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Egr2
Gene Detail
Symbol

Name
ID
Egr2
early growth response 2
MGI:95296
Synonyms
Egr-2, Krox20, Krox-20, NGF1-B, Zfp-25
Feature Type
protein coding gene
Genetic Map
Chromosome 10
34.96 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr10:67535475-67542188 bp, + strand
From VEGA annotation of GRCm38

  6714 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20123  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Egr2

Human
homologs
Human Homolog EGR2, early growth response 2
NCBI Gene ID 1959
neXtProt AC  NX_P11161
Human Synonyms  AT591, CMT1D, CMT4E, KROX20
Human Chr (Location)  10q21.1; chr10:62811996-62893517 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human EGR2
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations exhibit absence of rhombomeres 3 and 5 of the hindbrain affecting axonal migration, disrupted myelination of Schwann cells, slow respiratory and jaw opening rhythms, skeletal abnormalities, and perinatal lethality.
 
Human Diseases Modeled Using Mouse Egr2 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Egr2 interacts with 247 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process brain segmentation, cellular response to cAMP, ...
Component cytoplasm, nucleus
Function chromatin binding, coenzyme F420-0 gamma-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (205 records)
Data Summary: Results (468)    Tissues (111)    Images (200)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 48
RNA in situ 387
In situ reporter (knock in) 26
RT-PCR 7
cDNA source data(38)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(79) Genomic(5) cDNA(43) Primer pair(6) Other(25)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000033571 (Evidence)
Ensembl Gene ModelENSMUSG00000037868 (Evidence)
Entrez Gene13654 (Evidence)
UniGene290421
DFCITC1578922, TC1612353
DoTSDT.97398731
NIA Mouse Gene IndexU011618
EC6.3.2.-
Consensus CDS ProjectCCDS35927.2
International Mouse Knockout Project StatusEgr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033571 VEGA Gene Model | MGI Sequence Detail 6714 C57BL/6J ±  kb
transcript OTTMUST00000084546 VEGA | MGI Sequence Detail 2965 Not Applicable 
polypeptide OTTMUSP00000045576 VEGA | MGI Sequence Detail 470 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(16) UniProt(7)
Polymorphisms
PCR(1) : SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021849 Protein of unknown function DUF3446
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000003469 early growth response protein 2
References
(Earliest) J:9144 Chavrier P, et al., A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells. EMBO J. 1988 Jan;7(1):29-35
(Latest) J:209602 Li CL, et al., SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons. J Neurosci. 2014 Mar 12;34(11):4027-42
All references(353)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11620, MGD-MRK-15869, MGD-MRK-9325, MGD-MRK-9327

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory