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Egf
Gene Detail
Symbol

Name
ID
Egf
epidermal growth factor
MGI:95290
Feature Type
protein coding gene
Genetic Map
Chromosome 3
58.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(40)
Sequence Map
Chr3:129677575-129755322 bp, - strand
From NCBI annotation of GRCm38

  77748 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1483  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: pro-epidermal growth factor
Gene Tree: Egf

Human
homologs
Human Homolog EGF, epidermal growth factor
NCBI Gene ID 1950
neXtProt AC  NX_P01133
Human Synonyms  HOMG4, URG
Human Chr (Location)  4q25; chr4:109912884-110012962 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human EGF
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Null mutants have normal phenotype. Females triply null, for this locus and the amphiregulin and transforming growth factor alpha genes, are unable to nurse due to impaired mammary gland development and show mild integument and digestive system anomalies.
 
Interactions
Egf interacts with 102 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process activation of MAPKK activity, angiogenesis, ...
Component extracellular space, extracellular vesicular exosome, ...
Function calcium ion binding, epidermal growth factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (150)    Tissues (99)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 24
RT-PCR 121
cDNA source data(139)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(155) Genomic(3) cDNA(142) Primer pair(9) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000028017 (Evidence)
Entrez Gene13645 (Evidence)
UniGene252481
DFCITC1576243
DoTSDT.530889, DT.91343632, DT.94338522, DT.94387049
NIA Mouse Gene IndexU024639
PDB1A3P, 1EGF, 1EPG, 1EPH, 1EPI, 1EPJ, 3EGF, 1GK5
Consensus CDS ProjectCCDS17833.1
International Mouse Knockout Project StatusEgf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13645 NCBI Gene Model | MGI Sequence Detail 77748 C57BL/6J ±  kb
transcript NM_010113 RefSeq | MGI Sequence Detail 4757 Not Specified 
polypeptide P01132 UniProt | EBI | MGI Sequence Detail 1217 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(9) UniProt(3)
Polymorphisms
RFLP(9) : SNPs within 2kb(690 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR023413 Green fluorescent protein-like
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000033 LDLR class B repeat
InterPro IPR016317 Pro-epidermal growth factor
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000006928 pro-epidermal growth factor
Graphical View of Protein Domain Structure
References
(Earliest) J:70074 Nexo E, et al., Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development. Proc Natl Acad Sci U S A. 1980 May;77(5):2782-5
(Latest) J:201657 Okano-Uchida T, et al., Cerebellar neural stem cells differentiate into two distinct types of astrocytes in response to CNTF and BMP2. Neurosci Lett. 2013 Sep 27;552:15-20
All references(204)
Other
accession IDs
MGD-MRK-9315, MGI:2139798

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory