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Egr2 Gene Detail
Summary
  • Symbol
    Egr2
  • Name
    early growth response 2
  • Synonyms
    Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25
  • Feature Type
    protein coding gene
  • IDs
    MGI:95296
    NCBI Gene: 13654
  • Gene Overview
    MyGene.info: EGR2
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:67535475-67542188 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 34.96 cM, cytoband B5
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95296
protein coding gene Chr10:67534453-67547493 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017324
protein coding gene Chr10:67299227-67307280 (+)
A/J MGP_AJ_G0017301
protein coding gene Chr10:65058344-65065043 (+)
AKR/J MGP_AKRJ_G0017262
protein coding gene Chr10:66831089-66837802 (+)
BALB/cJ MGP_BALBcJ_G0017261
protein coding gene Chr10:65254179-65260892 (+)
C3H/HeJ MGP_C3HHeJ_G0017085
protein coding gene Chr10:66821981-66828694 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017719
protein coding gene Chr10:69737514-69745556 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015409
protein coding gene Chr10:61739859-61746568 (+)
CAST/EiJ MGP_CASTEiJ_G0016655
protein coding gene Chr10:66868632-66876798 (+)
CBA/J MGP_CBAJ_G0017057
protein coding gene Chr10:72393793-72403755 (+)
DBA/2J MGP_DBA2J_G0017162
protein coding gene Chr10:64428991-64435646 (+)
FVB/NJ MGP_FVBNJ_G0017155
protein coding gene Chr10:63598195-63605138 (+)
LP/J MGP_LPJ_G0017235
protein coding gene Chr10:67715160-67722611 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017183
protein coding gene Chr10:74621237-74627899 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017758
protein coding gene Chr10:66724057-66730765 (+)
PWK/PhJ MGP_PWKPhJ_G0016439
protein coding gene Chr10:64226650-64233650 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016221
protein coding gene Chr10:66088906-66096858 (+)
WSB/EiJ MGP_WSBEiJ_G0016719
protein coding gene Chr10:66647343-66654922 (+)



Homology
more
  • Human Ortholog
    EGR2, early growth response 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EGR2, early growth response 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AT591, CMT1D, CMT4E, KROX20
  • Links
    NCBI Gene ID: 1959
    neXtProt AC: NX_P11161
    UniProt: P11161

  • Chr Location
    10q21.3; chr10:62811996-62819167 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20123
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EGR2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Egr2 mouse models; 3 with human EGR2 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    77 phenotypes from 7 alleles in 7 genetic backgrounds
    45 phenotypes from multigenic genotypes
    5 images
    120 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations exhibit absence of rhombomeres 3 and 5 of the hindbrain affecting axonal migration, disrupted myelination of Schwann cells, slow respiratory and jaw opening rhythms, skeletal abnormalities, and perinatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037868 Ensembl Gene Model | MGI Sequence Detail 6714 C57BL/6J ±  kb
    transcript ENSMUST00000048289 Ensembl | MGI Sequence Detail 2965 Not Applicable  
    polypeptide ENSMUSP00000041053 Ensembl | MGI Sequence Detail 470 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 5
      cDNA 45
      Primer pair 6
      Other 28

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11620, MGD-MRK-15869, MGD-MRK-9325, MGD-MRK-9327
    References
    more
    • Summaries
      All 432
      Developmental Gene Expression 234
      Diseases 2
      Gene Ontology 22
      Phenotypes 120
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:266434 Hong SH, et al., Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10381-10386

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory