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Egr1 Gene Detail
Summary
  • Symbol
    Egr1
  • Name
    early growth response 1
  • Synonyms
    A530045N19Rik, Egr-1, ETR103, Krox-1, Krox24, Krox-24, NGF1-A, NGFIA, NGFI-A, TIS8, Zenk, Zfp-6, Zif268
  • Feature Type
    protein coding gene
  • IDs
    MGI:95295
    NCBI Gene: 13653
  • Gene Overview
    MyGene.info: EGR1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:34861207-34864956 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 18.76 cM, cytoband C/D
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95295
protein coding gene Chr18:34859823-34864984 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024253
protein coding gene Chr18:33098769-33103919 (+)
A/J MGP_AJ_G0024219
protein coding gene Chr18:31977239-31982399 (+)
AKR/J MGP_AKRJ_G0024187
protein coding gene Chr18:32895526-32900685 (+)
BALB/cJ MGP_BALBcJ_G0024219
protein coding gene Chr18:32035327-32040658 (+)
C3H/HeJ MGP_C3HHeJ_G0023986
protein coding gene Chr18:32910060-32915931 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024661
protein coding gene Chr18:34367625-34372758 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022101
protein coding gene Chr18:32117402-32122582 (+)
CAST/EiJ MGP_CASTEiJ_G0023461
protein coding gene Chr18:32874941-32881343 (+)
CBA/J MGP_CBAJ_G0023954
protein coding gene Chr18:35306566-35315486 (+)
DBA/2J MGP_DBA2J_G0024086
protein coding gene Chr18:31631322-31636546 (+)
FVB/NJ MGP_FVBNJ_G0024053
protein coding gene Chr18:31317194-31322195 (+)
LP/J MGP_LPJ_G0024168
protein coding gene Chr18:33181274-33188471 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024081
protein coding gene Chr18:36561920-36567043 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024709
protein coding gene Chr18:32715266-32722645 (+)
PWK/PhJ MGP_PWKPhJ_G0023205
protein coding gene Chr18:31839238-31843194 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023013
protein coding gene Chr18:32998303-33004929 (+)
WSB/EiJ MGP_WSBEiJ_G0023524
protein coding gene Chr18:32646459-32652959 (+)



Homology
more
  • Human Ortholog
    EGR1, early growth response 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EGR1, early growth response 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225
  • Links
    NCBI Gene ID: 1958
    neXtProt AC: NX_P18146
    UniProt: P18146

  • Chr Location
    5q31.2; chr5:138465492-138469315 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56394
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EGR1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Egr1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    93 phenotypes from 5 alleles in 7 genetic backgrounds
    11 phenotypes from multigenic genotypes
    108 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations are small and infertile due to pituitary defects. Mutants exhibit reductions in somatotropes and growth hormone content, and a lack of luteinizing hormone-beta expression. Ovaries lack luteinizing hormone receptors. Memory defects are also seen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13653 NCBI Gene Model | MGI Sequence Detail 3750 C57BL/6J ±  kb
    transcript NM_007913 RefSeq | MGI Sequence Detail 3072 C57BL/6  
    polypeptide P08046 UniProt | EBI | MGI Sequence Detail 533 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 119
      Genomic 9
      cDNA 106
      Primer pair 1
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11608, MGD-MRK-11621, MGD-MRK-15902, MGD-MRK-9324, MGD-MRK-9326, MGI:2444717
    References
    more
    • Summaries
      All 317
      Developmental Gene Expression 57
      Diseases 1
      Gene Ontology 25
      Phenotypes 108
    • Earliest
      J:27311 Sukhatme VP, et al., A novel early growth response gene rapidly induced by fibroblast, epithelial cell and lymphocyte mitogens. Oncogene Res. 1987 Sep-Oct;1(4):343-55
    • Latest
      J:270443 Li Q, et al., Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing. Neuron. 2019 Jan 16;101(2):207-223.e10

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory