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Ets1
Gene Detail
Symbol

Name
ID
Ets1
E26 avian leukemia oncogene 1, 5' domain
MGI:95455
Synonyms
Ets-1, MGC:18571, p42Ets-1, p51Ets-1, Tpl1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
17.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
Chr9:32636221-32757820 bp, + strand
From VEGA annotation of GRCm38

  121600 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3837  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ETS1
Protein SuperFamily: transforming factor C-ets
Gene Tree: Ets1

Human
homologs
ETS1, v-ets avian erythroblastosis virus E26 oncogene homolog 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2113
neXtProt AC: NX_P14921

Human Synonyms: c-ets-1, ETS-1, EWSR2, p54

Human Chr (Location): 11q23.3; chr11:128458761-128587584 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit reduced numbers of peripheral CD8+ T cells, impaired TCR-mediated activation of both CD4+ and CD8+ T cells, increased numbers of IgM-secreting plasma cells, and severely impaired NK cell development.
 
Interactions
Ets1 interacts with 400 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process cell differentiation, cell motility, ...
Component cytoplasm, intercellular bridge, ...
Function DNA binding, histone acetyltransferase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (304)    Tissues (258)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 293
RT-PCR 11
cDNA source data(125)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ets1 ; ZFIN ets1    NEW 
Molecular
reagents
All nucleic(143) Genomic(9) cDNA(128) Primer pair(4) Other(2)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000044662 (Evidence)
Ensembl Gene Model ENSMUSG00000032035 (Evidence)
Entrez Gene 23871 (Evidence)
UniGene 292415
DFCI TC1579505, TC1593675, TC1636044, TC1650928, TC1709880, TC1719654
DoTS DT.101383676, DT.101735588, DT.102554682, DT.492124, DT.94178528, DT.97414895
NIA Mouse Gene Index U010230
PDB 1K7A, 1MDM, 2KMD, 1K78, 1K79, 1MD0, 1R36, 2JV3
Consensus CDS Project CCDS22954.1, CCDS40572.1
International Mouse Phenotyping Consortium Status Ets1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044662 VEGA Gene Model | MGI Sequence Detail 121600 C57BL/6J ±  kb
transcript OTTMUST00000117489 VEGA | MGI Sequence Detail 5080 Not Applicable 
polypeptide OTTMUSP00000065695 VEGA | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(6) UniProt(11)
Polymorphisms
RFLP(8) : SNPs within 2kb(1218 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR003118 Pointed domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR016311 Transforming protein C-ets
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007221 protein C-ets-1
References
(Earliest) J:8218 Watson DK, et al., Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans. Proc Natl Acad Sci U S A. 1986 Mar;83(6):1792-6
(Latest) J:221094 Carracedo S, et al., Redundant role of protein kinase C delta and epsilon during mouse embryonic development. PLoS One. 2014;9(8):e103686
All references(157)
Other
accession IDs
MGD-MRK-15175, MGD-MRK-15200, MGD-MRK-9663, MGD-MRK-9665, MGI:2142990, MGI:2143054, MGI:98794

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory