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Edn2 Gene Detail
Summary
  • Symbol
    Edn2
  • Name
    endothelin 2
  • Synonyms
    vasoactive intestinal contractor peptide, VIC
  • Feature Type
    protein coding gene
  • IDs
    MGI:95284
    NCBI Gene: 13615
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:120018403-120024557 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 55.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95284
 protein coding gene Chr4:120018403-120024557 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028706
 protein coding gene Chr4:121392638-121399901 (+)
A/J MGP_AJ_G0028666
 protein coding gene Chr4:116620706-116626860 (+)
AKR/J MGP_AKRJ_G0028619
 protein coding gene Chr4:119164417-119170571 (+)
BALB/cJ MGP_BALBcJ_G0028689
 protein coding gene Chr4:117241132-117247586 (+)
C3H/HeJ MGP_C3HHeJ_G0028404
 protein coding gene Chr4:120717366-120723528 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029130
 protein coding gene Chr4:125978555-125984757 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026407
 protein coding gene Chr4:110710725-110716893 (+)
CAST/EiJ MGP_CASTEiJ_G0027835
 protein coding gene Chr4:118059290-118065418 (+)
CBA/J MGP_CBAJ_G0028371
 protein coding gene Chr4:129390373-129396496 (+)
DBA/2J MGP_DBA2J_G0028518
 protein coding gene Chr4:117211940-117218088 (+)
FVB/NJ MGP_FVBNJ_G0028484
 protein coding gene Chr4:115724721-115732686 (+)
LP/J MGP_LPJ_G0028618
 protein coding gene Chr4:121530991-121537161 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028512
 protein coding gene Chr4:134265641-134271778 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029167
 protein coding gene Chr4:120236580-120242733 (+)
PWK/PhJ MGP_PWKPhJ_G0027558
 protein coding gene Chr4:114139717-114145950 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027384
 protein coding gene Chr4:116666124-116672304 (+)
WSB/EiJ MGP_WSBEiJ_G0027915
 protein coding gene Chr4:120243966-120250142 (+)



Homology
more
  • Human Ortholog
    EDN2, endothelin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EDN2, endothelin 2
  • Synonyms
    ET2, ET-2, PPET2
  • Links
    NCBI Gene ID: 1907
    neXtProt AC: NX_P20800
    UniProt: P20800

  • Chr Location
    1p34.2; chr1:41478775-41484683 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EDN2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 4 alleles in 7 genetic backgrounds
    22 phenotypes from multigenic genotypes
    13 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit growth retardation, hypothermia, hypoxemic hypoxia, hypercapnia, emphysema and premature death. Females exhibit impaired ovulation and a lack of corpora lutea formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    918
  • Tissues
    75
  • cDNA Data
    10
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13615 NCBI Gene Model | MGI Sequence Detail 6155 C57BL/6J ±  kb
    transcript NM_007902 RefSeq | MGI Sequence Detail 1514 Not Specified  
    polypeptide P22389 UniProt | EBI | MGI Sequence Detail 175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 10
      Primer pair 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9299
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 15
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:17960 Saida K, et al., A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity. J Biol Chem. 1989 Sep 5;264(25):14613-6
    • Latest
      J:286621 Iwagawa T, et al., Cd9 Protects Photoreceptors from Injury and Potentiates Edn2 Expression. Invest Ophthalmol Vis Sci. 2020 Mar 9;61(3):7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory