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Emx1 Gene Detail
Summary
  • Symbol
    Emx1
  • Name
    empty spiracles homeobox 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95387
    NCBI Gene: 13796
  • Gene Overview
    MyGene.info: EMX1
Location & Maps
more
  • Sequence Map
    Chr6:85187438-85204462 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17025 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.21 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    EMX1, empty spiracles homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EMX1, empty spiracles homeobox 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2016
    neXtProt AC: NX_Q04741

  • Chr Location
    2p13.2; chr2:72911148-72934891 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55799
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EMX1
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 6 alleles in 4 genetic backgrounds
    212 phenotypes from multigenic genotypes
    308 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Spontaneous
    1
  • Targeted
    12
  • Genomic Mutations
    1 involving Emx1
  • Incidental Mutations
Mice with this mutation are viable and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037267 VEGA Gene Model | MGI Sequence Detail 17025 C57BL/6J ±  kb
transcript OTTMUST00000096120 VEGA | MGI Sequence Detail 1561 Not Applicable  
polypeptide OTTMUSP00000053665 VEGA | MGI Sequence Detail 257 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    52 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    Genomic 1
    cDNA 17
    Primer pair 4
    Other 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9495
References
more
  • Summaries
    All 408
    Developmental Gene Expression 87
    Diseases 3
    Gene Ontology 12
    Phenotypes 308
  • Earliest
    J:1461 Simeone A, et al., Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J. 1992 Jul;11(7):2541-50
  • Latest
    J:236327 Zhu H, et al., Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice. Genesis. 2016 Aug;54(8):439-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory