Egr2
Gene Detail

Symbol Name ID

Egr2 early growth response 2 MGI:95296

Synonyms

Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25

Feature Type

protein coding gene

Genetic Map

Chromosome 10

34.96 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(16)

Sequence Map

Chr10:67535475-67542188 bp, + strand From VEGA annotation of GRCm38   6714 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20123  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Egr2

Human homologs

Human Homolog		EGR2, early growth response 2
NCBI Gene ID		1959
neXtProt AC		NX_P11161
Human Synonyms		AT591, CMT1D, CMT4E, KROX20
Human Chr (Location)		10q21.1; chr10:64571756-64578927 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human EGR2

Alleles and phenotypes

All alleles(10) : Targeted(10)
 

Homozygotes for targeted mutations exhibit absence of rhombomeres 3 and 5 of the hindbrain affecting axonal migration, disrupted myelination of Schwann cells, slow respiratory and jaw opening rhythms, skeletal abnormalities, and perinatal lethality.

 
Human Diseases Modeled Using Mouse Egr2 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	brain segmentation, cellular response to organic substance, ...
Component	cytoplasm, nucleus
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (195 records)
Data Summary: Results (448)    Tissues (109)    Images (188)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	46
RNA in situ	369
In situ reporter (knock in)	26
RT-PCR	7

cDNA source data(38)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(77) Genomic(5) cDNA(43) Primer pair(6) Other(23)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000033571 (Evidence)
Ensembl Gene Model	ENSMUSG00000037868 (Evidence)
Entrez Gene	13654 (Evidence)
UniGene	290421
DFCI	TC1578922, TC1612353
DoTS	DT.97398731
NIA Mouse Gene Index	U011618
EC	6.3.2.-
Consensus CDS Project	CCDS35927.2
International Mouse Knockout Project Status	Egr2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033571	VEGA Gene Model | MGI Sequence Detail	6714	C57BL/6J
transcript	OTTMUST00000084546	VEGA | MGI Sequence Detail	2965	Not Applicable
polypeptide	OTTMUSP00000045576	VEGA | MGI Sequence Detail	470	Not Applicable

All sequences(53) RefSeq(2) UniProt(7)

Polymorphisms

PCR(1) : SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR021849	Protein of unknown function DUF3446
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000003469	early growth response protein 2

References

(Earliest) J:9144 Chavrier P, et al., A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells. EMBO J. 1988 Jan;7(1):29-35
(Latest) J:195512 Wu Z, et al., Mast Cell Fc{varepsilon}RI-Induced Early Growth Response 2 Regulates CC Chemokine Ligand 1-Dependent CD4+ T Cell Migration. J Immunol. 2013 May 1;190(9):4500-7
All references(330)

Other accession IDs

MGD-MRK-11620, MGD-MRK-15869, MGD-MRK-9325, MGD-MRK-9327