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Ets1
Gene Detail
 Symbol
Name
ID
Ets1
E26 avian leukemia oncogene 1, 5' domain
MGI:95455
Synonyms Ets-1, MGC:18571, p42Ets-1, p51Ets-1, Tpl1
Feature Type protein coding gene
Genetic Map
Chromosome 9
17.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
Chr9:32636221-32757820 bp, + strand
From VEGA annotation of GRCm38

  121600 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3837  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transforming factor C-ets
Gene Tree: Ets1

Human
homologs
Human Homolog ETS1, v-ets avian erythroblastosis virus E26 oncogene homolog 1
NCBI Gene ID 2113
neXtProt AC  NX_P14921
Human Synonyms  ETS-1, EWSR2, p54
Human Chr (Location)  11q23.3; chr11:128458761-128587558 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit reduced numbers of peripheral CD8+ T cells, impaired TCR-mediated activation of both CD4+ and CD8+ T cells, increased numbers of IgM-secreting plasma cells, and severely impaired NK cell development.
 
Interactions
Ets1 interacts with 400 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process cell differentiation, cell motility, ...
Component cytoplasm, intercellular bridge, ...
Function DNA binding, histone acetyltransferase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (304)    Tissues (258)    Images (41)
Theiler Stages: 2, 3, 4, 5, 16, 17, 18, 21, 22, 23, 25, 27, 28
Assay TypeResults
RNA in situ 293
RT-PCR 11
cDNA source data(125)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(143) Genomic(9) cDNA(128) Primer pair(4) Other(2)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000044662 (Evidence)
Ensembl Gene ModelENSMUSG00000032035 (Evidence)
Entrez Gene23871 (Evidence)
UniGene292415
DFCITC1579505, TC1593675, TC1636044, TC1650928, TC1709880, TC1719654
DoTSDT.101383676, DT.101735588, DT.102554682, DT.492124, DT.94178528, DT.97414895
NIA Mouse Gene IndexU010230
PDB1K7A, 1MDM, 2KMD, 1K78, 1K79, 1MD0, 1R36, 2JV3
Consensus CDS ProjectCCDS22954.1, CCDS40572.1
International Mouse Knockout Project StatusEts1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044662 VEGA Gene Model | MGI Sequence Detail 121600 C57BL/6J ±  kb
transcript OTTMUST00000117489 VEGA | MGI Sequence Detail 5080 Not Applicable 
polypeptide OTTMUSP00000065695 VEGA | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(6) UniProt(11)
Polymorphisms RFLP(8) : SNPs within 2kb(1218 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR003118 Pointed domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR016311 Transforming protein C-ets
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007221 protein C-ets-1
References (Earliest) J:8218 Watson DK, et al., Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans. Proc Natl Acad Sci U S A. 1986 Mar;83(6):1792-6
(Latest) J:201159 Zhou P, et al., Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15395-400
All references(158)
Other
accession IDs
MGD-MRK-15175, MGD-MRK-15200, MGD-MRK-9663, MGD-MRK-9665, MGI:2142990, MGI:2143054, MGI:98794

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory