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Emx1
Gene Detail
Symbol

Name
ID
Emx1
empty spiracles homeobox 1
MGI:95387
Feature Type
protein coding gene
Genetic Map
Chromosome 6
37.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:85187438-85204462 bp, + strand
From VEGA annotation of GRCm38

  17025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55799  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EMX1
Gene Tree: Emx1

Human
homologs
EMX1, empty spiracles homeobox 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2016
neXtProt AC: NX_Q04741

Human Chr (Location): 2p13.2; chr2:72911148-72934891 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Spontaneous(1) Targeted(11)
Genomic Mutations involving Emx1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice with this mutation are viable and fertile.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Emx1 interacts with 50 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process brain development, brain morphogenesis, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (83 records)
Data Summary: Results (178)    Tissues (86)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 144
In situ reporter (knock in) 11
Northern blot 2
RT-PCR 9
cDNA source data(14)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase emx1, emx1.2 ; ZFIN emx1    NEW 
Molecular
reagents
All nucleic(22) cDNA(16) Primer pair(4) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037267 (Evidence)
Ensembl Gene Model ENSMUSG00000033726 (Evidence)
Entrez Gene 13796 (Evidence)
UniGene 391473
DFCI TC1588999
DoTS DT.101264688, DT.110501286
NIA Mouse Gene Index U007099
Consensus CDS Project CCDS20290.1
International Mouse Phenotyping Consortium Status Emx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037267 VEGA Gene Model | MGI Sequence Detail 17025 C57BL/6J ±  kb
transcript OTTMUST00000096120 VEGA | MGI Sequence Detail 1561 Not Applicable 
polypeptide OTTMUSP00000053665 VEGA | MGI Sequence Detail 257 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)    SNPs within 2kb including multiple locations(54)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeobox domain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000007068 homeobox protein EMX1
References
(Earliest) J:1461 Simeone A, et al., Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J. 1992 Jul;11(7):2541-50
(Latest) J:223290 Gil-Sanz C, et al., Lineage Tracing Using Cux2-Cre and Cux2-CreERT2 Mice. Neuron. 2015 May 20;86(4):1091-9
All references(350)
Other
accession IDs
MGD-MRK-9495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory