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Egr2 Gene Detail
Summary
  • Symbol
    Egr2
  • Name
    early growth response 2
  • Synonyms
    Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25
  • Feature Type
    protein coding gene
  • IDs
    MGI:95296
    NCBI Gene: 13654
  • Gene Overview
    MyGene.info: EGR2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:67535475-67542188 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6714 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 34.96 cM, cytoband B5
  • Mapping Data
    16 experiments
Homology
more
  • Human Ortholog
    EGR2, early growth response 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EGR2, early growth response 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AT591, CMT1D, CMT4E, KROX20
  • Links
    NCBI Gene ID: 1959
    neXtProt AC: NX_P11161
    UniProt: P11161

  • Chr Location
    10q21.3; chr10:62811996-62819167 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20123
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EGR2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Egr2 mouse models; 3 with human EGR2 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    77 phenotypes from 7 alleles in 7 genetic backgrounds
    45 phenotypes from multigenic genotypes
    5 images
    110 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations exhibit absence of rhombomeres 3 and 5 of the hindbrain affecting axonal migration, disrupted myelination of Schwann cells, slow respiratory and jaw opening rhythms, skeletal abnormalities, and perinatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033571 VEGA Gene Model | MGI Sequence Detail 6714 C57BL/6J ±  kb
transcript OTTMUST00000084546 VEGA | MGI Sequence Detail 2965 Not Applicable  
polypeptide OTTMUSP00000045576 VEGA | MGI Sequence Detail 470 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    10 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 81
    Genomic 5
    cDNA 44
    Primer pair 6
    Other 26

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11620, MGD-MRK-15869, MGD-MRK-9325, MGD-MRK-9327
References
more
  • Summaries
    All 404
    Developmental Gene Expression 223
    Diseases 2
    Gene Ontology 19
    Phenotypes 110
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:247879 Singh R, et al., Egr2 and 3 Inhibit T-bet-Mediated IFN-gamma Production in T Cells. J Immunol. 2017 Jun 01;198(11):4394-4402

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory