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Egf
Gene Detail
Symbol

Name
ID
Egf
epidermal growth factor
MGI:95290
Feature Type
protein coding gene
Genetic Map
Chromosome 3
58.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(40)
Sequence Map
Chr3:129677575-129755322 bp, - strand
From Ensembl annotation of GRCm38

  77748 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1483  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EGF
Protein SuperFamily: pro-epidermal growth factor
Gene Tree: Egf

Human
homologs
EGF, epidermal growth factor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1950
neXtProt AC: NX_P01133

Human Synonyms: HOMG4, URG

Human Chr (Location): 4q25; chr4:109912883-110012962 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human EGF

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Null mutants have normal phenotype. Females triply null, for this locus and the amphiregulin and transforming growth factor alpha genes, are unable to nurse due to impaired mammary gland development and show mild integument and digestive system anomalies.
 
Interactions
Egf interacts with 102 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process activation of MAPKK activity, angiogenesis, ...
Component extracellular exosome, extracellular space, ...
Function calcium ion binding, epidermal growth factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (150)    Tissues (99)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 24
RT-PCR 121
cDNA source data(139)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA EGF ; Xenbase egf ; ZFIN egf    NEW 
Molecular
reagents
All nucleic(155) Genomic(3) cDNA(142) Primer pair(9) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000028017 (Evidence)
Entrez Gene 13645 (Evidence)
UniGene 252481
DFCI TC1576243
DoTS DT.530889, DT.91343632, DT.94338522, DT.94387049
NIA Mouse Gene Index U024639
PDB 1A3P, 1EGF, 1EPG, 1EPH, 1EPI, 1EPJ, 3EGF, 1GK5
Consensus CDS Project CCDS17833.1
International Mouse Phenotyping Consortium Status Egf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028017 Ensembl Gene Model | MGI Sequence Detail 77748 C57BL/6J ±  kb
transcript ENSMUST00000029653 Ensembl | MGI Sequence Detail 4757 Not Applicable 
polypeptide ENSMUSP00000029653 Ensembl | MGI Sequence Detail 1217 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(11) UniProt(3)
Polymorphisms
RFLP(9) : SNPs within 2kb(690 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR023413 Green fluorescent protein-like
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000033 LDLR class B repeat
InterPro IPR016317 Pro-epidermal growth factor
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000006928 pro-epidermal growth factor
References
(Earliest) J:70074 Nexo E, et al., Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development. Proc Natl Acad Sci U S A. 1980 May;77(5):2782-5
(Latest) J:221164 Di Giovanni V, et al., Fibroblast growth factor receptor-Frs2alpha signaling is critical for nephron progenitors. Dev Biol. 2015 Apr 1;400(1):82-93
All references(206)
Other
accession IDs
MGD-MRK-9315, MGI:2139798

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory