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Egf Gene Detail
Summary
  • Symbol
    Egf
  • Name
    epidermal growth factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:95290
    NCBI Gene: 13645
  • Gene Overview
    MyGene.info: EGF
Location & Maps
more
  • Sequence Map
    Chr3:129677565-129755316 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      77752 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 58.50 cM
  • Mapping Data
    40 experiments
Homology
more
  • Human Ortholog
    EGF, epidermal growth factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EGF, epidermal growth factor
    Orthology source: HomoloGene
  • Synonyms
    HOMG4, URG
  • Links
    NCBI Gene ID: 1950
    neXtProt AC: NX_P01133

  • Chr Location
    4q25; chr4:109912883-110012962 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human EGF associations

Human Disease Mouse Models
       Hypomagnesemia 4, Renal; HOMG4   OMIM: 611718
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    19 phenotypes from multigenic genotypes
    13 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Egf
  • Incidental Mutations
Null mutants have normal phenotype. Females triply null, for this locus and the amphiregulin and transforming growth factor alpha genes, are unable to nurse due to impaired mammary gland development and show mild integument and digestive system anomalies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054128 VEGA Gene Model | MGI Sequence Detail 77752 C57BL/6J ±  kb
transcript OTTMUST00000134475 VEGA | MGI Sequence Detail 4761 Not Applicable  
polypeptide OTTMUSP00000071300 VEGA | MGI Sequence Detail 1217 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    686 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 156
    Genomic 3
    cDNA 142
    Primer pair 10
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-9315, MGI:2139798
References
more
  • Summaries
    All 207
    Developmental Gene Expression 39
    Gene Ontology 27
    Phenotypes 13
  • Earliest
    J:70074 Nexo E, et al., Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development. Proc Natl Acad Sci U S A. 1980 May;77(5):2782-5
  • Latest
    J:221164 Di Giovanni V, et al., Fibroblast growth factor receptor-Frs2alpha signaling is critical for nephron progenitors. Dev Biol. 2015 Apr 1;400(1):82-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory