Egf
Gene Detail

Symbol Name ID

Egf epidermal growth factor MGI:95290

Feature Type

protein coding gene

Genetic Map

Chromosome 3

58.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(40)

Sequence Map

Chr3:129677575-129755322 bp, - strand From NCBI annotation of GRCm38   77748 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1483  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: pro-epidermal growth factor
Gene Tree: Egf

Human homologs

Human Homolog		EGF, epidermal growth factor
NCBI Gene ID		1950
neXtProt AC		NX_P01133
Human Synonyms		HOMG4, URG
Human Chr (Location)		4q25; chr4:110834040-110934118 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human EGF

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Null mutants have normal phenotype. Females triply null, for this locus and the amphiregulin and transforming growth factor alpha genes, are unable to nurse due to impaired mammary gland development and show mild integument and digestive system anomalies.

 

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	activation of MAPKK activity, angiogenesis, ...
Component	extracellular space, integral to membrane, ...
Function	calcium ion binding, epidermal growth factor receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (36 records)
Data Summary: Results (150)    Tissues (98)    Images (11)
Theiler Stages: 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	24
RT-PCR	121

cDNA source data(135)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(151) Genomic(3) cDNA(138) Primer pair(9) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000028017 (Evidence)
Entrez Gene	13645 (Evidence)
UniGene	252481
DFCI	TC1576243
DoTS	DT.530889, DT.91343632, DT.94338522, DT.94387049
NIA Mouse Gene Index	U024639
PDB	1A3P, 1EGF, 1EPG, 1EPH, 1EPI, 1EPJ, 3EGF, 1GK5
Consensus CDS Project	CCDS17833.1
International Mouse Knockout Project Status	Egf

Sequences

Length	Strain/Species
genomic	13645	NCBI Gene Model | MGI Sequence Detail	77748	C57BL/6J
transcript	NM_010113	RefSeq | MGI Sequence Detail	4757	Not Specified
polypeptide	P01132	UniProt | EBI | MGI Sequence Detail	1217	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(9) : SNPs(537 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR023413	Green fluorescent protein-like
InterPro	IPR000033	LDLR class B repeat
InterPro	IPR016317	Pro-epidermal growth factor
InterPro	IPR011042	Six-bladed beta-propeller, TolB-like
Protein Ontology	PR:000006928	pro-epidermal growth factor

Graphical View of Protein Domain Structure

References

(Earliest) J:70074 Nexo E, et al., Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development. Proc Natl Acad Sci U S A. 1980 May;77(5):2782-5
(Latest) J:189747 Lee J, et al., IL-6 amplifier, NF-kappaB-triggered positive feedback for IL-6 signaling, in grafts is involved in allogeneic rejection responses. J Immunol. 2012 Aug 15;189(4):1928-36
All references(202)

Other accession IDs

MGD-MRK-9315, MGI:2139798