Erbb3
Gene Detail

Symbol Name ID

Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) MGI:95411

Synonyms

Erbb-3, Erbb3r, HER3

Feature Type

protein coding gene

Genetic Map

Chromosome 10

77.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr10:128567523-128589652 bp, - strand From VEGA annotation of GRCm38   22130 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20457  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: tyrosine-protein kinase, EGF receptor type
Gene Tree: Erbb3

Human homologs

Human Homolog		ERBB3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
NCBI Gene ID		2065
neXtProt AC		NX_P21860
Human Synonyms		c-erbB3, c-erbB-3, ErbB-3, erbB3-S, HER3, LCCS2, MDA-BF-1, p180-ErbB3, p45-sErbB3, p85-sErbB3
Human Chr (Location)		12q13; chr12:56473809-56497291 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ERBB3

Alleles and phenotypes

All alleles(28) : Targeted(12) Gene trapped(14) Chemically induced(2)
 

Homozygotes for targeted null mutations exhibit a lack of Schwann-cell precursors leading to loss of sensory and motor neurons, hypoplasia of the primary sympathetic ganglion chain, cardiac defects, impaired brain development, and embryonic lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (46 annotations)

Process	cranial nerve development, endocardial cushion development, ...
Component	apical plasma membrane, basolateral plasma membrane, ...
Function	ATP binding, growth factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (70 records)
Data Summary: Results (515)    Tissues (179)    Images (93)
Theiler Stages: 1, 2, 3, 4, 5, 14, 16, 17, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	21
RNA in situ	385
Western blot	10
RT-PCR	99

cDNA source data(109)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(117) Genomic(3) cDNA(111) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000029881 (Evidence)
Ensembl Gene Model	ENSMUSG00000018166 (Evidence)
Entrez Gene	13867 (Evidence)
UniGene	373043
DFCI	TC1581078, TC1597262
DoTS	DT.492347
NIA Mouse Gene Index	U032365, U206583
EC	2.7.10.1
Consensus CDS Project	CCDS24283.1
International Mouse Knockout Project Status	Erbb3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029881	VEGA Gene Model | MGI Sequence Detail	22130	C57BL/6J
transcript	OTTMUST00000074150	VEGA | MGI Sequence Detail	6016	Not Applicable
polypeptide	OTTMUSP00000038495	VEGA | MGI Sequence Detail	1339	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(55 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000494	EGF receptor, L domain
InterPro	IPR006211	Furin-like cysteine-rich domain
InterPro	IPR006212	Furin-like repeat
InterPro	IPR009030	Growth factor, receptor
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor
Protein Ontology	PR:000007159	receptor tyrosine-protein kinase erbB-3

References

(Earliest) J:18117 Kraus MH, et al., Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9193-7
(Latest) J:194074 Ahn Y, et al., Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93
All references(152)

Other accession IDs

MGD-MRK-9572, MGD-MRK-9574, MGI:1098642, MGI:2143908