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Emx1 Gene Detail
Summary
  • Symbol
    Emx1
  • Name
    empty spiracles homeobox 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95387
    NCBI Gene: 13796
  • Gene Overview
    MyGene.info: EMX1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:85187931-85204463 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95387
protein coding gene Chr6:85187438-85204463 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030949
protein coding gene Chr6:86328414-86345255 (+)
A/J MGP_AJ_G0030918
protein coding gene Chr6:83041384-83062936 (+)
AKR/J MGP_AKRJ_G0030846
protein coding gene Chr6:85449908-85466899 (+)
BALB/cJ MGP_BALBcJ_G0030928
protein coding gene Chr6:83038322-83055711 (+)
C3H/HeJ MGP_C3HHeJ_G0030782
protein coding gene Chr6:98969917-98991387 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031388
protein coding gene Chr6:88707966-88740360 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028573
protein coding gene Chr6:81327764-81344682 (+)
CAST/EiJ MGP_CASTEiJ_G0030037
protein coding gene Chr6:85467248-85490229 (+)
CBA/J MGP_CBAJ_G0030615
protein coding gene Chr6:92215142-92236673 (+)
DBA/2J MGP_DBA2J_G0030768
protein coding gene Chr6:82329310-82347442 (+)
FVB/NJ MGP_FVBNJ_G0030721
protein coding gene Chr6:81533524-81550878 (+)
LP/J MGP_LPJ_G0030847
protein coding gene Chr6:86327966-86345328 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030757
protein coding gene Chr6:96403919-96420874 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031412
protein coding gene Chr6:85257452-85275191 (+)
PWK/PhJ MGP_PWKPhJ_G0029752
protein coding gene Chr6:81264300-81281560 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029580
protein coding gene Chr6:84113405-84132380 (+)
WSB/EiJ MGP_WSBEiJ_G0030118
protein coding gene Chr6:85694471-85717857 (+)



Homology
more
  • Human Ortholog
    EMX1, empty spiracles homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EMX1, empty spiracles homeobox 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2016
    neXtProt AC: NX_Q04741
    UniProt: Q04741

  • Chr Location
    2p13.2; chr2:72911147-72936691 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55799
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EMX1
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    3 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 6 alleles in 4 genetic backgrounds
    241 phenotypes from multigenic genotypes
    1 images
    490 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice with this mutation are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13796 NCBI Gene Model | MGI Sequence Detail 16533 C57BL/6J ±  kb
    transcript NM_010131 RefSeq | MGI Sequence Detail 1188 C57BL/6  
    polypeptide Q04742 UniProt | EBI | MGI Sequence Detail 257 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 1
      cDNA 19
      Primer pair 4
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9495
    References
    more
    • Summaries
      All 604
      Developmental Gene Expression 99
      Diseases 7
      Gene Ontology 15
      Phenotypes 490
    • Earliest
      J:1461 Simeone A, et al., Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J. 1992 Jul;11(7):2541-50
    • Latest
      J:278483 Shi L, et al., Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion. Nat Commun. 2019 Jun 13;10(1):2588

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/10/2019
    MGI 6.14
    The Jackson Laboratory