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Egr2
Gene Detail
Symbol

Name
ID
Egr2
early growth response 2
MGI:95296
Synonyms
Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25
Feature Type
protein coding gene
Genetic Map
Chromosome 10
34.96 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr10:67535475-67542188 bp, + strand
From VEGA annotation of GRCm38

  6714 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20123  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EGR2
Gene Tree: Egr2

Human
homologs
EGR2, early growth response 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1959
neXtProt AC: NX_P11161

Human Synonyms: AT591, CMT1D, CMT4E, KROX20

Human Chr (Location): 10q21.1; chr10:62811996-62919895 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human EGR2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations exhibit absence of rhombomeres 3 and 5 of the hindbrain affecting axonal migration, disrupted myelination of Schwann cells, slow respiratory and jaw opening rhythms, skeletal abnormalities, and perinatal lethality.
 
Human Diseases Modeled in Mice Using Egr2 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(5)
Interactions
Egr2 interacts with 246 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process brain segmentation, cellular response to cAMP, ...
Component cytoplasm, nucleus
Function chromatin binding, coenzyme F420-0 gamma-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (208 records)
Data Summary: Results (468)    Tissues (111)    Images (214)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 48
RNA in situ 387
In situ reporter (knock in) 26
RT-PCR 7
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase egr2 ; ZFIN egr2a, egr2b    NEW 
Molecular
reagents
All nucleic(79) Genomic(5) cDNA(43) Primer pair(6) Other(25)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000033571 (Evidence)
Ensembl Gene Model ENSMUSG00000037868 (Evidence)
Entrez Gene 13654 (Evidence)
UniGene 290421
DFCI TC1578922, TC1612353
DoTS DT.97398731
NIA Mouse Gene Index U011618
EC 6.3.2.-
Consensus CDS Project CCDS35927.2
International Mouse Phenotyping Consortium Status Egr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033571 VEGA Gene Model | MGI Sequence Detail 6714 C57BL/6J ±  kb
transcript OTTMUST00000084546 VEGA | MGI Sequence Detail 2965 Not Applicable 
polypeptide OTTMUSP00000045576 VEGA | MGI Sequence Detail 470 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(20) UniProt(7)
Polymorphisms
PCR(1) : SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021849 Protein of unknown function DUF3446
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000003469 early growth response protein 2
References
(Earliest) J:9144 Chavrier P, et al., A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells. EMBO J. 1988 Jan;7(1):29-35
(Latest) J:222248 Fossat N, et al., Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo. Development. 2015 Jun 1;142(11):2069-79
All references(357)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11620, MGD-MRK-15869, MGD-MRK-9325, MGD-MRK-9327

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory