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Dsg1a
Gene Detail
 Symbol
Name
ID
Dsg1a
desmoglein 1 alpha
MGI:94930
Synonyms Dsg1
Feature Type protein coding gene
Genetic Map
Chromosome 18
11.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr18:20310811-20343350 bp, + strand
From VEGA annotation of GRCm38

  32540 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1463  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Dsg1a

Human
homologs
Human Homolog DSG1, desmoglein 1
NCBI Gene ID 1828
neXtProt AC  NX_Q02413
Human Synonyms  CDHF4, DG1, DSG, EPKHE, EPKHIA, PPKS1, SPPK1
Human Chr (Location)  18q12.1; chr18:31318089-31357431 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human DSG1
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell adhesion, homophilic cell adhesion
Component apical plasma membrane, cell-cell junction, ...
Function calcium ion binding, gamma-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (17)    Tissues (15)    Images (3)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
Immunohistochemistry 2
Western blot 2
RT-PCR 13
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016312 (Evidence)
Ensembl Gene ModelENSMUSG00000069441 (Evidence)
Entrez Gene13510 (Evidence)
UniGene37953
DoTSDT.101736673
Consensus CDS ProjectCCDS50231.1
International Mouse Knockout Project StatusDsg1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016312 VEGA Gene Model | MGI Sequence Detail 32540 C57BL/6J ±  kb
transcript OTTMUST00000039194 VEGA | MGI Sequence Detail 5686 Not Applicable 
polypeptide OTTMUSP00000017506 VEGA | MGI Sequence Detail 1057 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(127 from dbSNP Build 137)    SNPs within 2kb including multiple locations(137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR027397 Catenin binding domain
InterPro IPR009123 Desmoglein
InterPro IPR009122 Desmosomal cadherin
Protein Ontology PR:000006848 desmoglein-1-alpha
References (Earliest) J:4712 Buxton RS, et al., Nomenclature of the desmosomal cadherins. J Cell Biol. 1993 May;121(3):481-3
(Latest) J:191121 Ferone G, et al., p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome. Hum Mol Genet. 2013 Feb 1;22(3):531-43
All references(62)
Other
accession IDs
MGD-MRK-8905, MGI:2147383

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory