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Egr1
Gene Detail
Symbol

Name
ID
Egr1
early growth response 1
MGI:95295
Synonyms
A530045N19Rik, Egr-1, ETR103, Krox-1, Krox24, Krox-24, NGF1-A, NGFIA, NGFI-A, TIS8, Zenk, Zfp-6, Zif268
Feature Type
protein coding gene
Genetic Map
Chromosome 18
18.76 cM, cytoband C/D
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr18:34859823-34864984 bp, + strand
From VEGA annotation of GRCm38

  5162 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56394  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EGR1
Gene Tree: Egr1

Human
homologs
EGR1, early growth response 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1958
neXtProt AC: NX_P18146

Human Synonyms: AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225

Human Chr (Location): 5q31.1; chr5:138465492-138469315 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted mutations are small and infertile due to pituitary defects. Mutants exhibit reductions in somatotropes and growth hormone content, and a lack of luteinizing hormone-beta expression. Ovaries lack luteinizing hormone receptors. Memory defects are also seen.
 
Interactions
Egr1 interacts with 247 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process BMP signaling pathway, cellular response to cAMP, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (44 records)
Data Summary: Results (282)    Tissues (173)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 273
Northern blot 1
RT-PCR 8
cDNA source data(102)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA EGR1 ; Xenbase egr1 ; ZFIN egr1    NEW 
Molecular
reagents
All nucleic(117) Genomic(9) cDNA(104) Primer pair(1) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021064 (Evidence)
Ensembl Gene Model ENSMUSG00000038418 (Evidence)
Entrez Gene 13653 (Evidence)
UniGene 181959
DFCI TC1575688, TC1595758
DoTS DT.102555491, DT.496919
NIA Mouse Gene Index U018551
PDB 1A1F, 1A1G, 1A1H, 1A1I, 1A1J, 1A1K, 1A1L, 1AAY, 1F2I, 1G2D, 1G2F, 1JK1, 1JK2, 1LLM, 1P47, 1ZAA
Consensus CDS Project CCDS29136.1
International Mouse Phenotyping Consortium Status Egr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021064 VEGA Gene Model | MGI Sequence Detail 5162 C57BL/6J ±  kb
transcript OTTMUST00000049827 VEGA | MGI Sequence Detail 4484 Not Applicable 
polypeptide OTTMUSP00000023149 VEGA | MGI Sequence Detail 533 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(6)
Polymorphisms
RFLP(4) : SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021839 Protein of unknown function DUF3432
InterPro IPR021849 Protein of unknown function DUF3446
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000006937 early growth response protein 1
References
(Earliest) J:27311 Sukhatme VP, et al., A novel early growth response gene rapidly induced by fibroblast, epithelial cell and lymphocyte mitogens. Oncogene Res. 1987 Sep-Oct;1(4):343-55
(Latest) J:220783 Scheicher R, et al., CDK6 as a key regulator of hematopoietic and leukemic stem cell activation. Blood. 2015 Jan 1;125(1):90-101
All references(244)
Other
accession IDs
MGD-MRK-11608, MGD-MRK-11621, MGD-MRK-15902, MGD-MRK-9324, MGD-MRK-9326, MGI:2444717

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory