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Ms4a2
Gene Detail
 Symbol
Name
ID
Ms4a2
membrane-spanning 4-domains, subfamily A, member 2
MGI:95495
Synonyms Fce1b, Fcer1b, FcRB, Fcrbeta
Feature Type protein coding gene
Genetic Map
Chromosome 19
8.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr19:11617193-11623643 bp, - strand
From NCBI annotation of GRCm38

  6451 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:112  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Ms4a2

Human
homologs
Human Homolog MS4A2, membrane-spanning 4-domains, subfamily A, member 2
NCBI Gene ID 2206
neXtProt AC  NX_Q01362
Human Synonyms  APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1
Human Chr (Location)  11q12-q13; chr11:60088261-60098467 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MS4A2
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
 
Homozygous null mice display decreased susceptibility to passive cutaneous anaphylaxis and abnormal mast cell physiology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process activation of phospholipase C activity, cell surface receptor signaling pathway, ...
Component endosome, external side of plasma membrane, ...
Function IgE binding, IgE receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (2)   
Theiler Stages: 25, 28
Assay TypeResults
RT-PCR 24
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024680 (Evidence)
Entrez Gene14126 (Evidence)
UniGene329735
DFCITC1587952, TC1646564, TC1653411
DoTSDT.40156537, DT.101371269, DT.97370934
Consensus CDS ProjectCCDS29604.1
International Mouse Knockout Project StatusMs4a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14126 NCBI Gene Model | MGI Sequence Detail 6451 C57BL/6J ±  kb
transcript NM_013516 RefSeq | MGI Sequence Detail 2759 C57BL/6 
polypeptide P20490 UniProt | EBI | MGI Sequence Detail 235 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(14) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007237 CD20-like
Protein Ontology PR:000010656 high affinity immunoglobulin epsilon receptor subunit beta
Graphical View of Protein Domain Structure
References (Earliest) J:39249 Kinet JP, et al., Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6483-7
(Latest) J:184055 Nunomura S, et al., The FcRbeta- and gamma-ITAMs play crucial but distinct roles in the full activation of mast cells induced by IgEkappa and Protein L. J Immunol. 2012 Apr 15;188(8):4052-64
All references(43)
Other
accession IDs
MGD-MRK-9725, MGD-MRK-9729

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory