Egr2^tm2Jmi
Targeted Allele Detail

Summary

• Symbol: Egr2^tm2Jmi
• Name: early growth response 2; targeted mutation 2, Jeffrey Milbrandt
• MGI ID: MGI:3836632
• Synonyms: Egr2^I26N
• Gene: Egr2 Location: Chr10:67371305-67378018 bp, + strand Genetic Position: Chr10, 34.96 cM, cytoband B5
• Alliance: Egr2^tm2Jmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145949
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: A point mutation was used to engineer the amino acid substitution of asparagine for isoleucine at position 268 (I268N). A floxed neo cassette was inserted into the intron upstream of the point mutation and was removed by germ line, cre mediated recombination. (J:145949)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egr2 Mutation: 31 strains or lines available

References

• Original: J:145949 Baloh RH, et al., Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation. J Neurosci. 2009 Feb 25;29(8):2312-21
• All: 1 reference(s)