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Egr2 Gene Detail
Summary
  • Symbol
    Egr2
  • Name
    early growth response 2
  • Synonyms
    Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25
  • Feature Type
    protein coding gene
  • IDs
    MGI:95296
    NCBI Gene: 13654
  • Gene Overview
    MyGene.info: EGR2
Location & Maps
more
  • Sequence Map
    Chr10:67535475-67542188 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6714 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    EGR2, early growth response 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EGR2, early growth response 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AT591, CMT1D, CMT4E, KROX20
  • Links
    NCBI Gene ID: 1959
    neXtProt AC: NX_P11161

  • Chr Location
    10q21.1; chr10:62811996-62919895 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 20123
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: EGR2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Egr2 mouse models; 3 with human EGR2 associations

Human Disease Mouse Models
       Neuropathy, Congenital Hypomyelinating or Amyelinating, Autosomal Recessive; CHN   OMIM: 605253 View 2 models
       Charcot-Marie-Tooth Disease, Demyelinating, Type 1D; CMT1D   OMIM: 607678
Hypertrophic Neuropathy of Dejerine-Sottas   OMIM: 145900
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    77 phenotypes from 7 alleles in 7 genetic backgrounds
    43 phenotypes from multigenic genotypes
    5 images
    99 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    11
  • Genomic Mutations
    2 involving Egr2
  • Incidental Mutations
Homozygotes for targeted mutations exhibit absence of rhombomeres 3 and 5 of the hindbrain affecting axonal migration, disrupted myelination of Schwann cells, slow respiratory and jaw opening rhythms, skeletal abnormalities, and perinatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033571 VEGA Gene Model | MGI Sequence Detail 6714 C57BL/6J ±  kb
transcript OTTMUST00000084546 VEGA | MGI Sequence Detail 2965 Not Applicable  
polypeptide OTTMUSP00000045576 VEGA | MGI Sequence Detail 470 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    10 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 79
    Genomic 5
    cDNA 43
    Primer pair 6
    Other 25

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11620, MGD-MRK-15869, MGD-MRK-9325, MGD-MRK-9327
References
more
  • Summaries
    All 362
    Developmental Gene Expression 212
    Diseases 2
    Gene Ontology 20
    Phenotypes 99
  • Earliest
    J:9144 Chavrier P, et al., A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells. EMBO J. 1988 Jan;7(1):29-35
  • Latest
    J:227617 Garrett AM, et al., Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse. Front Mol Neurosci. 2016;9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory