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Erbb3 Gene Detail
Summary
  • Symbol
    Erbb3
  • Name
    erb-b2 receptor tyrosine kinase 3
  • Synonyms
    Erbb-3, Erbb3r, HER3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95411
    NCBI Gene: 13867
  • Gene Overview
    MyGene.info: ERBB3
Location & Maps
more
  • Sequence Map
    Chr10:128567523-128589652 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22130 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ERBB3, erb-b2 receptor tyrosine kinase 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ERBB3, erb-b2 receptor tyrosine kinase 3
    Orthology source: HomoloGene
  • Synonyms
    c-erbB3, c-erbB-3, ErbB-3, erbB3-S, HER3, LCCS2, MDA-BF-1, p180-ErbB3, p45-sErbB3, p85-sErbB3
  • Links
    NCBI Gene ID: 2065
    neXtProt AC: NX_P21860

  • Chr Location
    12q13; chr12:56080025-56103507 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ERBB3 associations

Human Disease Mouse Models
       Lethal Congenital Contracture Syndrome 2; LCCS2   OMIM: 607598
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    85 phenotypes from 10 alleles in 13 genetic backgrounds
    18 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Chemically induced (ENU)
    2
  • Gene trapped
    13
  • Targeted
    12
  • Transgenic
    1
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit a lack of Schwann-cell precursors leading to loss of sensory and motor neurons, hypoplasia of the primary sympathetic ganglion chain, cardiac defects, impaired brain development, and embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029881 VEGA Gene Model | MGI Sequence Detail 22130 C57BL/6J ±  kb
transcript OTTMUST00000074150 VEGA | MGI Sequence Detail 6016 Not Applicable  
polypeptide OTTMUSP00000038495 VEGA | MGI Sequence Detail 1339 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    239 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007159 receptor tyrosine-protein kinase erbB-3
  • EC
  • InterPro Domains
    IPR006211 Furin-like cysteine-rich domain
    IPR006212 Furin-like repeat
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR032778 Growth factor receptor domain 4
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR000494 Receptor L-domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
Molecular
Reagents
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  • All nucleic 119
    Genomic 3
    cDNA 112
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-9572, MGD-MRK-9574, MGI:1098642, MGI:2143908
References
more
  • Summaries
    All 167
    Developmental Gene Expression 81
    Gene Ontology 15
    Phenotypes 35
  • Earliest
    J:18117 Kraus MH, et al., Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9193-7
  • Latest
    J:222550 Zhu Y, et al., Chemokine Signaling Controls Integrity of Radial Glial Scaffold in Developing Spinal Cord and Consequential Proper Position of Boundary Cap Cells. J Neurosci. 2015 Jun 17;35(24):9211-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory