & Maps
more
  • Sequence Map
    Chr19:11615523-11623719 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8197 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 8.46 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    MS4A2, membrane spanning 4-domains A2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MS4A2, membrane spanning 4-domains A2
    Orthology source: HomoloGene
  • Synonyms
    APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1
  • Links
    NCBI Gene ID: 2206
    neXtProt AC: NX_Q01362

  • Chr Location
    11q12-q13; chr11:60088261-60098467 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MS4A2 associations

Human Disease Mouse Models
       IgE Responsiveness, Atopic; IGER   OMIM: 147050
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
Homozygous null mice display decreased susceptibility to passive cutaneous anaphylaxis and abnormal mast cell physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047239 VEGA Gene Model | MGI Sequence Detail 8197 C57BL/6J ±  kb
transcript OTTMUST00000122150 VEGA | MGI Sequence Detail 1010 Not Applicable  
polypeptide OTTMUSP00000067091 VEGA | MGI Sequence Detail 235 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    140 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000010656 high affinity immunoglobulin epsilon receptor subunit beta
  • InterPro Domains
    IPR007237 CD20-like family
    IPR030420 High affinity immunoglobulin epsilon receptor subunit beta
    IPR030417 Membrane-spanning 4-domains subfamily A
Molecular
Reagents
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  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-9725, MGD-MRK-9729
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:39249 Kinet JP, et al., Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6483-7
  • Latest
    J:217638 Dahdah A, et al., Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis. J Clin Invest. 2014 Oct;124(10):4577-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory