About   Help   FAQ
Gene Detail
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Synonyms Erbb-3, Erbb3r, HER3
Feature Type protein coding gene
Genetic Map
Chromosome 10
77.10 cM
Detailed Genetic Map ± 1 cM

Mapping data(8)
Sequence Map
Chr10:128567523-128589652 bp, - strand
From VEGA annotation of GRCm38

  22130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:20457  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: tyrosine-protein kinase, EGF receptor type
Gene Tree: Erbb3

Human Homolog ERBB3, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
NCBI Gene ID 2065
neXtProt AC  NX_P21860
Human Synonyms  c-erbB3, c-erbB-3, ErbB-3, erbB3-S, HER3, LCCS2, MDA-BF-1, p180-ErbB3, p45-sErbB3, p85-sErbB3
Human Chr (Location)  12q13; chr12:56080025-56103507 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ERBB3
alleles, and
All mutations/alleles(27) : Chemically induced (ENU)(2) Gene trapped(13) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for targeted null mutations exhibit a lack of Schwann-cell precursors leading to loss of sensory and motor neurons, hypoplasia of the primary sympathetic ganglion chain, cardiac defects, impaired brain development, and embryonic lethality.
Erbb3 interacts with 250 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
All GO classifications: (49 annotations)
Process cranial nerve development, endocardial cushion development, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function ATP binding, growth factor binding, ...
External Resources: FuncBase
Literature Summary: (73 records)
Data Summary: Results (525)    Tissues (185)    Images (102)
Theiler Stages: 1, 2, 3, 4, 5, 14, 15, 16, 17, 19, 20, 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 26
RNA in situ 389
Western blot 10
RT-PCR 100
cDNA source data(110)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(119) Genomic(3) cDNA(112) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000029881 (Evidence)
Ensembl Gene ModelENSMUSG00000018166 (Evidence)
Entrez Gene13867 (Evidence)
DFCITC1581078, TC1597262
NIA Mouse Gene IndexU032365, U206583
Consensus CDS ProjectCCDS24283.1
International Mouse Knockout Project StatusErbb3
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029881 VEGA Gene Model | MGI Sequence Detail 22130 C57BL/6J ±  kb
transcript OTTMUST00000074150 VEGA | MGI Sequence Detail 6016 Not Applicable 
polypeptide OTTMUSP00000038495 VEGA | MGI Sequence Detail 1339 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(239 from dbSNP Build 137)
InterPro IPR000494 EGF receptor, L domain
InterPro IPR006211 Furin-like cysteine-rich domain
InterPro IPR006212 Furin-like repeat
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
Protein Ontology PR:000007159 receptor tyrosine-protein kinase erbB-3
References (Earliest) J:18117 Kraus MH, et al., Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9193-7
(Latest) J:203534 Kwon HS, et al., Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling. J Biol Chem. 2013 Sep 13;288(37):26357-71
All references(158)
accession IDs
MGD-MRK-9572, MGD-MRK-9574, MGI:1098642, MGI:2143908

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.19
The Jackson Laboratory