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Erbb3 Gene Detail
Summary
  • Symbol
    Erbb3
  • Name
    erb-b2 receptor tyrosine kinase 3
  • Synonyms
    Erbb-3, Erbb3r, HER3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95411
    NCBI Gene: 13867
  • Gene Overview
    MyGene.info: ERBB3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:128567523-128589652 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22130 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 77.10 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    ERBB3, erb-b2 receptor tyrosine kinase 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ERBB3, erb-b2 receptor tyrosine kinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    c-erbB3, c-erbB-3, ErbB-3, erbB3-S, HER3, LCCS2, MDA-BF-1, p180-ErbB3, p45-sErbB3, p85-sErbB3
  • Links
    NCBI Gene ID: 2065
    neXtProt AC: NX_P21860
    UniProt: P21860

  • Chr Location
    12q13.2; chr12:56080025-56103507 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ERBB3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    85 phenotypes from 10 alleles in 13 genetic backgrounds
    18 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit a lack of Schwann-cell precursors leading to loss of sensory and motor neurons, hypoplasia of the primary sympathetic ganglion chain, cardiac defects, impaired brain development, and embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000029881 VEGA Gene Model | MGI Sequence Detail 22130 C57BL/6J ±  kb
    transcript OTTMUST00000074150 VEGA | MGI Sequence Detail 6016 Not Applicable  
    polypeptide OTTMUSP00000038495 VEGA | MGI Sequence Detail 1339 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      239 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 122
      Genomic 4
      cDNA 113
      Primer pair 4
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
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    MGD-MRK-9572, MGD-MRK-9574, MGI:1098642, MGI:2143908
    References
    more
    • Summaries
      All 195
      Developmental Gene Expression 92
      Gene Ontology 15
      Phenotypes 40
    • Earliest
      J:18117 Kraus MH, et al., Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9193-7
    • Latest
      J:265181 Kim BJ, et al., RERE deficiency leads to decreased expression of GATA4 and the development of ventricular septal defects. Dis Model Mech. 2018 Aug 28;11(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory