Emx1
Gene Detail

Symbol Name ID

Emx1 empty spiracles homeobox 1 MGI:95387

Feature Type

protein coding gene

Genetic Map

Chromosome 6

37.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:85187438-85204462 bp, + strand From VEGA annotation of GRCm38   17025 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55799  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Emx1

Human homologs

Human Homolog		EMX1, empty spiracles homeobox 1
NCBI Gene ID		2016
neXtProt AC		NX_Q04741
Human Chr (Location)		2p13.2; chr2:73144604-73162020 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(10)
 

Mice with this mutation are viable and fertile.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	brain development, cerebral cortex development, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (77 records)
Data Summary: Results (168)    Tissues (77)    Images (48)
Theiler Stages: 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	143
In situ reporter (knock in)	11
Northern blot	2
RT-PCR	9

cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(16) Primer pair(4) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037267 (Evidence)
Ensembl Gene Model	ENSMUSG00000033726 (Evidence)
Entrez Gene	13796 (Evidence)
UniGene	391473
DFCI	TC1588999
DoTS	DT.101264688, DT.110501286
NIA Mouse Gene Index	U007099
Consensus CDS Project	CCDS20290.1
International Mouse Knockout Project Status	Emx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037267	VEGA Gene Model | MGI Sequence Detail	17025	C57BL/6J
transcript	OTTMUST00000096120	VEGA | MGI Sequence Detail	1561	Not Applicable
polypeptide	OTTMUSP00000053665	VEGA | MGI Sequence Detail	257	Not Applicable

All sequences(27) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(39 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000007068	homeobox protein EMX1

References

(Earliest) J:1461 Simeone A, et al., Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J. 1992 Jul;11(7):2541-50
(Latest) J:194480 Ma S, et al., Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling. PLoS Biol. 2013 Jan;11(1):e1001469
All references(267)

Other accession IDs

MGD-MRK-9495