Egr2 MGI Mouse Gene Detail - MGI:95296 - early growth response 2

Symbol

Egr2
Name

early growth response 2
Synonyms

Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25

Feature Type

protein coding gene
IDs

MGI:95296
NCBI Gene: 13654
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr10:67371305-67378018 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 34.96 cM, cytoband B5
Mapping Data

16 experiments

SNPs within 2kb

10 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95296	protein coding gene	Chr10:67370334-67383354 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017324	protein coding gene	Chr10:67299227-67307280 (+)
A/J	MGP_AJ_G0017301	protein coding gene	Chr10:65058344-65065043 (+)
AKR/J	MGP_AKRJ_G0017262	protein coding gene	Chr10:66831089-66837802 (+)
BALB/cJ	MGP_BALBcJ_G0017261	protein coding gene	Chr10:65254179-65260892 (+)
C3H/HeJ	MGP_C3HHeJ_G0017085	protein coding gene	Chr10:66821981-66828694 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017719	protein coding gene	Chr10:69737514-69745556 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015409	protein coding gene	Chr10:61739859-61746568 (+)
CAST/EiJ	MGP_CASTEiJ_G0016655	protein coding gene	Chr10:66868632-66876798 (+)
CBA/J	MGP_CBAJ_G0017057	protein coding gene	Chr10:72393793-72403755 (+)
DBA/2J	MGP_DBA2J_G0017162	protein coding gene	Chr10:64428991-64435646 (+)
FVB/NJ	MGP_FVBNJ_G0017155	protein coding gene	Chr10:63598195-63605138 (+)
LP/J	MGP_LPJ_G0017235	protein coding gene	Chr10:67715160-67722611 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017183	protein coding gene	Chr10:74621237-74627899 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017758	protein coding gene	Chr10:66724057-66730765 (+)
PWK/PhJ	MGP_PWKPhJ_G0016439	protein coding gene	Chr10:64226650-64233650 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016221	protein coding gene	Chr10:66088906-66096858 (+)
WSB/EiJ	MGP_WSBEiJ_G0016719	protein coding gene	Chr10:66647343-66654922 (+)

Human Ortholog

EGR2, early growth response 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EGR2, early growth response 2
Synonyms

AT591, CMT1D, CMT4E, KROX20
Links

HGNC:3239

NCBI Gene ID: 1959

neXtProt AC: NX_P11161

UniProt: P11161
Chr Location

10q21.3; chr10:62811996-62819167 (-) GRCh38

MGI Vertebrate Homology

Egr2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EGR2
Gene Tree

Egr2

Diseases

1 with Egr2 mouse models; 4 with human EGR2 associations

Human Disease

Mouse Models

Charcot-Marie-Tooth disease type 4E

IDs

View 2 models

Charcot-Marie-Tooth disease type 1D

IDs

Charcot-Marie-Tooth disease type 3

IDs

motor peripheral neuropathy

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

74 phenotypes from 6 alleles in 7 genetic backgrounds
51 phenotypes from multigenic genotypes
5 images
156 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

13
Genomic Mutations

2 involving Egr2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for targeted mutations exhibit absence of rhombomeres 3 and 5 of the hindbrain affecting axonal migration, disrupted myelination of Schwann cells, slow respiratory and jaw opening rhythms, skeletal abnormalities, and perinatal lethality.

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All GO Annotations

74
GO References

31

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1450
Tissues

136
cDNA Data

43
Literature Summary

259

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase egr2

ZFIN egr2a, egr2b

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All Sequences

65
RefSeq

14
UniProt

7
CCDS

CCDS35927.2, CCDS83706.1

Ensembl

ENSMUSG00000037868 (Evidence)
NCBI Gene

13654

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037868	Ensembl Gene Model \| MGI Sequence Detail	6714	C57BL/6J	± kb
transcript	ENSMUST00000048289	Ensembl \| MGI Sequence Detail	2965	Not Applicable
polypeptide	ENSMUSP00000041053	Ensembl \| MGI Sequence Detail	470	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000003469 early growth response protein 2

(term hierarchy)
EC

2.3.2.-
InterPro Domains

IPR021849 Early growth response, N-terminal

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 102

Genomic 5

cDNA 47

Primer pair 6

Other 44

Microarray probesets 5

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MGD-MRK-11620, MGD-MRK-15869, MGD-MRK-9325, MGD-MRK-9327

Summaries

All 500

Developmental Gene Expression 259

Diseases 2

Gene Ontology 31

Phenotypes 156
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345844 Guo Y, et al., Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32

TSS for Egr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93829	Chr10:67370342-67370355 (+)	-956 bp
Tssr93830	Chr10:67371295-67371322 (+)	4 bp
Tssr93831	Chr10:67371323-67371345 (+)	29 bp
Tssr93832	Chr10:67371493-67371503 (+)	193 bp
Tssr93833	Chr10:67373039-67373043 (+)	1,736 bp
Tssr93834	Chr10:67373691-67373707 (+)	2,394 bp
Tssr93835	Chr10:67373893-67373904 (+)	2,594 bp
Tssr93836	Chr10:67374016-67374025 (+)	2,716 bp
Tssr93837	Chr10:67374129-67374139 (+)	2,829 bp
Tssr93838	Chr10:67374293-67374329 (+)	3,006 bp
Tssr93839	Chr10:67374393-67374399 (+)	3,091 bp
Tssr93840	Chr10:67375080-67375093 (+)	3,782 bp
Tssr93841	Chr10:67375628-67375639 (+)	4,329 bp
Tssr93842	Chr10:67375683-67375708 (+)	4,391 bp
Tssr93843	Chr10:67375768-67375782 (+)	4,470 bp
Tssr93844	Chr10:67375804-67375831 (+)	4,513 bp
Tssr93845	Chr10:67375846-67375871 (+)	4,554 bp
Tssr93846	Chr10:67375877-67375919 (+)	4,593 bp
Tssr93847	Chr10:67376577-67376581 (+)	5,274 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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