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Ets1 Gene Detail
Summary
  • Symbol
    Ets1
  • Name
    E26 avian leukemia oncogene 1, 5' domain
  • Synonyms
    Ets-1, MGC:18571, p42Ets-1, p51Ets-1, Tpl1, vs
  • Feature Type
    protein coding gene
  • IDs
    MGI:95455
    NCBI Gene: 23871
  • Gene Overview
    MyGene.info: ETS1
Location & Maps
more
  • Sequence Map
    Chr9:32636221-32757820 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      121600 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ETS1, ETS proto-oncogene 1, transcription factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ETS1, ETS proto-oncogene 1, transcription factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    c-ets-1, ETS-1, EWSR2, p54
  • Links
    NCBI Gene ID: 2113
    neXtProt AC: NX_P14921

  • Chr Location
    11q23.3; chr11:128458761-128587584 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 6 alleles in 6 genetic backgrounds
    13 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    1
  • Spontaneous
    1
  • Targeted
    5
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit reduced numbers of peripheral CD8+ T cells, impaired TCR-mediated activation of both CD4+ and CD8+ T cells, increased numbers of IgM-secreting plasma cells, and severely impaired NK cell development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044662 VEGA Gene Model | MGI Sequence Detail 121600 C57BL/6J ±  kb
transcript OTTMUST00000117489 VEGA | MGI Sequence Detail 5080 Not Applicable  
polypeptide OTTMUSP00000065695 VEGA | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1210 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 143
    Genomic 9
    cDNA 128
    Primer pair 4
    Other 2

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-15175, MGD-MRK-15200, MGD-MRK-15415, MGD-MRK-9663, MGD-MRK-9665, MGI:2142990, MGI:2143054, MGI:98794, MGI:98939
References
more
  • Summaries
    All 162
    Developmental Gene Expression 30
    Gene Ontology 13
    Phenotypes 33
  • Earliest
    J:8218 Watson DK, et al., Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans. Proc Natl Acad Sci U S A. 1986 Mar;83(6):1792-6
  • Latest
    J:229761 Liu F, et al., TLR9-induced miR-155 and Ets-1 decrease expression of CD1d on B cells in SLE. Eur J Immunol. 2015 Jul;45(7):1934-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory