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Erbb3 Gene Detail
Summary
  • Symbol
    Erbb3
  • Name
    erb-b2 receptor tyrosine kinase 3
  • Synonyms
    Erbb-3, Erbb3r, HER3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95411
    NCBI Gene: 13867
  • Gene Overview
    MyGene.info: ERBB3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128569368-128589501 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 77.10 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    216 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95411
protein coding gene Chr10:128567523-128589652 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017873
protein coding gene Chr10:132321070-132343192 (-)
A/J MGP_AJ_G0017848
protein coding gene Chr10:127007848-127029986 (-)
AKR/J MGP_AKRJ_G0017811
protein coding gene Chr10:130725171-130747481 (-)
BALB/cJ MGP_BALBcJ_G0017812
protein coding gene Chr10:127381670-127403748 (-)
C3H/HeJ MGP_C3HHeJ_G0017635
protein coding gene Chr10:130887568-130909661 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018267
protein coding gene Chr10:136800462-136823573 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015945
protein coding gene Chr10:120928075-120949982 (-)
CAST/EiJ MGP_CASTEiJ_G0017196
protein coding gene Chr10:131604636-131629520 (-)
CBA/J MGP_CBAJ_G0017605
protein coding gene Chr10:142362821-142387096 (-)
DBA/2J MGP_DBA2J_G0017711
protein coding gene Chr10:126065189-126087509 (-)
FVB/NJ MGP_FVBNJ_G0017706
protein coding gene Chr10:124988112-125011449 (-)
LP/J MGP_LPJ_G0017785
protein coding gene Chr10:132907979-132931362 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017734
protein coding gene Chr10:144946180-144970863 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018307
protein coding gene Chr10:130827711-130850955 (-)
PWK/PhJ MGP_PWKPhJ_G0016981
protein coding gene Chr10:126326880-126350058 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016770
protein coding gene Chr10:129940361-129962964 (-)
WSB/EiJ MGP_WSBEiJ_G0017255
protein coding gene Chr10:131044608-131067194 (-)



Homology
more
  • Human Ortholog
    ERBB3, erb-b2 receptor tyrosine kinase 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ERBB3, erb-b2 receptor tyrosine kinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    c-erbB3, c-erbB-3, ErbB-3, erbB3-S, FERLK, HER3, LCCS2, MDA-BF-1, p180-ErbB3, p45-sErbB3, p85-sErbB3
  • Links
    NCBI Gene ID: 2065
    neXtProt AC: NX_P21860
    UniProt: P21860

  • Chr Location
    12q13.2; chr12:56080025-56103507 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ERBB3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    85 phenotypes from 10 alleles in 13 genetic backgrounds
    18 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit a lack of Schwann-cell precursors leading to loss of sensory and motor neurons, hypoplasia of the primary sympathetic ganglion chain, cardiac defects, impaired brain development, and embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13867 NCBI Gene Model | MGI Sequence Detail 20134 C57BL/6J ±  kb
    transcript NM_010153 RefSeq | MGI Sequence Detail 5999 Not Specified  
    polypeptide Q61526 UniProt | EBI | MGI Sequence Detail 1339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 122
      Genomic 4
      cDNA 113
      Primer pair 4
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9572, MGD-MRK-9574, MGI:1098642, MGI:2143908
    References
    more
    • Summaries
      All 199
      Developmental Gene Expression 95
      Gene Ontology 15
      Phenotypes 43
    • Earliest
      J:18117 Kraus MH, et al., Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9193-7
    • Latest
      J:273093 Katsel P, et al., Overexpression of Truncated Human DISC1 Induces Appearance of Hindbrain Oligodendroglia in the Forebrain During Development. Schizophr Bull. 2018 Apr 6;44(3):515-524

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    07/16/2019
    MGI 6.14
    The Jackson Laboratory