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Zfp521 Gene Detail
Summary
  • Symbol
    Zfp521
  • Name
    zinc finger protein 521
  • Synonyms
    B930086A16Rik, Evi3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95459
    NCBI Gene: 225207
  • Gene Overview
    MyGene.info: ZNF521
Location & Maps
more
  • Sequence Map
    Chr18:13687013-13972733 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      285721 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 7.68 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    ZNF521, zinc finger protein 521
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZNF521, zinc finger protein 521
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EHZF, Evi3
  • Links
    NCBI Gene ID: 25925
    neXtProt AC: NX_Q96K83

  • Chr Location
    18q11.2; chr18:25061924-25352250 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Zfp521 mouse models

Human Disease Mouse Models
       Schizophrenia; SCZD   OMIM: 181500 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 4 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    5 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal growth retardation, behavioral anomalies including hyperlocomotion, lower anxiety, higher impulsivity and impaired learning, abnormal formation of the neuronal cell layers of the dentate gyrus in the hippocampus, and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024420 Ensembl Gene Model | MGI Sequence Detail 285721 C57BL/6J ±  kb
transcript ENSMUST00000025288 Ensembl | MGI Sequence Detail 6152 Not Applicable  
polypeptide ENSMUSP00000025288 Ensembl | MGI Sequence Detail 1311 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1216 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000017953 zinc finger protein 521
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 76
    Genomic 2
    cDNA 73
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9672, MGI:2442279
References
more
  • Summaries
    All 52
    Developmental Gene Expression 15
    Diseases 1
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:20577 Davisson MT, et al., Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 18. Mamm Genome. 1993;4 Spec No:S253-60
  • Latest
    J:221586 Lou S, et al., Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors. J Neurosci. 2015 Apr 1;35(13):5317-29

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory